Animal Tumor Models

动物肿瘤模型

基本信息

  • 批准号:
    10411090
  • 负责人:
  • 金额:
    $ 9.1万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-06-04 至 2027-05-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY The Animal Tumor Models Shared Resource (ATM-SR) provides services in three major areas: (i) transgenic and knockout mice, (ii) preclinical oncology, and (iii) animal histopathology services. The primary goal of the ATM-SR is to facilitate high-impact cancer-relevant research done by Stanford Cancer Institute (SCI) members by providing state-of-the-art and comprehensive animal resources. The transgenic and knockout mouse production services were established at Stanford in 1996 with the overall objective of providing genetically modified mouse models and associated supporting technologies to Stanford investigators at cost- effective rates. Preclinical oncology services, including study design, tumor induction, drug administration, PK and PD study, data collection and analysis, were initiated by the SCI in 2007. These services are provided by the Transgenic, Knockout and Tumor Model Center (TKTC). The Veterinary Service Center (VSC) in the Department of Comparative Medicine manages the animal histopathology service component of the shared resource. Major services include tumor analysis by histology, immunohistochemistry and pathological interpretation. Since the last review, the animal histology laboratory underwent a major renovation and expansion. In 2020, 45% of users were SCI investigators. Members from all programs regularly use the ATM- SR, with the heaviest use coming from the Cancer Biology and Cancer Stem Cells and Cancer Therapeutics programs. The ATM-SR contributed to over 17 cancer-focused SCI member publications since 2015; 10 of them were high-impact. The annual budget of the ATM-SR is $1,250,002 yet the CCSG request is $105,312. Accordingly, the ATM-SR leverages extensive institutional support and seeks only 8% from CCSG funds. The ATM-SR is focused on three major scientific aims: (1) to produce transgenic and knockout mice, (2) to provide preclinical oncology model services, and (3) to provide histopathology services.
项目总结

项目成果

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Vittorio Sebastiano其他文献

Vittorio Sebastiano的其他文献

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{{ truncateString('Vittorio Sebastiano', 18)}}的其他基金

Dissecting the Molecular Role of TBX1 in the Context of Human Pharyngeal Endoderm Development
解析 TBX1 在人咽内胚层发育中的分子作用
  • 批准号:
    10442889
  • 财政年份:
    2022
  • 资助金额:
    $ 9.1万
  • 项目类别:
Dissecting the Molecular Role of TBX1 in the Context of Human Pharyngeal Endoderm Development
解析 TBX1 在人咽内胚层发育中的分子作用
  • 批准号:
    10615234
  • 财政年份:
    2022
  • 资助金额:
    $ 9.1万
  • 项目类别:
Single Step Strategy for the Therapeutic Reprogramming in Epidermolysis Bullosa Patients
大疱性表皮松解症患者治疗性重编程的一步策略
  • 批准号:
    9475196
  • 财政年份:
    2017
  • 资助金额:
    $ 9.1万
  • 项目类别:
Single Step Strategy for the Therapeutic Reprogramming in Epidermolysis Bullosa Patients
大疱性表皮松解症患者治疗重编程的一步策略
  • 批准号:
    9317254
  • 财政年份:
    2017
  • 资助金额:
    $ 9.1万
  • 项目类别:
Animal Tumor Models
动物肿瘤模型
  • 批准号:
    10626972
  • 财政年份:
    2007
  • 资助金额:
    $ 9.1万
  • 项目类别:
Animal Tumor Models
动物肿瘤模型
  • 批准号:
    9113308
  • 财政年份:
  • 资助金额:
    $ 9.1万
  • 项目类别:

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