Research Training in Chemistry and Chemical Biology

项目摘要 加州大学化学与化学生物学(CCB)博士前培训计划的目标是促进研究 使用化学策略来探索基本的生物学问题。整体计划课程 重点是：1)第一年在化学-生物界面上严格的教学和动手培训课程； 2)同一年在三个不同实验室的研究轮换；3)选择论文顾问和 在第一年结束时制定独立研究计划；4)密集的口语资格赛 二年级考试；5)个人论文研究，注重影响、合作和发表 6)论文研讨会。在整个培训计划中，从第一天到最后一天， 培训和鼓励学员的活动：i)培养负责任的研究(RCR)、严谨和 可再现性以及化学和生物安全；二)公开接受和提供反馈，通过评估和 评估工具；三)培养职业兴趣，包括利用个人发展计划；四)加强 书面和口头沟通技能；(V)颂扬多样性和社区意识；vi)在 通过期刊俱乐部、研讨会和小型课程进行批判性分析。中国建设银行项目的研究具有很强的互动性。 学科和广泛分类为：生物化学和合成生物学，计算化学和 生物学、化学合成和天然产物、药物发现和设计、大分子结构和 功能、蛋白质和细胞工程。为执行此培训计划，建行计划未关联 相反，我们汇集了来自9个不同学术部门的48名教职员工， 两家研究机构横跨加州大学旧金山分校的世界级研究企业。这些教职员工都是严格和 由建行执行委员会对研究、指导和承诺方面的卓越表现进行全面评估 这些教师必须完成年度导师培训。他们是名列前茅的 世界科学家(3名HHMI调查人员，10名NAS成员；Lasker，Kavli奖获得者；年平均80.8万美元 资金)。对建行项目的监督由执行委员会与一名聘用的院长共同维持 加州大学旧金山分校研究生院和一个专家外部咨询委员会。这份CBI提案建立在20+ 多年来在化学-生物界面的卓越教育，它在其他地方没有类似的 加州大学旧金山分校。每年从大约220名申请者中招收大约12名学生，经过严格的 申请过程最终以个人面试告终。来自代表性不足的少数族裔的入学学生 (URM)组现在占总数的约16%，总体M/F比约为50%。城市轨道交通考生，那些 在一系列广泛的活动中，积极寻找来自贫困背景和残疾学生 外展计划，包括科学教育伙伴关系(SEP)，本科生暑期研究 培训计划(SRTP)和PURPEL后BAC计划。我们的毕业生在中国很受欢迎 学术界、工业界和其他方面，因为他们对跨学科科学的培训、创造力和热情。

Project Summary The goal of the UCSF Chemistry and Chemical Biology (CCB) predoctoral training program is to foster research in the use of chemical strategies to probe fundamental biological questions. The overall program curriculum focuses on: 1) rigorous didactic and hands-on training courses at the chemistry-biology interface in the first year; 2) research rotations in three different labs during that same year; 3) selection of a thesis advisor and development of an independent research proposal at the end of the first year; 4) an intensive oral qualifying exam in the second year; 5) individual thesis research with a focus on impact, collaboration and publication and finally; 6) a dissertation seminar. Integrated throughout this training program, from the first day to the last, are activities that train and encourage trainees to: i) develop skills in responsible conduct of research (RCR), rigor & reproducibility and chemical and biological safety; ii) openly receive and give feedback through evaluation and assessment tools; iii) foster career interests, including use of Individual Development Plans (IDPs); iv) enhance written and oral communication skills; (v) celebrate diversity and a sense of community and vi) gain training in critical analysis via journal clubs, seminars and minicourses. The research in the CCB program is highly inter- disciplinary and broadly categorized as: biological chemistry and synthetic biology, computational chemistry and biology, chemical synthesis and natural products, drug discovery and design, macromolecular structure and function and protein and cellular engineering. To enact this training program, the CCB program is not associated with a specific department; rather, we bring together 48 faculty from nine different academic departments and two research institutes across UCSF’s world-class research enterprise. These faculty are rigorously and holistically evaluated by the CCB Executive Committee, for excellence in research, mentoring and commitment to diversity, and these faculty are required to complete annual mentor training. They are among the best scientists in the world (3 HHMI Investigators, 10 NAS members; Lasker, Kavli Prize winners; avg $808,000/yr in funding). Oversight of the CCB program is maintained by the Executive Committee, along with an engaged Dean of the UCSF Graduate School and an expert External Advisory Committee. This CBI proposal builds on 20+ years of educational excellence at the chemistry-biology interface and it has no equivalent elsewhere on the UCSF campus. Approximately 12 students are enrolled annually from a pool of ~220 applicants after a rigorous application process that culminates in personal interviews. Enrolled students from under-represented minority (URM) groups now represent ~16% of the total, with an overall M/F ratio of ~50%. The URM candidates, those from disadvantaged backgrounds and students with disabilities are actively sought in an extensive series of outreach programs, including Science Education Partnership (SEP), an undergraduate Summer Research Training Program (SRTP) and the PROPEL post-bac program. Our graduates are highly sought-after in academia, industry and beyond, because of their training, creativity and passion for inter-disciplinary science.