Training in Developmental Biology, Stem Cells and Regeneration

发育生物学、干细胞和再生培训

• 批准号: 10410302
• 负责人: Gage D Crump
• 金额: $ 20.55万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10410302
• 关键词: Developmental Biology; Training; stem cell self renewal

This application is for renewal for a third cycle of a Predoctoral Training Program in Developmental Biology, Stem Cells, and Regeneration at the University of Southern California (USC). This training program has both benefitted from and contributed to the dramatic growth of stem cell biology and regenerative medicine research at USC Keck School of Medicine. The presence of a dedicated Department of Stem Cell Biology and Regenerative Medicine that has been actively recruiting new faculty, a highly successful PhD Program in Development, Stem Cells, and Regeneration (DSR) that now averages ~15 new entering students per year, and a university-wide USC Stem Cell initiative makes for a highly dynamic, ideal training environment for students. The training program is designed to provide cohesive, structured training in developmental and stem cell biology, coupled with training-grant-specific courses and activities that provide in-depth exposure to clinical problems and advanced bioinformatics. Such a program will best train a future generation of scientists that wish to apply their foundational research in developmental and stem cell biology to the field of regenerative medicine. A unique strength of this training program is that it provides added value, beyond the DSR program, in the form of clinical exposure. Each trainee is paired with a Clinical Co-Mentor, who guides the student in learning about the diseases to which their primary research relates. Trainees take a T32-specific seminar class led by clinician scientists, as well as a hands-on workshop in USC’s new GMP facility that exposes students to manufacturing of clinical-grade stem cells and gene therapy reagents. This exposure of students to how stem cells can address unmet clinical needs is aided by close ties of USC with one of the largest public hospitals in the country, and the extensive participation of clinician-scientists in all aspects of the training program. Recently, we have also partnered with the Department of Quantitative and Computational Biology to offer specialized computational biology training, in direct response to feedback from trainees. During the previous four years of the training program, the 16 funded trainees have published 30 manuscripts in journals such as Cell Stem Cell, Developmental Cell, PNAS, Neuron, and PLoS Biology, and have received four NIH F31 fellowships. Of the 30 trainees since T32 inception, 16 have graduated and 13 remain in training. All graduates have remained in science-intensive positions, with 7 performing postdocs, 6 entering industry, 3 pursuing science policy and journalism, and 1 recently accepting a tenure-track assistant professorship at UCLA. From the first to second funding period, we have increased diversity in our program (12.5% to 25% URM), success of NIH F31s (2 to 4), and the number of students in the main DSR feeder program (~6 to ~15 per year), while decreasing time to degree (6.5 to 5.1 years). The students have hosted a major symposium each year, including virtually during the pandemic, and we have instituted an overnight Annual Retreat as of 2019. The cohesive structure of this training program provides an extra level of clinical fluency that the trainees would not otherwise have obtained through the DSR feeder program alone.

本申请是为更新的第三周期的博士前培训计划在发育生物学， 干细胞和再生在南加州大学（USC）。这个培训计划两者兼而有之 受益于并促进了干细胞生物学和再生医学研究的急剧增长 在南加州大学凯克医学院一个专门的干细胞生物学系的存在， 再生医学一直在积极招募新的教师，一个非常成功的博士课程， 发展，干细胞和再生（DSR），现在平均每年约有15名新入学的学生， 一个大学范围内的南加州大学干细胞计划为学生提供了一个高度动态，理想的培训环境。 该培训计划旨在提供发育和干细胞生物学方面的有凝聚力的结构化培训， 再加上培训补助金的具体课程和活动，提供深入接触临床问题， 先进的生物信息学这样的计划将最好地培养未来一代的科学家，他们希望运用他们的知识， 从发育和干细胞生物学的基础研究到再生医学领域。一个独特 该培训计划的优势在于，它提供了附加值，超越DSR计划，以临床的形式， exposure.每名学员都与一名临床共同导师配对，指导学生了解疾病 与他们的主要研究有关。学员参加由临床科学家领导的T32特定研讨班， 以及在南加州大学的新GMP设施，使学生接触到临床级的生产实践车间 干细胞和基因治疗试剂。这种暴露的学生如何干细胞可以解决未满足的临床 南加州大学与全国最大的公立医院之一的密切联系，以及广泛的 临床科学家参与培训计划的各个方面。最近，我们还与 定量和计算生物学系提供专业的计算生物学培训， 直接回应学员的反馈。在过去四年的培训计划中， 学员在Cell Stem Cell、Developmental Cell、PNAS、Neuron等期刊上发表论文30篇， 和PLoS Biology，并获得了四个NIH F31奖学金。自T32开始以来的30名受训人员中，有16人 已毕业，13人仍在接受培训。所有毕业生都留在了科学密集型的职位上， 执行博士后，6进入工业，3追求科学政策和新闻，和1最近接受了 加州大学洛杉矶分校的终身助理教授从第一个到第二个融资期， 我们计划的多样性（12.5%至25% URM），NIH F31的成功（2至4）以及学生人数 主要DSR馈线程序（每年约6至约15个），同时减少学位时间（6.5至5.1年）。学生 我们每年都主办一次重要的研讨会，包括在大流行期间举办的虚拟研讨会，我们还建立了一个 截至2019年的隔夜年度务虚会。该培训计划的内聚结构提供了一个额外的水平， 临床流畅性，否则受训者不会通过DSR馈线程序单独获得。