Core C: Clinical Core

核心 C：临床核心

• 批准号: 10555692
• 负责人: Victor Henderson
• 金额: $ 16.95万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10555692
• 关键词: Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease risk; Asian; Asian Americans; Asian population; Assessment tool; Biological Markers; Clinical; Clinical dementia rating scale; Cognition; Cognitive; Consensus; Cultural Sensitivity; Data; Data Collection; Dementia; Diagnosis; Diet; Documentation; Elderly; Ensure; Evaluation; Exclusion Criteria; Feedback; Future; Genetic; Goals; Life Experience; Life Style; Linguistics; Medical; Medical History; Neurologic; Neurological observations; Neurologist; Participant; Plasma; Population; Procedures; Process; Protocols documentation; Reporting; Research Project Grants; Risk Factors; Site; Stream; Subgroup; Training; adjudication; balance testing; bilingualism; cohort; dementia risk; design; experience; follow-up; genetic analysis; geriatric depression; improved; innovation; instrument; mild cognitive impairment; non-genetic; phrases; protective factors; quality assurance; recruit; waiver

Clinical Core (Core C) Abstract The overall goals of Clinical Core (Core C) are: 1) to collect data through harmonized clinical procedures and data collection packets for the valid consensus diagnoses of Asian older adults who have AD-dementia or AD-MCI or who are cognitively normal, 2) to develop innovative and culturally and linguistically appropriate assessment tools to assess diverse Asian subgroups, and 3) to provide clinical expertise related to clinical manifestations of AD to help guide the design of ACAD research projects. For this project, we will collect information on lifestyle and medical history and evaluate the neurological findings and cognition of older Asians to help answer key questions about the genetics and non-genetic risk factors for Alzheimer’s disease Asian American and Asian Canadian populations. As this is the first effort of its kind with Asian populations, we will continue to revise our Data Collection Packet (DCP) to elicit the needed information with high cultural sensitivity and using validated instruments where already available. We will also validate adaptations to the instruments that we have made more culture- fair to Asian populations.

临床核心（核心C）摘要 临床核心（核心C）的总体目标是：1）通过协调临床 亚洲老年人有效共识诊断的程序和数据收集包 患有AD-痴呆或AD-MCI或认知正常的成年人，2）发展 创新和文化和语言上适当的评估工具，以评估不同的亚洲 亚组，3）提供与AD临床表现相关的临床专业知识， 指导ACAD研究项目的设计。在这个项目中，我们将收集以下信息： 生活方式和病史，并评估老年亚洲人的神经学发现和认知 帮助回答关于阿尔茨海默氏症的遗传和非遗传风险因素的关键问题 亚裔美国人和亚裔加拿大人。因为这是第一次 对于亚洲人群，我们将继续修订我们的数据收集包（DCP）， 需要高度文化敏感性的信息，并在已经 available.我们还将验证对我们创造的更多文化的工具的改编- 公平对待亚洲人。