Circuit interactions within the OCDnet

项目摘要 项目1 强迫症（OCD）的病理生理学与几种神经回路功能障碍有关。 皮质区，（喙前扣带皮层（rACC），背侧ACC（dACC），腹外侧前额叶皮层 大脑皮层（vlPFC）、眶额皮质（OFC）和吻侧纹状体，它们一起整合与大脑皮层（vlPFC）、眶额皮质（OFC）和吻侧纹状体相关的信息。 行为上的不适应导致持续的回避这些结构在强迫症中被称为“节点” 网络（OCDnet）。在解剖学上，这些节点广泛地相互连接以相互影响。 这就形成了一个复杂的网络，它是优化积极成果所需的灵活性的基础。人类 成像研究表明，“枢纽”，定义为具有异常高和多样的连接区域，存在于 分布式网络。这些中心被认为对整合和分发信息很重要。然而，在这方面， 集线器通过不能区分对将集成信息的区域的输入的成像来定义， 以及一个区域的输出来传播信息。P1结合了定量解剖学方法和状态- NHP和人类最先进的成像，以表征OCDnet互连的复杂性 通过识别中枢位置，它们的通路，以及纹状体中的投射区。我们假设：1.之内 每个节点都有特定的区域，根据它们的连通性配置文件，可以将其分类为综合区域。 集线器（i-集线器）、分布式集线器（d-集线器）或两者（中央集线器-c-集线器）; 2.中枢投射区到纹状体 与非中心投影区相比，更广泛。目标1和2使用示踪实验来定位枢纽， 描绘它们的组成，并在ALIC、CC和CB内定位它们的纤维。A3将使用这些解剖数据， 结合NHP和人类最先进的结构成像（dMRI）和功能成像（rsMRI）， 中枢的位置，它们在人脑中的ALIC、CC和CB中的纤维通路。

Project Summary Project 1 The pathophysiology of obsessive compulsive disorder (OCD) is associated with circuit dysfunction in several cortical regions, (rostral anterior cingulate cortex (rACC), dorsal ACC (dACC), ventrolateral prefrontal cortex (vlPFC), orbitofrontal cortex (OFC), insula), and the rostral striatum, that, together integrate information related to behavioral inflexibility, resulting in persistent avoidance. These structures are referred as ‘nodes’ in the OCD network (OCDnet). Anatomically these nodes are interconnected extensively to mutually influence each other. This creates the complex network that underlies the required flexibility for optimizing positive outcomes. Human imaging studies show that ‘hubs’, defined as regions with unusually high and diverse connectivity, exist within distributed networks. These hubs are considered important for integrating and distributing information. However, hubs are defined by imaging which cannot distinguish between inputs to a region that would integrate information, and outputs of a region that would distribute information. P1 combines quantitative anatomic methods with state- of-the-art imaging in both NHP and humans to characterize the complexity of the interconnections of the OCDnet by identifying hub locations, their pathways, and projection zones in the striatum. We hypothesize: 1. that within each node there are specific regions, based on their connectivity profiles, that can be classified as integrative hubs (i-hubs), distributive hubs (d-hubs), or both (central hubs-c-hubs); 2. hub projection zones to the striatum are more expansive compared to nonhub projection zones. Aims 1 & 2 use tracer experiments to locate hubs, delineate their composition, and locate their fibers within the ALIC, CC, and CB. A3 will use this anatomic data, coupled with state-of-the-art structural (dMRI) and functional imaging (rsMRI) in NHPs and humans to determine the location of hubs, their fiber pathways in the ALIC, CC and CB in the human brain.