Administrative Core

行政核心

• 批准号: 10647860
• 负责人: Victor Henderson
• 金额: $ 84.95万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10647860
• 关键词: Adopted; Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Alzheimer’s disease biomarker; Biological; Brain; Caregivers; Caring; Clinical; Cognition; Collaborations; Communities; Data; Dementia; Dementia with Lewy Bodies; Development; Diagnosis; Early Diagnosis; Education; Ensure; Evaluation; Genetic; Goals; Guidelines; Health Professional; Hispanic; Impaired cognition; Individual; Infrastructure; Institution; Institutional Review Boards; Interdisciplinary Study; Latino Population; Leadership; Lewy Bodies; Lewy body pathology; Lewy neurites; Link; Microscopic; Mission; Monitor; National Institute on Aging; Nerve Degeneration; Neurofibrillary Tangles; Parkinson Disease; Parkinson' s Dementia; Participant; Pathologic; Pathology; Persons; Phenotype; Policies; Procedures; Process; Reporting; Research; Research Personnel; Resource Sharing; Resources; Risk; Specimen; Structure; Time; Training; United States National Institutes of Health; Universities; Update; age related; aging brain; alpha synuclein; data exchange; data storage site; disparity reduction; ethnic minority population; high risk; improved; innovation; mild cognitive impairment; next generation; pre-clinical; prevent; racial minority population; repository

1. SUMMARY (Administrative Core) The Stanford Alzheimer's Disease Research Center (ADRC) will support goals of the National Alzheimer's Project Act by serving as a shared resource to facilitate and enhance interdisciplinary and multidisciplinary research on Alzheimer's disease and Alzheimer's disease related dementia (AD/ADRD). At the Stanford ADRC, the focus will be on AD and a common ADRD, namely cognitive impairment and dementia linked to Lewy bodies, Lewy neurites, and the abnormal accumulation and propagation of alpha-synuclein (the Lewy body spectrum of neurodegenerative cognitive impairment). The Stanford ADRC has adopted a strategy of deep phenotyping, which draws together multiple levels of biological data on individual participants followed over time and culminating in brain donation. The Administrative Core provides the administrative structure needed to direct, facilitate and support the Stanford ADRC mission. It establishes the overall scientific direction, provides a forum for planning, ensures optimal resource utilization, and assures compliance with institutional and NIH policy requirements. It will accomplish these goals during the next five years through four specific aims: (1) Provide an infrastructure that establishes priorities and goals of the P30 Stanford ADRC: coordinate activities of ADRC cores and committees; ensure compliance with reporting procedures, policies, and guidelines of the NIH, institutional review board, and other relevant bodies; oversee data transfer to the National Alzheimer's Coordinating Center (NACC) and other entities; and oversee the transfer of biological specimens and genetic data to the National Centralized Repository for Alzheimer's Disease (NCRAD), National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS), and other collaborating groups; (2) Stimulate innovative research on AD/ADRD by existing and new investigators, including the solicitation, evaluation, selection, and monitoring of development projects supported by the Center; (3) Provide leadership opportunities for the next generation of ADRC leaders; and (4) Promote research, training, and educational collaborations with other ADRCs, universities, health professionals, caregiver organizations, and the wider scientific and lay communities.

1.摘要（行政核心） 斯坦福大学阿尔茨海默氏症研究中心（ADRC）将支持国家阿尔茨海默氏症 作为一种共享资源，促进和加强跨学科和多学科的项目法 阿尔茨海默病和阿尔茨海默病相关痴呆（AD/ADRD）的研究。在斯坦福大学 ADRC，重点将放在AD和一个共同的ADRD，即认知障碍和痴呆症相关的 路易体、路易神经突和α-突触核蛋白的异常积累和增殖（路易体） 神经退行性认知障碍的身体谱）。斯坦福大学ADRC采取了一项战略， 深入的表型分析，它汇集了个体参与者的多层次生物学数据， 最终捐献出大脑行政核心提供行政结构 需要指导，促进和支持斯坦福大学ADRC使命。它建立了全面的科学 方向，提供规划论坛，确保最佳资源利用，并确保遵守 机构和NIH政策要求。它将在未来五年内通过四年实现这些目标 具体目标：（1）提供基础设施，确定P30斯坦福大学ADRC的优先事项和目标： 协调ADRC核心和委员会的活动;确保遵守报告程序，政策， 以及NIH、机构审查委员会和其他相关机构的指南;监督数据转移到 国家阿尔茨海默氏症协调中心（NACC）和其他实体;并监督生物技术的转移。 样本和遗传数据，以国家阿尔茨海默病中央储存库（NCRAD），国家 老年痴呆症数据存储网站衰老遗传学研究所（NIAGADS）和其他合作机构 （2）激励现有和新的研究人员对AD/ADRD进行创新研究，包括 （3）对中心支持的发展项目进行征集、评估、选择和监督; 为下一代ADRC领导人提供领导机会;以及（4）促进研究，培训， 与其他ADRC、大学、卫生专业人员、护理人员组织和 更广泛的科学界和非科学界。