Core 3: Bioinformatics and Biostatistics Core

核心3：生物信息学和生物统计学核心

• 批准号: 10411671
• 负责人: Yuan Liu
• 金额: $ 26.22万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10411671
• 关键词: Address; Area; Basic Science; Bioinformatics; Biological; Biological Process; Biometry; Biostatistics Core; Cells; Clinical; Clinical Research; Clinical Trials; Clinical Trials Design; Collaborations; Communication; Critical Thinking; Custom; Data; Data Analyses; Data Management Resources; Development; Elements; Ensure; Experimental Designs; Fostering; Genes; Goals; Immunity; Immunotherapy; Information Systems; Infrastructure; Lung; Lung Adenocarcinoma; Malignant neoplasm of lung; Manuscripts; Medical; Medical Informatics; Methodology; Molecular; Molecular Immunology; Monitor; Mutate; PTK2 gene; Pathway interactions; Patients; Phase; Preparation; Program Research Project Grants; Protocols documentation; Reporting; Reproducibility; Research; Research Activity; Research Personnel; Research Project Grants; Resistance; Resources; Role; STK11 gene; Sampling; Secure; Statistical Data Interpretation; Systems Biology; Therapeutic; Work; anti-cancer; base; cancer information system; computational platform; data acquisition; data exchange; data integrity; data management; data sharing; design; experience; innovation; laboratory experiment; lung cancer cell; member; molecular pathology; multidisciplinary; next generation; novel; programs; prospective; resistance mechanism; shared database; success; translational study; tumorigenesis

SUMMARY The Emory Lung Cancer P01 application aims to decipher the underlying mechanisms of immunotherapy resistance of LKB1-mut lung cancer and to seek possible therapeutic solutions with three interconnected projects to address this urgent unmet medical need. The function of the Bioinformatics and Biostatistics Core (Core 3) is to provide robust and transparent analytic strategies, sophisticated and integrated data analysis and management platforms, and state-of-the-art methodologies to maximize the success of the overall program through guiding and fostering data-driven interactions and collaborations. To support this goal, our Core 3 team of investigators has complementary expertise and extensive experience in biostatistics, bioinformatics, and medical informatics and data management that is critical for rigorous experimental design and streamlined data analysis, interpretation, sharing and management for basic mechanism-driven examination and clinical studies. Specifically, we will (i) provide comprehensive biostatistical expertise and resources in support to Lung Cancer P01 projects, including novel clinical trial design; (ii) provide a new integrative computational platform to support the elucidation of the molecular basis for GDH1 (Project 1), IAP/STING (Project 2), and FAK (Project 3)- dependent tumorigenesis in LKB1-deficient lung cancer with project leaders; and (iii) develop and maintain a centralized data acquisition and management system that is customized explicitly for this P01. Core 3 serves as a focal point of the P01 to ensure data integrity, scientific rigor, and sharing; and to foster collaborations between projects based on integrated analysis of mechanistic and clinical results and close interactions with each project and Core 1 and Core 2 through a shared database. Serving as a critical component of the P01 Program, Core 3 will be critical to further safeguard and elevate the entire research quality in this P01 to support the development of the next generation of effective anticancer immunity-based therapeutic strategies for patients with LKB1 mutated lung cancer.

概括 埃默里肺癌 P01 申请旨在破译免疫治疗的潜在机制 LKB1-mut 肺癌的耐药性，并通过三个相互关联的项目寻求可能的治疗解决方案 解决这一未得到满足的紧急医疗需求。生物信息学和生物统计学核心（Core 3）是提供稳健和透明的分析策略、复杂和集成的数据分析和 管理平台和最先进的方法，以最大限度地提高整个计划的成功 通过指导和促进数据驱动的互动与协作。为了支持这一目标，我们的 Core 3 团队 的研究人员在生物统计学、生物信息学和 医学信息学和数据管理对于严格的实验设计和简化的数据至关重要 基础机制驱动检查和临床研究的分析、解释、共享和管理。 具体来说，我们将 (i) 提供全面的生物统计专业知识和资源来支持肺癌 P01项目，包括新颖的临床试验设计； (ii) 提供新的综合计算平台来支持 阐明 GDH1（项目 1）、IAP/STING（项目 2）和 FAK（项目 3）的分子基础 - 与项目负责人一起研究 LKB1 缺陷型肺癌的依赖性肿瘤发生； (iii) 开发并维护 专门为此 P01 定制的集中式数据采集和管理系统。核心 3 作为 P01 的焦点，确保数据完整性、科学严谨性和共享；并促进之间的合作 基于机械和临床结果的综合分析以及与每个项目的密切互动的项目 Core 1 和 Core 2 通过共享数据库。作为 P01 计划的重要组成部分，核心 3对于进一步保障和提升本P01的整体研究质量以支持发展至关重要 针对 LKB1 患者的下一代有效的基于抗癌免疫的治疗策略 突变肺癌。