Hyperpolarized MRI Technology Resource Center

超极化 MRI 技术资源中心

• 批准号: 10410338
• 负责人: Daniel B Vigneron
• 金额: $ 7.18万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10410338
• 关键词: 2,4-Dinitrophenol; Area; Bioreactors; Carbon; Cell Culture Techniques; Chemistry; Client; Clinical; Clinical Research; Collaborations; Communication; Communities; Computer software; Data; Development; Doctor of Philosophy; Documentation; Dose; Educational workshop; Electronic Mail; Environment; Equipment; Event; Extramural Activities; Faculty; Feedback; Funding; Generations; Geography; Goals; Growth and Development function; Human; Human Resources; Imaging Techniques; Individual; Industry; International; Magnetic Resonance Imaging; Mentors; Methods; Newsletter; Paper; Pharmacy facility; Physiologic pulse; Postdoctoral Fellow; Pre-Clinical Model; Preparation; Production; Protocols documentation; Publications; Radiology Specialty; Recipe; Reporting; Research; Research Personnel; Resources; Sampling; Services; Site; Source; Sterility; Surveys; Techniques; Technology; Test Result; Time; Training; Training Activity; Training Programs; Training Support; Translational Research; Translations; Update; Visit; base; biomedical imaging; clinical translation; design; doctoral student; driving force; equipment acquisition; experience; human subject; imaging approach; imaging modality; instrumentation; interest; lectures; molecular imaging; novel; online resource; outreach; pre-clinical; pre-clinical research; program dissemination; programs; radiological imaging; reconstruction; research study; sabbatical; skills; social media; software development; synergism; technology development; technology research and development; tissue culture; tool; training opportunity; virtual; web site

Training & Dissemination Summary/Abstract The overall goal of this P41 center is to develop and disseminate novel hyperpolarized (HP) 13C MR technologies with requisite training/documentation to advance significantly this emerging molecular imaging approach for both preclinical scientific studies and clinical research. This has always been a critical aspect of the HMTRC and it will continue to develop and grow in new ways within this proposed renewal application. As defined in our Specific Aims, the HMTRC training and dissemination programs are designed to have a broad national impact for the advancement of HP C-13 MRI technology development and research. As stated in the 2021 EAC report: “The HMTRC has led the nation (and the world) in the development and translation of HP MRI through a unique combination of skills, expertise, instrumentation, environment, clinical engagement, and industry engagement, which simply does not exist elsewhere. The HMTRC will continue to serve as a critical national resource through the next funding cycle as the field of HP MRI expands and matures, particularly with the clinical translation of new HP agents, and more sites engaging in research involving human subjects. The restructured Center benefits from clear and enhanced synergy between all TR&Ds and Collaborative Projects that are more broadly geographically distributed. HMTRC programs for training and dissemination remain outstanding. Progress in the engagement and stimulation of clinical interest is nothing short of remarkable, and crucial for the continuing growth and development of this field.” This NCBIB’s Training & Dissemination in HP C-13 MRI will focused on: 1) Hands-on and formal course training of local MS/PhD students, post-docs, Radiology residents and fellows. 2) Collaborative Project (CP) investigators will receive specialized training relevant to their particular needs. 3) Junior Faculty will receive support by the department and HMTRC for specific training and mentoring to establish independent HP C-13 research programs. 4) Extramural Visitors from over 55 different sites have come to the HMTRC through the workshops, and longer individual visits to see the latest hardware & receive hands-on training and this would be expanded. 5) Hyperpolarized MRI Technology Workshops. These "hands-on" workshops provide unique information, training, and interactions focused on the technical aspects of HP 13C MR preclinical and translational research and analysis from all TRDs. 6) New Center Website will be a key component in the dissemination & training of tools, resources and technologies developed by this NCBIB. In this renewal, we will expand virtual training by providing new videos and documentation on HP 13C MR technology developments, “How-to” tutorials, training modules and recorded workshop, course lectures, & HP 13C seminar presentations. Also direct technology dissemination to CPs, SPs, & the wider HP 13C community will be supported.

培训与传播摘要/摘要 这个P41中心的总体目标是开发和传播新型超极化（HP）13C MR技术 借助必要的培训/文档，可以显着推进这种新兴的分子成像方法 临床前科学研究和临床研究。这一直是HMTRC的关键方面 在此拟议的续签应用中，将继续以新的方式发展和发展。如我们的特定所定义 目的，HMTRC培训和传播计划旨在对国家产生广泛的影响 HP C-13 MRI技术开发和研究的进步。如2021年EAC报告中所述：“ HMTRC通过独特的 技能，专业知识，仪器，环境，临床参与和行业参与的结合， 根本不存在其他地方。 HMTRC将继续通过 随着HP MRI领域的扩展和成熟，下一个融资周期，特别是随着临床翻译的成熟 新的HP代理商以及更多参与涉及人类受试者的研究的站点。恢复的中心福利 从所有TR＆D和协作项目之间的清晰和增强的协同作用，这些项目更广泛 地理分布。 HMTRC培训和传播计划仍然出色。进步 参与和对临床兴趣的刺激无非是显着，对于继续 该领域的增长和发展。” NCBIB在HP C-13 MRI中的培训和传播将重点放在：1）动手和正式课程培训 当地的MS/博士学位学生，培训后，放射学居民和研究员。 2）合作项目（CP）调查人员 将获得与他们的特定需求相关的专业培训。 3）初级教师将获得 部门和HMTRC进行特定的培训和心理，以建立独立的HP C-13研究 程序。 4）来自55个不同地点的壁外访客通过研讨会来到HMTRC， 而且个人访问更长的时间，以查看最新的硬件并接受动手培训，这将得到扩展。 5）超极化MRI技术研讨会。这些“动手”研讨会提供了独特的信息， 培训以及互动侧重于HP 13C MR临床前和翻译研究的技术方面 和所有TRD的分析。 6）新中心网站将是传播和培训的关键组成部分 该NCBIB开发的工具，资源和技术。在此续约中，我们将扩展 提供有关HP 13C MR技术开发，“操作方法”教程，培训的新视频和文档 模块和记录的研讨会，课程讲座和HP 13C开创性演示。也直接技术 将支持向CPS，SPS和更广泛的HP 13C社区传播。