East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional Consortium

东非国际流行病学数据库评估艾滋病 (IeDEA) 区域联盟

• 批准号: 10408822
• 负责人: AGGREY SEMWENDERO SEMEERE
• 金额: $ 360.77万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-05 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10408822
• 关键词: 2019-nCoV; AIDS related cancer; AIDS/HIV problem; Achievement; Acquired Immunodeficiency Syndrome; Address; Adolescent and Young Adult; Affect; Africa; Behavioral; COVID-19; COVID-19 pandemic; Caring; Cervical; Clinic; Clinical; Communities; Country; Data; Data Sources; Databases; Dermatology; Development; Diagnosis; Environment; Epidemiology; Evolution; Fibrinogen; Funding; Gender; Genetic; Geography; Goals; Government Programs; Grant; HIV; Health; Healthcare; Home; Image; Infant; International; Joints; Kaposi Sarcoma; Kenya; Knowledge; Liver diseases; Longevity; Lung; Machine Learning; Malignant neoplasm of cervix uteri; Measures; Mental Depression; Mental Health; Methodology; Methods; Movement; Newborn Infant; Operations Research; Outcome; Patient-Focused Outcomes; Patients; Persons; Policies; Pregnancy; Public Health; Research; Resource-limited setting; Risk Factors; Sampling; Sentinel; Statistical Methods; Structure; Tanzania; Technology; Telemedicine; Treatment outcome; Tuberculosis; Uganda; United Nations; Viral; age group; antiretroviral therapy; base; cancer complication; cancer diagnosis; cardiovascular risk factor; care outcomes; co-infection; cohort; comorbidity; contextual factors; deep learning; eHealth; experience; implementation evaluation; implementation research; insight; new technology; novel; post-COVID-19; programs; scale up; substance use; syndemic; telehealth; tool; treatment guidelines; treatment program; treatment strategy

Project Summary/Abstract: Our primary goal continues to be the provision of answers to questions that clinicians, governments, programs and international organizations consider central to the evolution and sustainability of their long term HIV care and treatment strategies for achieving the UNAIDS 2030 targets of 95-95-95 in the midst of the SARS-CoV-2 pandemic and changes in public health funding priorities. Our central hypothesis is that retention in the HIV care cascade and treatment outcomes are influenced by patient-level demographic, clinical, developmental, and behavioral factors, as well as, factors within the ambient health care and broader contextual environment. We will leverage our strengths, including robust working relationships with HIV treatment programs, a substantial harmonized regional database, plus broad experience in sampling-based methodologies and novel analytical approaches. Over the course of this research we will: SA-1: Describe movement through the HIV care cascade with a focus on identifying broader and health care environment contextual factors that influence optimal retention in care and viral suppression, in the face of global disruption due to the COVID-19 pandemic and changes in donor funding priorities. The Post COVID-19 Double-Sampling Cohort (Post COVID) will address the impact of broader contextual factors (COVID-19) while the Telehealth and Structural Adaptations project will address the impact of health care structure. SA-2: Examine the impact of developmental stage and behavioral factors on retention in the cascade and subsequent outcomes. The multiregional Adolescent and Young Adult Network of IeDEA (AYANI) and regional Measuring Adverse Pregnancy and Newborn Congenital Outcomes (MANGO) cohorts will assess the impact of developmental stage on the cascade, while the Syndemics cohort will address the impact of mental health on the cascade.SA- 3: Examine the immediate and long-term outcomes of people diagnosed with Tuberculosis (TB) with a focus on identifying and addressing factors associated with patient outcomes. The multiregional TB Sentinel Research Network (TB-SRN) will focus on understanding TB outcomes and long-term pulmonary complications including associated factors. SA-4: Explore the use of new technologies, including eHealth and machine (deep) learning to diagnose and manage HIV-associated cancers with a focus on Kaposi’s Sarcoma (KS) and Cervical Cancer. The KS Project will assess implementation of a Dermatology Telehealth Program and the Cervical Cancer Project will assess the implementation of cervical image capture with machine learning for cancer diagnoses and management. SA-5: Examine the epidemiology of NCD comorbidities and ART complications with a focus on the oldest and youngest-age groups affected by HIV. The multi-regional Sentinel Research Network (SRN) will address non-communicable diseases in people living with HIV (PLHIV) > 40 years and the regional MANGO Cohort will address complications of ART/HIV exposure on HIV-Exposed Infants.

项目摘要/摘要： 我们的主要目标继续是提供临床医生，政府， 计划和国际组织认为长期的发展和可持续性核心 HIV护理和治疗策略用于实现UNAIDS 2030目标的95-95-95目标 SARS-COV-2大流行和公共卫生资金重点的变化。我们的中心假设是 艾滋病毒护理级联和治疗结果的保留受患者级人口的影响， 临床，发展和行为因素以及环境医疗保健中的因素，更广泛 上下文环境。我们将利用自己的优势，包括与艾滋病毒的牢固的工作关系 治疗计划，一个实质性的区域数据库，以及基于抽样的广泛经验 方法和新颖的分析方法。在这项研究的过程中，我们将：SA-1：描述 通过艾滋病毒护理级联运动，重点是识别更广泛的医疗保健环境 面对全球破坏，影响护理和病毒抑制最佳保留的上下文因素 由于19号大流行和捐助资金优先级的变化。 COVID-19邮政双采样 队列（COVID后）将解决更广泛的情境因素的影响（Covid-19），而远程医疗 结构适应项目将解决卫生保健结构的影响。 SA-2：检查影响 发展阶段和行为因素在级联和随后的结果中的保留率。这 IEDEA（Ayani）的多区青少年和年轻成人网络和区域测量不利 怀孕和新出生的先天性结果（芒果）队列将评估发育的影响 级联的阶段，而Syndemics队列将解决心理健康对Cascade的影响。 3：检查患有结核病（TB）的人的直接和长期结局 专注于识别和解决与患者预后相关的因素。多区域结核前哨 研究网络（TB-SRN）将专注于了解结核病结果和长期肺 并发症，包括相关因素。 SA-4：探索新技术的使用，包括eHealth 和机器（深）学习诊断和管理与HIV相关的癌症，重点是Kaposi 肉瘤（KS）和宫颈癌。 KS项目将评估皮肤病学远程医疗的实施 程序和宫颈癌项目将评估宫颈图像捕获的实施 用于癌症诊断和管理的机器学习。 SA-5：检查NCD的流行病学 合并症和艺术并发症，重点是受艾滋病毒影响的最古老和最年轻的群体。 多区域哨兵研究网络（SRN）将解决生活中的非通信疾病 艾滋病毒（PLHIV）> 40年，区域芒果队列将解决艺术/艾滋病毒的并发症 关于艾滋病毒暴露的婴儿。