Administrative Core

行政核心

• 批准号: 10409741
• 负责人: Victor Henderson
• 金额: $ 66.99万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10409741
• 关键词: Adopted; Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Alzheimer’s disease biomarker; Biological; Brain; Caregivers; Caring; Clinical; Cognition; Collaborations; Communities; Data; Dementia; Dementia with Lewy Bodies; Development; Diagnosis; Early Diagnosis; Ensure; Evaluation; Genetic; Goals; Guidelines; Health Professional; Hispanic; Impaired cognition; Individual; Infrastructure; Institutional Review Boards; Interdisciplinary Study; Latino Population; Leadership; Lewy Bodies; Lewy body pathology; Lewy neurites; Link; Microscopic; Mission; Monitor; National Institute on Aging; Nerve Degeneration; Neurofibrillary Tangles; Parkinson Disease; Parkinson' s Dementia; Participant; Pathologic; Pathology; Persons; Phenotype; Policies; Procedures; Process; Reporting; Research; Research Personnel; Research Training; Resource Sharing; Resources; Risk; Specimen; Structure; Time; United States National Institutes of Health; Universities; Update; age related; aging brain; alpha synuclein; data exchange; data storage site; disparity reduction; ethnic minority; high risk; improved; innovation; mild cognitive impairment; next generation; pre-clinical; prevent; racial minority population; ranpirnase; repository

1. SUMMARY (Administrative Core) The Stanford Alzheimer's Disease Research Center (ADRC) will support goals of the National Alzheimer's Project Act by serving as a shared resource to facilitate and enhance interdisciplinary and multidisciplinary research on Alzheimer's disease and Alzheimer's disease related dementia (AD/ADRD). At the Stanford ADRC, the focus will be on AD and a common ADRD, namely cognitive impairment and dementia linked to Lewy bodies, Lewy neurites, and the abnormal accumulation and propagation of alpha-synuclein (the Lewy body spectrum of neurodegenerative cognitive impairment). The Stanford ADRC has adopted a strategy of deep phenotyping, which draws together multiple levels of biological data on individual participants followed over time and culminating in brain donation. The Administrative Core provides the administrative structure needed to direct, facilitate and support the Stanford ADRC mission. It establishes the overall scientific direction, provides a forum for planning, ensures optimal resource utilization, and assures compliance with institutional and NIH policy requirements. It will accomplish these goals during the next five years through four specific aims: (1) Provide an infrastructure that establishes priorities and goals of the P30 Stanford ADRC: coordinate activities of ADRC cores and committees; ensure compliance with reporting procedures, policies, and guidelines of the NIH, institutional review board, and other relevant bodies; oversee data transfer to the National Alzheimer's Coordinating Center (NACC) and other entities; and oversee the transfer of biological specimens and genetic data to the National Centralized Repository for Alzheimer's Disease (NCRAD), National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS), and other collaborating groups; (2) Stimulate innovative research on AD/ADRD by existing and new investigators, including the solicitation, evaluation, selection, and monitoring of development projects supported by the Center; (3) Provide leadership opportunities for the next generation of ADRC leaders; and (4) Promote research, training, and educational collaborations with other ADRCs, universities, health professionals, caregiver organizations, and the wider scientific and lay communities.

1.摘要(行政核心) 斯坦福阿尔茨海默病研究中心(ADRC)将支持国家阿尔茨海默氏症协会的目标 项目行动，作为促进和加强跨学科和多学科的共享资源 阿尔茨海默病和阿尔茨海默病相关痴呆(AD/ADRD)研究。在斯坦福大学 ADRC，重点将放在AD和一种常见的ADRD上，即认知障碍和痴呆症有关 路易小体、路易神经突起与α-突触核蛋白的异常积聚和增殖 神经退行性认知障碍的身体谱)。斯坦福ADRC采取了一项战略， 随后是深入的表型分析，它收集了关于个体参与者的多个水平的生物数据 随着时间的推移，最终达到了大脑捐赠的目的。管理核心提供了管理结构 需要指导、协助和支持斯坦福ADRC的使命。它确立了全面科学的 方向，为规划提供论坛，确保最佳资源利用，并确保遵守 机构和国家卫生研究院的政策要求。它将在未来五年到四年内实现这些目标 具体目标：(1)提供基础设施，确立P30斯坦福ADRC的优先事项和目标： 协调ADRC核心和委员会的活动；确保遵守报告程序、政策、 和NIH、机构审查委员会和其他相关机构的指导方针；监督数据传输到 国家阿尔茨海默氏症协调中心(NACC)和其他实体；并监督生物 国家阿尔茨海默病中央资料库(NCRAD)的样本和基因数据 阿尔茨海默病老化遗传学数据存储网站(NIAGADS)和其他合作伙伴 小组；(2)鼓励现有和新的调查员对AD/ADRD进行创新研究，包括 中心支持的发展项目的征集、评估、选择和监测；(3)提供 (4)促进研究、培训和 与其他ADRC、大学、卫生专业人员、护理人员组织和 更广泛的科学界和非科学界。