Core C: Clinical Core

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Clinical Core (Core C) Abstract The overall goals of Clinical Core (Core C) are: 1) to collect data through harmonized clinical procedures and data collection packets for the valid consensus diagnoses of Asian older adults who have AD-dementia or AD-MCI or who are cognitively normal, 2) to develop innovative and culturally and linguistically appropriate assessment tools to assess diverse Asian subgroups, and 3) to provide clinical expertise related to clinical manifestations of AD to help guide the design of ACAD research projects. For this project, we will collect information on lifestyle and medical history and evaluate the neurological findings and cognition of older Asians to help answer key questions about the genetics and non-genetic risk factors for Alzheimer’s disease Asian American and Asian Canadian populations. As this is the first effort of its kind with Asian populations, we will continue to revise our Data Collection Packet (DCP) to elicit the needed information with high cultural sensitivity and using validated instruments where already available. We will also validate adaptations to the instruments that we have made more culture- fair to Asian populations.