Training in Developmental Biology, Stem Cells and Regeneration

本申请书用于续订发育生物学、干细胞和 再生(DSR)，由南加州大学凯克学院管理 医学，与洛杉矶儿童医院的附属教员合作。这项培训计划 利用南加州大学最近在干细胞生物学和再生医学方面的显著增长，这是 反映在创建一个新的干细胞生物学和再生医学系和一个 大学范围内的南加州大学干细胞倡议，正在投资大笔资金招募世界领导人和 有前途的初级教员。与培训相关的研究的特殊优势，受益于与 位于附近的研究所和全国最大的公立医院之一，包括骨骼生物学、神经 和感觉系统，肾脏，消化和代谢器官，以及癌症干细胞。这样做的理由是 培训方案是在基础发育和干细胞生物学方面有凝聚力的、有条理的培训，再加上 通过提供深入了解临床问题的培训赠款特定课程和活动，将是最好的 培养再生医学领域的未来一代科学家。这次训练的一大优势 该计划是在新创建的DSR博士学位的基础上，以临床暴露的形式提供附加值 程序。具体地说，每个实习生都有一名临床联合导师，指导学生学习 关于他们的主要研究涉及的疾病。在培训计划的头四年里， 这10名受训人员，加上另外4名由教务长办公室资助的受训人员，将发表30份 第一作者手稿，获得了NIH F31奖学金，并获得了许多荣誉和奖项。这个 大多数学员第一次进入南加州大学是通过生物医学和生物科学(PIBBS)项目 招生计划，该计划的培训拨款资格申请者的质量稳步上升。在… 第一年结束时，学生们进入我们26名培训教师之一的实验室，攻读DSR博士学位。 计划，并参加一个关于发育和干细胞生物学的暑期强化核心课程，然后 杂志俱乐部和研究报告课程在他们的第二年。在正式征集申请之后 和外部审查，选择学生在他们的第二年，有时是第三年参加T32培训计划， 在这一点上，他们参加了再生医学课程的实习生特定的临床视角，并从事 一系列针对实习生的活动，包括一年一度的静修，学生主导的研讨会，经常 与临床导师的互动，以及每月的午餐聚会。这次培训的衔接结构 该计划提供了一个额外的临床流利性水平，否则受训者不会通过 光是DSR项目。通过利用邻近洛杉矶地区独特的临床资源 随着南加州大学最近在基础干细胞研究方面的增长，这一培训计划提供了重点教育 为那些希望在再生医学领域产生未来影响的有前途的年轻科学家提供经验。

This application is for renewal of a Predoctoral Training Program in Developmental Biology, Stem Cells, and Regeneration (DSR), which is administered at the University of Southern California (USC) Keck School of Medicine, in conjunction with affiliated faculty at the Children's Hospital Los Angeles. This training program leverages recent and dramatic growth in stem cell biology and regenerative medicine at USC, which is reflected in the creation of a new Department of Stem Cell Biology and Regenerative Medicine and a university-wide USC Stem Cell initiative that is investing large sums of money to recruit world leaders and promising junior faculty. Particular strengths of training-related research, which benefit from interactions with closely situated institutes and one of the largest public hospitals in the country, include skeletal biology, neural and sensory systems, kidney, digestive and metabolic organs, and cancer stem cells. The rationale of this training program is that cohesive, structured training in basic developmental and stem cell biology, coupled with training-grant-specific courses and activities that provide in-depth exposure to clinical problems, will best train the future generation of scientists in the field of regenerative medicine. A major strength of this training program is that it provides added value, in the form of clinical exposure, on top of a newly created DSR PhD program. In particular, each trainee is paired with a Clinical Co-Mentor, who guides the student in learning about the diseases to which their primary research relates. During the first four years of the training program, the ten funded trainees, plus an additional four trainees funded by the Dean's office, will have published 30 first-author manuscripts, received an NIH F31 fellowship, and won a number of honors and awards. The majority of trainees first enter USC through a Program in Biomedical and Biological Sciences (PIBBS) umbrella admissions program, which has seen a steady rise in the quality of its training-grant-eligible applicant pool. At the end of their first year, students join the lab of one of our 26 training faculty, matriculate in the DSR PhD program, and take an intensive summer core course in developmental and stem cell biology, followed by journal club and research presentation courses in their second year. Following a formal call for applications and external review, select students join the T32 training program in their second and sometimes third years, at which point they take a trainee-specific Clinical Perspective of Regenerative Medicine course and engage in a number of trainee-specific activities including an annual retreat, a student-led symposium, frequent interactions with their clinical co-mentor, and monthly lunch gatherings. The cohesive structure of this training program provides an extra level of clinical fluency that the trainees would not otherwise have obtained through the DSR program alone. By leveraging the unique clinical resources within the neighboring Los Angeles area with the recent growth in basic stem cell research at USC, this training program provides a focused educational experience for those promising young scientists who wish to make a future impact in regenerative medicine.