Circuit interactions within the OCDnet

项目摘要 项目1 强迫症(OCD)的病理生理学与多种疾病的回路功能障碍有关 皮质区域(嘴前扣带回(RACC)、背侧扣带回(DACC)、前额叶腹外侧区 (VLPFC)、眶前皮质(OFC)、脑岛)和嘴侧纹状体，一起整合了相关的信息 行为上的僵化，导致持续的回避。这些结构在OCD中被称为‘节点’ 网络(OCDnet)。从解剖学上讲，这些节点广泛地相互连接，相互影响。 这创造了一个复杂的网络，它奠定了优化积极成果所需的灵活性。人类 成像研究表明，“枢纽”，定义为具有异常高和多样化的连接性的地区，存在于 分布式网络。这些枢纽被认为对整合和分发信息很重要。然而， 集线器通过成像来定义，该成像不能区分将整合信息的区域的输入， 以及将分发信息的区域的输出。P1结合了定量解剖学方法和状态- 在NHP和人类中进行最先进的成像，以表征OCDnet互连的复杂性 通过识别纹状体中的中枢位置、它们的路径和投影区。我们假设：1.在 根据其连通性配置文件，每个节点都有特定的区域，可归类为综合区域 中枢(i-中枢)、分布中枢(d-Hub)或两者兼而有之(中心中枢-c-中枢)；2.中枢向纹状体投射的区域 与非枢纽投影区相比，更具扩张性。目标1和目标2使用示踪剂实验来定位枢纽， 勾画出它们的组成，并在ALIC、CC和CB中定位它们的纤维。A3将使用这些解剖数据， 结合最先进的结构(DMRI)和功能成像(RsMRI)在NHP和人类中确定 中枢的位置，以及它们在人脑的ALIC、CC和CB中的纤维通路。

Project Summary Project 1 The pathophysiology of obsessive compulsive disorder (OCD) is associated with circuit dysfunction in several cortical regions, (rostral anterior cingulate cortex (rACC), dorsal ACC (dACC), ventrolateral prefrontal cortex (vlPFC), orbitofrontal cortex (OFC), insula), and the rostral striatum, that, together integrate information related to behavioral inflexibility, resulting in persistent avoidance. These structures are referred as ‘nodes’ in the OCD network (OCDnet). Anatomically these nodes are interconnected extensively to mutually influence each other. This creates the complex network that underlies the required flexibility for optimizing positive outcomes. Human imaging studies show that ‘hubs’, defined as regions with unusually high and diverse connectivity, exist within distributed networks. These hubs are considered important for integrating and distributing information. However, hubs are defined by imaging which cannot distinguish between inputs to a region that would integrate information, and outputs of a region that would distribute information. P1 combines quantitative anatomic methods with state- of-the-art imaging in both NHP and humans to characterize the complexity of the interconnections of the OCDnet by identifying hub locations, their pathways, and projection zones in the striatum. We hypothesize: 1. that within each node there are specific regions, based on their connectivity profiles, that can be classified as integrative hubs (i-hubs), distributive hubs (d-hubs), or both (central hubs-c-hubs); 2. hub projection zones to the striatum are more expansive compared to nonhub projection zones. Aims 1 & 2 use tracer experiments to locate hubs, delineate their composition, and locate their fibers within the ALIC, CC, and CB. A3 will use this anatomic data, coupled with state-of-the-art structural (dMRI) and functional imaging (rsMRI) in NHPs and humans to determine the location of hubs, their fiber pathways in the ALIC, CC and CB in the human brain.