Neurobiology of CNS Injury and Repair

中枢神经系统损伤与修复的神经生物学

• 批准号: 10408900
• 负责人: Warren Joseph Alilain
• 金额: $ 20.86万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10408900
• 关键词: Neurobiology; central nervous system injury; injury and repair

Project Summary This is a renewal application requesting continued funding for a Neurobiology of CNS Injury and Repair T32 Training Program to support 4 predoctoral fellows per year for a 2-year training period, working toward their PhD degrees in the fields of traumatic brain injury (TBI), spinal cord injury (SCI), or stroke. The overall goal continues to be to prepare highly motivated graduate students for careers in neurotrauma research-related fields by providing broad-based training in the pathophysiology of TBI, SCI, and stroke and the identification of potential disease-modifying molecular targets that can drive the discovery of pharmacological or gene-based therapeutic strategies. An Executive Committee will select trainees from a pool of qualified applicants, generally in their third year of PhD training. Trainees will receive intensive hands-on research mentoring, with an emphasis on understanding and applying quantitative assessment tools in laboratories of Training Faculty appointed in the Depts. of Neuroscience, Physiology, Molecular and Cellular Biochemistry, and Pharmaceutical Sciences who regularly interact and collaborate through their affiliation with the University of Kentucky's (UK) Spinal Cord & Brain Injury Research Center and Center for Advanced Translational Stroke Science (CATSS). In addition to coursework, trainees will engage in journal clubs, responsible conduct of research training, Center and Departmental seminar series, and a customized set of program-wide meetings in Professional Skills, and Quantitative Literacy-Experimental Design and Statistics (PSQL-EDS). The monthly PSQL-EDS will facilitate active learning of concepts such as quantitative literacy, statistical analysis, and scientific rigor, as well as scientific writing and professional development. Of the students appointed to the T32 Program in the previous 9 years, 13 have completed their PhDs, 2 will complete their PhDs in year 10, and 6 will continue their PhD training. All those that completed their PhDs continued into science-related positions. Several are continuing their education (3 postdocs, 1 resident), one is an AAAS science policy fellow at the NIH, and the majority are pursuing careers in academia (3 Assistant Professors, 1 instructor, 1 researcher) and biomedical industry (2). The PhD completion and career placement success of the T32 Program is further highlighted by an outstanding record of recruiting and retaining diverse trainees: a large proportion of appointees are of underrepresented race or ethnicity, have a disability, or come from disadvantaged backgrounds. The program's success and continued evolution will be guided by two groups: an Executive Committee comprised of the Program Directors, Training Faculty, and senior UK faculty who bring expertise in administration, mentoring, and inclusion research initiatives, and an External Advisory Board of national leaders in TBI, SCI, and stroke research. Through the pairing of comprehensive, research-intensive training with didactic and interactive educational/career development activities delivered from diverse perspectives, this T32 Program is uniquely positioned to fill a growing need for rigorously trained scientists who desire careers in neurotrauma.

项目摘要 这是一份更新申请，要求继续资助CNS损伤和修复T32的神经生物学 培训计划每年支持4名博士前研究员，为期2年的培训期， 创伤性脑损伤（TBI），脊髓损伤（SCI）或中风领域的博士学位。总目标 继续是准备高度积极的研究生在神经创伤研究相关的职业生涯 通过提供TBI、SCI和中风病理生理学方面的广泛培训， 潜在的疾病修饰分子靶点，可以推动药理学或基因为基础的发现， 治疗策略执行委员会将从合格的申请人中挑选受训人员， 一般是在博士生的第三年。学员将接受密集的实践研究指导， 强调在培训学院的实验室中理解和应用定量评估工具 在各部门任命。神经科学，生理学，分子和细胞生物化学，和制药 通过与肯塔基州大学（英国）的联系定期互动和合作的科学家 脊髓和脑损伤研究中心和高级转化中风科学中心（CATSS）。 除了课程，学员将参加期刊俱乐部，负责进行研究培训， 中心和部门研讨会系列，以及一套定制的全项目范围的专业会议 技能和定量识字实验设计和统计（PSQL-EDS）。每月的PSQL-EDS将 促进积极学习概念，如定量识字，统计分析和科学严谨性， 以及科学写作和专业发展。在被任命为T32计划的学生中， 在过去的9年中，13人完成了博士学位，2人将在第10年完成博士学位，6人将继续他们的博士学位。 博士培训。所有完成博士学位的人都继续从事与科学有关的工作。几个是 继续他们的教育（3博士后，1居民），一个是美国国立卫生研究院的AAAS科学政策研究员， 大多数人在学术界（3名助理教授，1名讲师，1名研究员）和生物医学 工业（2）。T32计划的博士学位完成和职业安置成功进一步突出了 在招聘和留住不同的受训人员方面有着出色的记录：大部分被任命者都是 代表性不足的种族或民族，有残疾，或来自弱势背景。的 该计划的成功和持续发展将由两个小组指导：执行委员会，由 项目主任，培训学院，和高级英国教师谁带来的管理专业知识， 指导和包容性研究倡议，以及TBI，SCI， 和中风研究通过将全面的研究密集型培训与教学和 从不同的角度提供互动教育/职业发展活动，这个T32计划是 独特的定位，以满足日益增长的需要，严格训练的科学家谁渴望在神经创伤的职业生涯。