Core C: Clinical Core

核心 C：临床核心

基本信息

批准号：
10555692
负责人：
Victor Henderson
金额：
$ 16.95万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10555692
关键词：
Alzheimer&apos s Disease Alzheimer&apos s disease diagnosis Alzheimer&apos s disease risk Asian Asian Americans Asian population Assessment tool Biological Markers Clinical Clinical dementia rating scale Cognition Cognitive Consensus Cultural Sensitivity Data Data Collection Dementia Diagnosis Diet Documentation Elderly Ensure Evaluation Exclusion Criteria Feedback Future Genetic Goals Life Experience Life Style Linguistics Medical Medical History Neurologic Neurological observations Neurologist Participant Plasma Population Procedures Process Protocols documentation Reporting Research Project Grants Risk Factors Site Stream Subgroup Training adjudication balance testing bilingualism cohort dementia risk design experience follow-up genetic analysis geriatric depression improved innovation instrument mild cognitive impairment non-genetic phrases protective factors quality assurance recruit waiver

项目摘要

Clinical Core (Core C) Abstract The overall goals of Clinical Core (Core C) are: 1) to collect data through harmonized clinical procedures and data collection packets for the valid consensus diagnoses of Asian older adults who have AD-dementia or AD-MCI or who are cognitively normal, 2) to develop innovative and culturally and linguistically appropriate assessment tools to assess diverse Asian subgroups, and 3) to provide clinical expertise related to clinical manifestations of AD to help guide the design of ACAD research projects. For this project, we will collect information on lifestyle and medical history and evaluate the neurological findings and cognition of older Asians to help answer key questions about the genetics and non-genetic risk factors for Alzheimer’s disease Asian American and Asian Canadian populations. As this is the first effort of its kind with Asian populations, we will continue to revise our Data Collection Packet (DCP) to elicit the needed information with high cultural sensitivity and using validated instruments where already available. We will also validate adaptations to the instruments that we have made more culture- fair to Asian populations.

临床核心（核心C）摘要临床核心的总体目标（核心C）是：1）通过统一的临床收集数据用于有效共识诊断的程序和数据收集数据包患有addementia或ad-MCI或认知正常的成年人，2）创新，文化和语言上适当的评估工具来评估亚洲潜水亚组和3）提供与AD临床表现相关的临床专业知识以帮助指导ACAD研究项目的设计。对于这个项目，我们将收集有关生活方式和病史并评估了对年龄较大的亚洲人的神经系统发现和认知帮助回答有关阿尔茨海默氏症的遗传学和非遗传危险因素的关键问题疾病亚裔美国人和亚裔加拿大人口。因为这是同类的第一个努力对于亚洲人群，我们将继续修改我们的数据收集数据包（DCP），以引起需要具有很高文化敏感性的需要信息，并使用经过验证的工具已经可用的。我们还将验证适应我们已经提供更多文化的工具 - 对亚洲人口公平。