A Multi-Modal Remote Monitoring Platform for Frontotemporal Lobar Degeneration Syndromes
额颞叶变性综合征的多模式远程监测平台
基本信息
- 批准号:10597923
- 负责人:
- 金额:$ 125万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-30 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:Activities of Daily LivingAffectAlgorithmsAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAmyotrophic Lateral SclerosisAnxietyArchitectureAttitudeAwardBasal GangliaBiological MarkersCaringCessation of lifeClinicClinical ResearchClinical TrialsCognitionCognitiveCollaborationsCollectionCustomDataData CollectionData SecurityDementiaDementia with Lewy BodiesDepositionDevelopmentDiseaseDisease OutcomeDisease ProgressionDysarthriaFDA approvedFeedbackFrontotemporal DementiaFrontotemporal Lobar DegenerationsFundingFutureGaitGeneral HospitalsGovernmentGrantHealth TechnologyHomeIndividualInterviewLegal patentMassachusettsMeasurementMeasuresMedical RecordsModelingMonitorMotorMovementMulticenter StudiesMultiple System AtrophyMyotonic DystrophyNeckNeurodegenerative DisordersOnline SystemsOutcomeOutcome MeasureParkinson DiseaseParticipantPathologicPatient Outcomes AssessmentsPatientsPerceptionPersonsPharmacologic SubstancePhasePhysical activityPhysical assessmentPilot ProjectsPostureProgressive Supranuclear PalsyProtocols documentationPsychomotor PerformanceQuality of lifeRecommendationResearchResearch DesignRiskSeverity of illnessSmall Business Innovation Research GrantSmall Business Technology Transfer ResearchSpeechStrokeSymptomsSyndromeSystemSystems DevelopmentTabletsTauopathiesTechnologyTestingTherapeutic EffectTherapeutic InterventionTimeLineTrustUnited States National Institutes of HealthUniversitiesVendorbasecognitive functioncognitive testingcomputerizedcorticobasal syndromedata accessdigitaldisabilityeffective therapyequilibration disorderfall riskfallsimprovedinstrumentmHealthmachine learning algorithmmotor symptommultimodalitynervous system disordernovel therapeuticsprimary outcomerecruitremote monitoringsensortau Proteinstau mutationtoolvirtual visitwearable sensor technology
项目摘要
Project Summary/Abstract
Frontotemporal lobar degeneration (FTLD) syndromes span the spectrum of neurodegenerative disorders
affecting movement and cognitive function and are pathologically related to Alzheimer's disease. In this project,
we will develop a robust multi-modal platform for remote monitoring of motor symptoms, speech and cognitive
function in FTLD syndromes using wearable sensors and digitized tests. We will validate this solution in
Progressive Supranuclear Palsy (PSP) by collecting longitudinal data from 60 PSP patients over a period of 12
months. PSP is a severe and rapidly progressive FTLD syndrome that lacks effective treatment and leads to
rapid onset of dementia, disability and death. The rapid progression of PSP will allow us to validate the solution
within the timeline of this Direct Phase II SBIR project and facilitate future studies in FTLD syndromes.
In this Direct Phase II project, we will recruit 60 participants with PSP from 2 leading CurePSP Centers of Care.
These participants will be monitored for 12 months. The sensor data will be collected using PAMSys, a wearable
sensor developed by the support from a NIH STTR grant award. PAMSys is patented (U.S. Patents # 8,206,325,
9,005,141, and 9,901,209), validated and commercialized by BioSensics. The digitized tests will be collected
using BioDigit Home, a unified solution for the collection of digital biomarkers that is currently being used in
several NIH-funded studies and pharma-sponsored clinical trials in neurological disorders. BioSensics has
already customized its BioDigit Home solution to monitor motor, speech and cognitive functions in PSP, and has
carried out a pilot study with 7 PSP patients, who were monitored for up to 3 months using the developed system.
We will collect data from 60 PSP patients in this aim to develop a set of algorithms for monitoring motor, speech
and cognitive function that will enable objective assessment of PSP disease severity and progression, thereby
creating a multi-modal remote monitoring solution for PSP. These tools will accelerate clinical trials that are
focused on the development of novel therapeutics for tauopathies (i.e., FTD, PSP CBS) and can be readily
adapted to many neurodegenerative diseases, including Parkinson's disease, multiple system atrophy,
amyotrophic lateral sclerosis, myotonic dystrophy and stroke.
BioSensics is a 2020 Tibbetts Award winner with a proven track record of rapidly transitioning applied
governmental research funding into real commercial results. The initial market for our technology is
pharmaceutical clinical trials, where BioSensics is a vendor of record of medical-grade wearable sensors and
digital clinical trial technologies for multiple pharmaceutical companies. The current project will significantly
broaden BioSensics' offerings to pharmaceutical companies, specifically by providing a solution for digital
assessments of speech, motor and cognition function, which are relevant to many diseases. This commercial
potential is fully aligned with the latest recommendations from the FDA, NSF and NIH to digitize clinical trials.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Alexander Y. Pantelyat其他文献
The effects of personally preferred music on mood and behaviour in individuals with dementia: An exploratory pilot study
个人喜欢的音乐对痴呆症患者情绪和行为的影响:一项探索性试点研究
- DOI:
10.56883/aijmt.2024.78 - 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Stephanie Cairo;K. Kang;Patricia Izbicki;Molly Isinghood;Tabassum Majid;Alexander Y. Pantelyat - 通讯作者:
Alexander Y. Pantelyat
Impact of Magnetic Resonance Imaging Markers on the Diagnostic Performance of the International Parkinson and Movement Disorder Society Multiple System Atrophy Criteria.
磁共振成像标记对国际帕金森和运动障碍协会多系统萎缩标准诊断性能的影响。
- DOI:
10.1002/mds.29879 - 发表时间:
2024 - 期刊:
- 影响因子:8.6
- 作者:
Ida Jensen;Johanne Heine;Viktoria C Ruf;Y. Compta;Laura Molina Porcel;C. Troakes;Albert Vamanu;Sophia Downes;David Irwin;Jesse Cohen;Edward B Lee;Christer Nilsson;Elisabet Englund;Mojtaba Nemati;S. Katzdobler;J. Levin;Alexander Y. Pantelyat;J. Seemiller;Stephen L Berger;J. V. van Swieten;E. Dopper;Annemieke Rozenmuller;Gabor G Kovacs;Nathaniel Bendahan;Anthony E. Lang;Jochen Herms;Günter U. Höglinger;Franziska Hopfner - 通讯作者:
Franziska Hopfner
Alexander Y. Pantelyat的其他文献
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{{ truncateString('Alexander Y. Pantelyat', 18)}}的其他基金
A Multi-Modal Remote Monitoring Platform for Frontotemporal Lobar Degeneration Syndromes
额颞叶变性综合征的多模式远程监测平台
- 批准号:
10707379 - 财政年份:2022
- 资助金额:
$ 125万 - 项目类别:
Multi-modal magnetic resonance imaging in progressive supranuclear palsy (PSP)
进行性核上性麻痹 (PSP) 的多模态磁共振成像
- 批准号:
10408127 - 财政年份:2018
- 资助金额:
$ 125万 - 项目类别:
Multi-modal magnetic resonance imaging in progressive supranuclear palsy (PSP)
进行性核上性麻痹 (PSP) 的多模态磁共振成像
- 批准号:
10183124 - 财政年份:2018
- 资助金额:
$ 125万 - 项目类别:
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