Hyperpolarized MRI Technology Resource Center

超极化 MRI 技术资源中心

• 批准号: 10410334
• 负责人: Daniel B Vigneron
• 金额: $ 17.58万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10410334
• 关键词: Magnetic Resonance Imaging; Resources; Technology

Administration Project Summary/Abstract The Hyperpolarized MRI Technology Resource Center (HMTRC) is designed to be timely, nimble and highly productive in the development of new hyperpolarized (HP) MR instrumentation, techniques, acquisition and analysis software through push-pull interactions with Collaborative Project (CP) investigators. In parallel, another key goal of the center is to disseminate these newly developed technologies to the Service Project (SP) Investigators for extramural feedback and to the general scientific community through the new website, symposia/seminar, monthly newsletter, annual HP MR Technology Workshops, and hands-on training. In order to accomplish all these goals and functions, a carefully-constructed administrative plan has been developed & refined over the past 10 years, with a clearly defined, but dynamic structure that can be modified to meet new challenges and changing collaborative, service, training and dissemination needs. This has required a detailed organizational structure to enable “team decision-making”, so that each member of the team can provide their specialized input for optimal technology development and translation to address unmet scientific and/or clinical needs. The HMTRC administrative structure and implementation have evolved considerably since the original submission as the interactions and complexity of the P41 have increased dramatically over the past ten years. These improvements have also benefited from great institutional support, input from many experienced sources including the external advisory committee (EAC), leading experts in HP technology, the HP Radiologist Leadership & Translational Advisory committees, NIBIB Program Staff, and interactions with other P41 centers. The HMTRC administrative infrastructure now extends nationally to provide information, dissemination of novel technologies to CPs, SPs, and other investigators conducting HP 13C MRI preclinical and clinical research. As stated in their attached report: “The EAC … is unanimous in their assessment that the HMTRC is high functioning as an NCBIB. The HMTRC has led the nation (and the world) in the development and translation of HP MRI through a unique combination of skills, expertise, instrumentation, environment, clinical engagement, and industry engagement, which simply does not exist elsewhere. The HMTRC will continue to serve as a critical national resource through the next funding cycle as the field of HP MRI expands and matures, particularly with the clinical translation of new HP agents, and more sites engaging in research involving human subjects. The restructured Center benefits from clear and enhanced synergy between all TR&Ds and Collaborative Projects that are more broadly geographically distributed”.

管理项目摘要/摘要 超极化MRI技术资源中心（HMTRC）设计为及时，敏捷且高度 在开发新的超极化（HP）MR仪器，技术，采集和 通过与协作项目（CP）调查人员的推动互动进行分析软件。并行，另一个 该中心的主要目标是将这些新开发的技术传播到服务项目（SP） 通过新网站向普通科学界进行壁外反馈的研究者， 研讨会/研讨会，每月通讯，年度HP MR技术研讨会和动手培训。为了 为了实现所有这些目标和职能，已经制定了精心构建的行政计划＆ 在过去的十年中，精致了，具有明确的定义但动态的结构，可以修改以满足新的 挑战和不断变化的协作，服务，培训和传播需求。这需要详细 组织结构以实现“团队决策”，以便团队的每个成员都可以提供他们的 用于最佳技术开发和翻译的专业输入，以解决未经核对的科学和/或临床 需要。 HMTRC的管理结构和实施已经仔细地发展 在过去的十年中，随着p41的相互作用和复杂性的提交急剧增加。 这些改进也受益于大力的机构支持，来自许多经验丰富的来源的意见 HP射线科医生包括HP技术领先专家，包括外部咨询委员会（EAC） 领导力与转化咨询委员会，尼比布计划人员以及与其他P41中心的互动。 HMTRC行政基础设施现在在全国范围内扩展，以提供信息，传播新颖 CPS，SPS和其他进行HP 13C MRI临床前和临床研究的研究人员。作为 在他们的附带报告中说：“ EAC…一致评估HMTRC的功能很高 作为ncbib。 HMTRC领导着全国（以及世界）在HP MRI的发展和翻译方面 通过独特的技能，专业知识，仪器，环境，临床参与以及 行业参与，在其他地方根本不存在。 HMTRC将继续作为关键 随着HP MRI领域的扩展和成熟，国家资源通过下一个资金周期，尤其是在 新的HP药物的临床翻译以及更多参与涉及人类受试者的研究的站点。这 重组中心受益于所有TR＆D和协作项目之间的清晰和增强的协同作用 在地理上分布更广泛”。