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Animal Tumor Models

动物肿瘤模型

基本信息

批准号：
10411090
负责人：
Vittorio Sebastiano
金额：
$ 9.1万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-06-04 至 2027-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10411090
关键词：
Algorithm Design Animal Model Animals Antibodies Area Biological Assay Budgets CRISPR/Cas technology Cancer Biology Cancer Center Support Grant Collaborations Cryoultramicrotomy Custom DNA Data Analyses Data Collection Drug Kinetics Fostering Funding Genetic Engineering Goals Guide RNA Histology Histopathology Image Immunohistochemistry Inbred BALB C Mice Institutes Knock-in Knock-out Knockout Mice Laboratories Magnetic Resonance Imaging Malignant Neoplasms Measurement Mediating Medicine Modality Modeling Mouse Strains Oncology Paraffin Pathologic Pathologist Pharmaceutical Preparations Pharmacodynamics Positron-Emission Tomography Production Protocols documentation Publications Research Research Design Research Personnel Resource Sharing Savings Series Service delivery model Services Sirius Red F3B Stains Surveys Technology Therapeutic Tissues Titrations Transgenic Animals Transgenic Mice Transgenic Organisms Translating Xenograft procedure animal resource base bioluminescence imaging cancer imaging cancer stem cell comparative cost cost effective cresyl violet design and construction experimental study genome editing member mouse genome mouse model oncology service pre-clinical preservation programs success tissue processing tumor

项目摘要

PROJECT SUMMARY The Animal Tumor Models Shared Resource (ATM-SR) provides services in three major areas: (i) transgenic and knockout mice, (ii) preclinical oncology, and (iii) animal histopathology services. The primary goal of the ATM-SR is to facilitate high-impact cancer-relevant research done by Stanford Cancer Institute (SCI) members by providing state-of-the-art and comprehensive animal resources. The transgenic and knockout mouse production services were established at Stanford in 1996 with the overall objective of providing genetically modified mouse models and associated supporting technologies to Stanford investigators at cost- effective rates. Preclinical oncology services, including study design, tumor induction, drug administration, PK and PD study, data collection and analysis, were initiated by the SCI in 2007. These services are provided by the Transgenic, Knockout and Tumor Model Center (TKTC). The Veterinary Service Center (VSC) in the Department of Comparative Medicine manages the animal histopathology service component of the shared resource. Major services include tumor analysis by histology, immunohistochemistry and pathological interpretation. Since the last review, the animal histology laboratory underwent a major renovation and expansion. In 2020, 45% of users were SCI investigators. Members from all programs regularly use the ATM- SR, with the heaviest use coming from the Cancer Biology and Cancer Stem Cells and Cancer Therapeutics programs. The ATM-SR contributed to over 17 cancer-focused SCI member publications since 2015; 10 of them were high-impact. The annual budget of the ATM-SR is $1,250,002 yet the CCSG request is $105,312. Accordingly, the ATM-SR leverages extensive institutional support and seeks only 8% from CCSG funds. The ATM-SR is focused on three major scientific aims: (1) to produce transgenic and knockout mice, (2) to provide preclinical oncology model services, and (3) to provide histopathology services.

项目总结