Animal Tumor Models
动物肿瘤模型
基本信息
- 批准号:10411090
- 负责人:
- 金额:$ 9.1万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-06-04 至 2027-05-31
- 项目状态:未结题
- 来源:
- 关键词:Algorithm DesignAnimal ModelAnimalsAntibodiesAreaBiological AssayBudgetsCRISPR/Cas technologyCancer BiologyCancer Center Support GrantCollaborationsCryoultramicrotomyCustomDNAData AnalysesData CollectionDrug KineticsFosteringFundingGenetic EngineeringGoalsGuide RNAHistologyHistopathologyImageImmunohistochemistryInbred BALB C MiceInstitutesKnock-inKnock-outKnockout MiceLaboratoriesMagnetic Resonance ImagingMalignant NeoplasmsMeasurementMediatingMedicineModalityModelingMouse StrainsOncologyParaffinPathologicPathologistPharmaceutical PreparationsPharmacodynamicsPositron-Emission TomographyProductionProtocols documentationPublicationsResearchResearch DesignResearch PersonnelResource SharingSavingsSeriesService delivery modelServicesSirius Red F3BStainsSurveysTechnologyTherapeuticTissuesTitrationsTransgenic AnimalsTransgenic MiceTransgenic OrganismsTranslatingXenograft procedureanimal resourcebasebioluminescence imagingcancer imagingcancer stem cellcomparativecostcost effectivecresyl violetdesign and constructionexperimental studygenome editingmembermouse genomemouse modeloncology servicepre-clinicalpreservationprogramssuccesstissue processingtumor
项目摘要
PROJECT SUMMARY
The Animal Tumor Models Shared Resource (ATM-SR) provides services in three major areas: (i) transgenic
and knockout mice, (ii) preclinical oncology, and (iii) animal histopathology services. The primary goal of the
ATM-SR is to facilitate high-impact cancer-relevant research done by Stanford Cancer Institute (SCI)
members by providing state-of-the-art and comprehensive animal resources. The transgenic and knockout
mouse production services were established at Stanford in 1996 with the overall objective of providing
genetically modified mouse models and associated supporting technologies to Stanford investigators at cost-
effective rates. Preclinical oncology services, including study design, tumor induction, drug administration, PK
and PD study, data collection and analysis, were initiated by the SCI in 2007. These services are provided by
the Transgenic, Knockout and Tumor Model Center (TKTC). The Veterinary Service Center (VSC) in the
Department of Comparative Medicine manages the animal histopathology service component of the shared
resource. Major services include tumor analysis by histology, immunohistochemistry and pathological
interpretation. Since the last review, the animal histology laboratory underwent a major renovation and
expansion. In 2020, 45% of users were SCI investigators. Members from all programs regularly use the ATM-
SR, with the heaviest use coming from the Cancer Biology and Cancer Stem Cells and Cancer Therapeutics
programs. The ATM-SR contributed to over 17 cancer-focused SCI member publications since 2015; 10 of
them were high-impact. The annual budget of the ATM-SR is $1,250,002 yet the CCSG request is $105,312.
Accordingly, the ATM-SR leverages extensive institutional support and seeks only 8% from CCSG funds. The
ATM-SR is focused on three major scientific aims: (1) to produce transgenic and knockout mice, (2) to provide
preclinical oncology model services, and (3) to provide histopathology services.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Vittorio Sebastiano其他文献
Vittorio Sebastiano的其他文献
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{{ truncateString('Vittorio Sebastiano', 18)}}的其他基金
Dissecting the Molecular Role of TBX1 in the Context of Human Pharyngeal Endoderm Development
解析 TBX1 在人咽内胚层发育中的分子作用
- 批准号:
10442889 - 财政年份:2022
- 资助金额:
$ 9.1万 - 项目类别:
Dissecting the Molecular Role of TBX1 in the Context of Human Pharyngeal Endoderm Development
解析 TBX1 在人咽内胚层发育中的分子作用
- 批准号:
10615234 - 财政年份:2022
- 资助金额:
$ 9.1万 - 项目类别:
Single Step Strategy for the Therapeutic Reprogramming in Epidermolysis Bullosa Patients
大疱性表皮松解症患者治疗性重编程的一步策略
- 批准号:
9475196 - 财政年份:2017
- 资助金额:
$ 9.1万 - 项目类别:
Single Step Strategy for the Therapeutic Reprogramming in Epidermolysis Bullosa Patients
大疱性表皮松解症患者治疗重编程的一步策略
- 批准号:
9317254 - 财政年份:2017
- 资助金额:
$ 9.1万 - 项目类别:
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