Vascular Deformation Mapping (VDM) for Automated, 3D Assessment of Thoracic Aortic Aneurysm

用于胸主动脉瘤自动 3D 评估的血管变形测绘 (VDM)

• 批准号: 10409547
• 负责人: Nicholas Scott Burris
• 金额: $ 44.97万
• 依托单位: IMBIO, LLC
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10409547
• 关键词: 3-Dimensional; Address; Advanced Development; Algorithms; Angiography; Aorta; Biological Markers; Blood Vessels; Caliber; Cardiac; Cardiovascular system; Caring; Chronic; Chronic Obstructive Pulmonary Disease; Clinical; Collaborations; Communication; Computer software; Data; Development; Disease; Disease Progression; Dissection; Early identification; Environment; Evaluation; Future; Goals; Grant; Growth; Guidelines; Hospitals; Image; Image Analysis; Imaging Techniques; Incidence; Length; Life; Manuals; Maps; Measurement; Measures; Methods; Michigan; Modernization; Monitor; Operative Surgical Procedures; Patient-Focused Outcomes; Patients; Performance; Phase; Population; Preparation; Reporting; Reproducibility; Research Personnel; Resolution; Retrospective cohort; Risk; Rupture; Speed; Summary Reports; Surgeon; Techniques; Testing; Thoracic Aortic Aneurysm; Thoracic aorta; Universities; Validation; Validity and Reliability; X-Ray Computed Tomography; algorithm development; automated segmentation; base; care providers; clinically relevant; cohort; commercial application; commercialization; computerized; data acquisition; design; economic impact; experience; health economics; image registration; improved; new technology; novel strategies; portability; product development; radiologist; repaired; response; risk stratification; surveillance imaging; surveillance strategy; tool; two-dimensional

PROJECT SUMMARY Thoracic aortic aneurysm (TAA) is a chronic condition that carries the risk of developing life-threatening complications such as aortic dissection (i.e., delamination of the aortic wall) and rupture (i.e., transmural tearing). The primary management objectives for TAA are to identify aortic dilation early and to surgically replace the aorta before it reaches a size that predicts future complications. It is estimated that 3 million patients in the US alone would meet criteria for aortic imaging surveillance based on current guidelines. Improved imaging surveillance strategies are needed to address the health and economic impacts of TAA. However, the reliability of standard aortic diameter measurements from CT images remains low. In this proposal, we will utilize a recently developed image analysis technique, Vascular Deformation Mapping (VDM), to perform semi-automated, three-dimensional assessment of aortic growth in patients with TAA undergoing imaging surveillance. This novel approach utilizes advanced computerized analysis techniques that make full use of the rich, high-resolution, volumetric data generated by modern CT scanners, to generate a more comprehensive and reliable assessment of aortic growth. VDM has the ability to significantly improve the speed and reliability of TAA growth analysis, facilitate the communication of aortic growth assessment between radiologists, care-providers and patients, and generate new biomarkers of disease progression that can be used to improve patient management decisions, and ultimately patient outcomes. In this grant effort, we propose to achieve the goals of this project through our close partnership between University of Michigan (UM) and Imbio, LLC investigators. Thus the Specific Aims of this Fast-Track proposal will develop a commercial VDM software application, including the product testing and data acquisition necessary for a FDA 510(k) application.

项目总结

项目成果

A Computational Study of Dynamic Obstruction in Type B Aortic Dissection.

B 型主动脉夹层动态阻塞的计算研究。

• DOI: 10.1115/1.4056355
• 发表时间: 2023
• 期刊: Journal of biomechanical engineering
• 作者: Kim,T;vanBakel,PAJ;Nama,N;Burris,N;Patel,HJ;Williams,DM;Figueroa,CA
• 通讯作者: Figueroa,CA

False lumen enhancement characteristics on computed tomography angiography predict risk of aneurysm formation in acute type B aortic dissection.

计算机断层扫描血管造影的假腔增强特征可预测急性 B 型主动脉夹层动脉瘤形成的风险。

• DOI: 10.1093/icvts/ivab095
• 发表时间: 2021
• 期刊: Interactive cardiovascular and thoracic surgery
• 作者: Roseland,MollyE;Ahmed,Yunus;vanHerwaarden,JoostA;Moll,FransL;Yang,Bo;Patel,HimanshuJ;Burris,NicholasS
• 通讯作者: Burris,NicholasS

Imaging surveillance after open aortic repair: a feasibility study of three-dimensional growth mapping.

开放式主动脉修复术后的影像监测：三维生长图的可行性研究。

• DOI: 10.1093/ejcts/ezab142
• 发表时间: 2021
• 期刊: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
• 作者: Ahmed,Yunus;Nama,Nitesh;Houben,IgnasB;vanHerwaarden,JoostA;Moll,FransL;Williams,DavidM;Figueroa,CAlberto;Patel,HimanshuJ;Burris,NicholasS
• 通讯作者: Burris,NicholasS

Vascular Deformation Mapping of Abdominal Aortic Aneurysm.

• DOI: 10.3390/tomography7020017
• 发表时间: 2021-05-13
• 期刊: Tomography (Ann Arbor, Mich.)
• 作者: Braet DJ;Eliason J;Ahmed Y;van Bakel PAJ;Zhong J;Bian Z;Figueroa CA;Burris NS
• 通讯作者: Burris NS