East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional Consortium

东非国际流行病学数据库评估艾滋病 (IeDEA) 区域联盟

• 批准号: 10239930
• 负责人: AGGREY SEMWENDERO SEMEERE
• 金额: $ 330万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-05 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10239930
• 关键词: 2019-nCoV; AIDS related cancer; AIDS/HIV problem; Achievement; Acquired Immunodeficiency Syndrome; Address; Adolescent and Young Adult; Affect; Africa; Behavioral; COVID-19; COVID-19 pandemic; Caring; Cervical; Clinic; Clinical; Communities; Country; Data; Data Sources; Databases; Dermatology; Development; Diagnosis; Environment; Epidemiology; Evolution; Fibrinogen; Funding; Gender; Genetic; Geography; Goals; Government Programs; Grant; HIV; Health; Healthcare; Home; Image; Infant; International; Joints; Kaposi Sarcoma; Kenya; Knowledge; Liver diseases; Longevity; Lung; Machine Learning; Malignant neoplasm of cervix uteri; Measures; Mental Depression; Mental Health; Methodology; Methods; Movement; Newborn Infant; Operations Research; Outcome; Patient-Focused Outcomes; Patients; Persons; Policies; Pregnancy; Public Health; Research; Resources; Risk Factors; Sampling; Sentinel; Statistical Methods; Structure; Tanzania; Technology; Telemedicine; Treatment outcome; Tuberculosis; Uganda; United Nations; Viral; age group; antiretroviral therapy; base; cancer complication; cancer diagnosis; cardiovascular risk factor; care outcomes; co-infection; cohort; comorbidity; contextual factors; coronavirus disease; deep learning; eHealth; experience; implementation research; insight; new technology; novel; programs; scale up; substance use; telehealth; tool; treatment guidelines; treatment program; treatment strategy

Project Summary/Abstract: Our primary goal continues to be the provision of answers to questions that clinicians, governments, programs and international organizations consider central to the evolution and sustainability of their long term HIV care and treatment strategies for achieving the UNAIDS 2030 targets of 95-95-95 in the midst of the SARS-CoV-2 pandemic and changes in public health funding priorities. Our central hypothesis is that retention in the HIV care cascade and treatment outcomes are influenced by patient-level demographic, clinical, developmental, and behavioral factors, as well as, factors within the ambient health care and broader contextual environment. We will leverage our strengths, including robust working relationships with HIV treatment programs, a substantial harmonized regional database, plus broad experience in sampling-based methodologies and novel analytical approaches. Over the course of this research we will: SA-1: Describe movement through the HIV care cascade with a focus on identifying broader and health care environment contextual factors that influence optimal retention in care and viral suppression, in the face of global disruption due to the COVID-19 pandemic and changes in donor funding priorities. The Post COVID-19 Double-Sampling Cohort (Post COVID) will address the impact of broader contextual factors (COVID-19) while the Telehealth and Structural Adaptations project will address the impact of health care structure. SA-2: Examine the impact of developmental stage and behavioral factors on retention in the cascade and subsequent outcomes. The multiregional Adolescent and Young Adult Network of IeDEA (AYANI) and regional Measuring Adverse Pregnancy and Newborn Congenital Outcomes (MANGO) cohorts will assess the impact of developmental stage on the cascade, while the Syndemics cohort will address the impact of mental health on the cascade.SA- 3: Examine the immediate and long-term outcomes of people diagnosed with Tuberculosis (TB) with a focus on identifying and addressing factors associated with patient outcomes. The multiregional TB Sentinel Research Network (TB-SRN) will focus on understanding TB outcomes and long-term pulmonary complications including associated factors. SA-4: Explore the use of new technologies, including eHealth and machine (deep) learning to diagnose and manage HIV-associated cancers with a focus on Kaposi’s Sarcoma (KS) and Cervical Cancer. The KS Project will assess implementation of a Dermatology Telehealth Program and the Cervical Cancer Project will assess the implementation of cervical image capture with machine learning for cancer diagnoses and management. SA-5: Examine the epidemiology of NCD comorbidities and ART complications with a focus on the oldest and youngest-age groups affected by HIV. The multi-regional Sentinel Research Network (SRN) will address non-communicable diseases in people living with HIV (PLHIV) > 40 years and the regional MANGO Cohort will address complications of ART/HIV exposure on HIV-Exposed Infants.

项目概要/摘要： 我们的主要目标仍然是为临床医生、政府、 项目和国际组织认为， 艾滋病毒护理和治疗战略，以实现联合国艾滋病规划署2030年95-95-95的目标， SARS-CoV-2大流行和公共卫生资金优先事项的变化。我们的核心假设是， 在艾滋病毒护理级联中的保留和治疗结果受到患者层面人口统计学的影响， 临床，发育和行为因素，以及环境卫生保健和更广泛的因素 上下文环境。我们将利用我们的优势，包括与艾滋病毒的强有力的工作关系 治疗方案，一个实质性的协调区域数据库，加上广泛的经验，抽样为基础的 方法和新的分析方法。在本研究过程中，我们将：SA-1：描述 通过艾滋病毒护理级联运动，重点是确定更广泛的卫生保健环境， 面对全球性破坏，影响最佳护理保留和病毒抑制的背景因素 由于COVID-19疫情及捐助者资金优先次序的变化。COVID-19后的双重采样 队列（后COVID）将解决更广泛的背景因素（COVID-19）的影响，而远程医疗 和结构调整项目将解决卫生保健结构的影响。SA-2：检查影响 的发展阶段和行为因素的保留在级联和随后的结果。的 多区域青少年和青年成人网络（AYANI） 妊娠和新生儿先天性结局（MANGO）队列将评估 在级联阶段，而Syndemics队列将解决心理健康对级联的影响。 3：检查被诊断患有结核病（TB）的人的直接和长期结果， 重点是识别和解决与患者结局相关的因素。多区域结核病哨兵 研究网络（TB-SRN）将侧重于了解结核病的结果和长期肺结核 并发症包括相关因素。SA-4：探索使用新技术，包括电子健康 和机器（深度）学习来诊断和管理艾滋病毒相关的癌症，重点是卡波西的 肉瘤（KS）和宫颈癌。KS项目将评估皮肤病学远程保健的实施情况， 计划和宫颈癌项目将评估宫颈图像采集的实施情况， 机器学习用于癌症诊断和管理。SA-5：审查非传染性疾病的流行病学 合并症和抗逆转录病毒疗法并发症，重点是受艾滋病毒影响的最老和最高龄群体。 多区域哨点研究网络（Sentinel Research Network，SRN）将解决生活在非洲的人们的非传染性疾病问题。 艾滋病毒感染者（艾滋病毒感染者）> 40岁，区域MANGO队列将解决ART/艾滋病毒暴露的并发症 艾滋病暴露的婴儿。