Animal Tumor Models

动物肿瘤模型

基本信息

批准号：
10411090
负责人：
Vittorio Sebastiano
金额：
$ 9.1万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-06-04 至 2027-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10411090
关键词：
Algorithm Design Animal Model Animals Antibodies Area Biological Assay Budgets CRISPR/Cas technology Cancer Biology Cancer Center Support Grant Collaborations Cryoultramicrotomy Custom DNA Data Analyses Data Collection Drug Kinetics Fostering Funding Genetic Engineering Goals Guide RNA Histology Histopathology Image Immunohistochemistry Inbred BALB C Mice Institutes Knock-in Knock-out Knockout Mice Laboratories Magnetic Resonance Imaging Malignant Neoplasms Measurement Mediating Medicine Modality Modeling Mouse Strains Oncology Paraffin Pathologic Pathologist Pharmaceutical Preparations Pharmacodynamics Positron-Emission Tomography Production Protocols documentation Publications Research Research Design Research Personnel Resource Sharing Savings Series Service delivery model Services Sirius Red F3B Stains Surveys Technology Therapeutic Tissues Titrations Transgenic Animals Transgenic Mice Transgenic Organisms Translating Xenograft procedure animal resource base bioluminescence imaging cancer imaging cancer stem cell comparative cost cost effective cresyl violet design and construction experimental study genome editing member mouse genome mouse model oncology service pre-clinical preservation programs success tissue processing tumor

项目摘要

PROJECT SUMMARY The Animal Tumor Models Shared Resource (ATM-SR) provides services in three major areas: (i) transgenic and knockout mice, (ii) preclinical oncology, and (iii) animal histopathology services. The primary goal of the ATM-SR is to facilitate high-impact cancer-relevant research done by Stanford Cancer Institute (SCI) members by providing state-of-the-art and comprehensive animal resources. The transgenic and knockout mouse production services were established at Stanford in 1996 with the overall objective of providing genetically modified mouse models and associated supporting technologies to Stanford investigators at cost- effective rates. Preclinical oncology services, including study design, tumor induction, drug administration, PK and PD study, data collection and analysis, were initiated by the SCI in 2007. These services are provided by the Transgenic, Knockout and Tumor Model Center (TKTC). The Veterinary Service Center (VSC) in the Department of Comparative Medicine manages the animal histopathology service component of the shared resource. Major services include tumor analysis by histology, immunohistochemistry and pathological interpretation. Since the last review, the animal histology laboratory underwent a major renovation and expansion. In 2020, 45% of users were SCI investigators. Members from all programs regularly use the ATM- SR, with the heaviest use coming from the Cancer Biology and Cancer Stem Cells and Cancer Therapeutics programs. The ATM-SR contributed to over 17 cancer-focused SCI member publications since 2015; 10 of them were high-impact. The annual budget of the ATM-SR is $1,250,002 yet the CCSG request is $105,312. Accordingly, the ATM-SR leverages extensive institutional support and seeks only 8% from CCSG funds. The ATM-SR is focused on three major scientific aims: (1) to produce transgenic and knockout mice, (2) to provide preclinical oncology model services, and (3) to provide histopathology services.

项目摘要动物肿瘤模型共享资源（ATM-SR）在三个主要领域提供服务：（i）转基因和敲除小鼠，（ii）临床前肿瘤学和（iii）动物组织病理学服务。主要目标 ATM-SR将促进斯坦福癌症研究所（SCI）进行的高影响力与癌症相关的研究成员提供最先进和全面的动物资源。转基因和淘汰 1996年在斯坦福大学建立了鼠标生产服务，其总体目的是提供基于成本 - 成本 - 有效费率。临床前肿瘤学服务，包括研究设计，肿瘤诱导，药物管理，PK SCI于2007年启动了PD研究，数据收集和分析。这些服务由转基因，敲除和肿瘤模型中心（TKTC）。兽医服务中心（VSC）比较医学系管理动物组织病理学服务的共享部分资源。主要服务包括组织学，免疫组织化学和病理学分析解释。自上次审查以来，动物组织学实验室进行了重大翻新和扩张。在2020年，有45％的用户是SCI调查人员。所有程序的成员定期使用ATM- SR，最重的用途来自癌症生物学和癌症干细胞和癌症治疗剂程序。自2015年以来，ATM-SR贡献了17多个以癌症为中心的SCI成员出版物； 10 他们很高。 ATM-SR的年度预算为1,250,002美元，但CCSG请求为105,312美元。因此，ATM-SR利用了广泛的机构支持，仅从CCSG资金中寻求8％。这 ATM-SR专注于三个主要科学目的：（1）产生转基因和敲除小鼠，（2）提供临床前肿瘤学模型服务，（3）提供组织病理学服务。