Research Training in Chemistry and Chemical Biology

化学和化学生物学研究培训

• 批准号: 10410908
• 负责人: Jason E Gestwicki
• 金额: $ 62.44万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10410908
• 关键词: Biology; Chemicals; Chemistry; Research Training

Project Summary The goal of the UCSF Chemistry and Chemical Biology (CCB) predoctoral training program is to foster research in the use of chemical strategies to probe fundamental biological questions. The overall program curriculum focuses on: 1) rigorous didactic and hands-on training courses at the chemistry-biology interface in the first year; 2) research rotations in three different labs during that same year; 3) selection of a thesis advisor and development of an independent research proposal at the end of the first year; 4) an intensive oral qualifying exam in the second year; 5) individual thesis research with a focus on impact, collaboration and publication and finally; 6) a dissertation seminar. Integrated throughout this training program, from the first day to the last, are activities that train and encourage trainees to: i) develop skills in responsible conduct of research (RCR), rigor & reproducibility and chemical and biological safety; ii) openly receive and give feedback through evaluation and assessment tools; iii) foster career interests, including use of Individual Development Plans (IDPs); iv) enhance written and oral communication skills; (v) celebrate diversity and a sense of community and vi) gain training in critical analysis via journal clubs, seminars and minicourses. The research in the CCB program is highly inter- disciplinary and broadly categorized as: biological chemistry and synthetic biology, computational chemistry and biology, chemical synthesis and natural products, drug discovery and design, macromolecular structure and function and protein and cellular engineering. To enact this training program, the CCB program is not associated with a specific department; rather, we bring together 48 faculty from nine different academic departments and two research institutes across UCSF’s world-class research enterprise. These faculty are rigorously and holistically evaluated by the CCB Executive Committee, for excellence in research, mentoring and commitment to diversity, and these faculty are required to complete annual mentor training. They are among the best scientists in the world (3 HHMI Investigators, 10 NAS members; Lasker, Kavli Prize winners; avg $808,000/yr in funding). Oversight of the CCB program is maintained by the Executive Committee, along with an engaged Dean of the UCSF Graduate School and an expert External Advisory Committee. This CBI proposal builds on 20+ years of educational excellence at the chemistry-biology interface and it has no equivalent elsewhere on the UCSF campus. Approximately 12 students are enrolled annually from a pool of ~220 applicants after a rigorous application process that culminates in personal interviews. Enrolled students from under-represented minority (URM) groups now represent ~16% of the total, with an overall M/F ratio of ~50%. The URM candidates, those from disadvantaged backgrounds and students with disabilities are actively sought in an extensive series of outreach programs, including Science Education Partnership (SEP), an undergraduate Summer Research Training Program (SRTP) and the PROPEL post-bac program. Our graduates are highly sought-after in academia, industry and beyond, because of their training, creativity and passion for inter-disciplinary science.

项目摘要 UCSF化学和化学生物学（CCB）博士前培训计划的目标是促进研究 使用化学策略来探索基本的生物学问题。整体课程计划 侧重于：1）第一年在化学-生物学界面上进行严格的教学和实践培训课程; 2)在同一年在三个不同的实验室进行研究轮换; 3）选择论文导师， 在第一年结束时制定独立的研究计划; 4）密集的口头资格 第二年考试; 5）个人论文研究，重点是影响，合作和出版， 最后; 6）论文研讨会。在整个培训计划中，从第一天到最后一天， 培训和鼓励学员的活动：i）培养负责任的研究行为（RCR），严谨性和 可重复性和化学和生物安全性; ii）通过评价公开接受和提供反馈， 评估工具; iii）培养职业兴趣，包括使用个人发展计划（IDP）; iv）加强 书面和口头沟通技能;（五）庆祝多样性和社区意识，以及（六）获得以下方面的培训 通过期刊俱乐部、研讨会和小型课程进行批判性分析。在CCB计划的研究是高度相互- 学科和广泛分类为：生物化学和合成生物学，计算化学和 生物学、化学合成和天然产物、药物发现和设计、大分子结构和 功能和蛋白质及细胞工程。要制定此培训计划，CCB计划不与 与一个特定的部门;相反，我们汇集了来自九个不同学术部门的48名教师， UCSF世界级研究企业的两个研究机构。这些教师是严格和 由CCB执行委员会进行全面评估，以表彰其在研究、指导和承诺方面的卓越表现 多样性，这些教师必须完成年度导师培训。他们是最好的 科学家（3名HHMI调查员，10名NAS成员; Lasker，Kavli奖获得者;年平均808，000美元 资金）。CCB计划的监督由执行委员会与一位敬业的院长沿着维护 加州大学旧金山分校研究生院和一个专家外部咨询委员会。CBI提案基于20+ 多年的教育卓越的化学生物学接口，它没有相当于其他地方的 加州大学旧金山分校。每年大约有12名学生从220名申请者中入学，经过严格的审查。 申请过程在个人面试中达到高潮。入学人数不足的少数民族学生 (URM)目前，妇女群体占总数的约16%，总体男女比例约为50%。URM候选人，这些 来自弱势背景和残疾学生积极寻求在一个广泛的系列， 外展计划，包括科学教育伙伴关系（SEP），本科生暑期研究 培训计划（SRTP）和PROPEL post-bac计划。我们的毕业生是非常抢手的， 学术界、工业界及其他领域，因为他们的培训、创造力和对跨学科科学的热情。