Genetic Approaches to Development and Disease

项目摘要 该提案介绍了一个新的博士培训计划，遗传方法的发展和疾病 （GADD）在哥伦比亚大学欧文医学中心（CUIMC），该中心培训年轻科学家使用 现代遗传学解决生物医学研究的重大挑战。必须有具体的 由于普遍使用遗传学上易于处理的模式生物， 现代遗传技术的发展，以及哺乳动物系统中基因组分析的复杂性， 包括人类患者。性别问题与发展方案就是为满足这一需要而设计的。 GADD项目的学生接受使用模式生物进行遗传分析的高级培训， 当前的遗传学和基因组学技术，生物统计学，遗传学史，现代遗传学伦理。 GADD培训计划作为一个高度选择性的培训计划，汇集了动态的，良好的- 来自哥伦比亚大学各系和研究中心的受资助教师和优秀学生 基于他们的主题契合、严谨的研究和指导能力。该培训计划具有严格的 课程强调批判性思维和写作和表达技能的发展，以及 定期反馈和个性化指导每个学生。在我们的教师培训实验室的学员谁拥有 在过去五年毕业的学生表现出出色的培训成果，有合理的时间学位（略低于6 年），高比例的资助奖（26%）和第一作者出版物（97%），以及成功的研究， 教育或研究相关的职业（94%）。性别问题与发展方案的一个主要目标是使 通过有效的招聘，保留和支持生物医学劳动力：URM学生占16%， 现在的学生。拟议的性别问题与发展处培训赠款将提供学术、社会和职业发展 通过结构化的培训活动和密切监测学生的进步， 将取代以前的遗传学和发展（G & D）培训补助金。总的来说，GADD计划 代表了一个首屈一指的遗传学为重点的研究生课程，有一个长期的成功训练记录 该中心的目标是培养生物医学研究领域的领导者，并制定一项现代培训计划，以便在未来继续做出贡献。

PROJECT SUMMARY This proposal describes a new PhD training program, Genetic Approaches to Development and Disease (GADD) at Columbia University Irving Medical Center (CUIMC), which trains young scientists in the use of modern genetics to address major challenges in biomedical research. There is an essential need for specific training of PhD students in genetic approaches due to the prevalent use of genetically tractable model organisms, the evolution of modern genetic techniques, and the complexities of genomic analyses in mammalian systems, including human patients. The GADD program has been designed to meet this need. Students in the GADD program receive advanced training in genetic analyses using model organisms, current genetic and genomic techniques, biostatistics, history of genetics, and the ethics of modern genetics. The GADD training program functions as a highly selective training program that draws together dynamic, well- funded faculty and outstanding students from departments and research centers across Columbia University based on their thematic fit, rigorous research, and mentoring abilities. The training program features a rigorous curriculum that emphasizes critical thought and development of writing and presentation skills, together with regular feedback and individualized mentoring of each student. Trainees in our faculty training labs who have graduated in the last five years show excellent training outcomes, with reasonable time-to-degree (just under 6 years), a high percentage of funding awards (26%) and first-author publications (97%), and successful research, educational, or research-related careers (94%). A major goal of the GADD program is diversification of the biomedical workforce through effective recruitment, retention, and support: URM students represent 16% of current students. The proposed GADD training grant will provide academic, social, and career development support to all of its students through structured training activities and close monitoring of student progress and will replace the previous Genetics and Development (G&D) training grant. Overall, the GADD program represents a premier genetics-focused graduate program that has a long track-record of success in training leaders in biomedical research and a modern training plan to continue its contributions in the future.