Neurocircuitry of OCD: Effects of Modulation

强迫症的神经回路：调节的影响

• 批准号: 8856141
• 负责人: Suzanne N Haber
• 金额: $ 200万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8856141
• 关键词: Affect; Aftercare; Amygdaloid structure; Anatomy; Animals; Anterior; Area; Behavior; Biological Neural Networks; Chronic; Cognitive; Corpus striatum structure; Data; Decision Making; Devices; Diffusion Magnetic Resonance Imaging; Disease; Dorsal; Emotional; Emotions; Equilibrium; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Human; Individual; Link; Magnetic Resonance Imaging; Mediating; Mental Depression; Mental disorders; Methods; Neurons; Obsessive-Compulsive Disorder; Pathway interactions; Patients; Pattern; Population; Positioning Attribute; Post-Traumatic Stress Disorders; Prefrontal Cortex; Process; Rest; Structure; System; Testing; Therapeutic; Transcranial magnetic stimulation; Travel; Ulysses Contracts; Variant; Work; World Health Organization; addiction; anatomical tracing; base; cingulate cortex; cingulotomy; cognitive control; design; improved; individualized medicine; neuroregulation; new therapeutic target; nonhuman primate; novel; optogenetics; public health relevance; research study; response; therapeutic target; tool

 DESCRIPTION (provided by applicant): The overall goal of this Center is to further our understanding of the neural network central to obsessive compulsive disorder (OCD) and the abnormalities within that network that are associated with the disease. Specifically, we will use a multimodal, network approach to: 1. localize specific regions and the pathways that connect them that are altered in the disease; 2. determine the effects of neuromodulation on the connectivity of the circuit(s); and 3. use these data to develop a non-invasive approach for individualized treatment. To understand the network underlying OCD, we use a multidimensional approach combining anatomy (structural analysis at the neuronal level) with global patterns of activity and connectivity (diffusion and functional MRI) to characterize the critical connections that underlie functional abnormalities in the OCD circuit, and the network changes following neuromodulation. Our central hypothesis is that OCD is characterized by hyperconnectivity between the amygdala/ventromedial prefrontal cortex and dorsal anterior cingulate (dACC) and orbitofrontal cortex (OFC), and decreased connectivity between dACC/OFC and dorsolateral and ventrolateral prefrontal cortex. This change in balance between emotion and cognitive control systems results in a heightened activity state in the dorsal striatum. We also posit that the structural basis for abnormalities in activity center aroun specific cortical regions (or nodes) that connect emotion-associated regions with those involved in cognitive control. Furthermore, we predict variability in the position of these nodes across individuals. Finally, we hypothesize that modulation of the circuit will return connectivity profils to relatively normal levels. The studies will provide a translational link to probe novel therapeutc targets. As this network has been linked to a wide range of psychiatric disorders including, depression, post-traumatic stress disorder, addictions, the resulting data will have implications that extend well beyond OCD.

 描述（由适用提供）：该中心的总体目标是进一步了解强迫症（OCD）和该网络中与该疾病相关的异常的理解。具体来说，我们将使用 多模式的网络方法：1。定位特定区域及其连接疾病改变的途径； 2。确定神经调节对电路连通性的影响；和3。使用这些数据开发一种非侵入性方法来进行个性化治疗。为了了解强迫症的潜在网络，我们使用一种多维方法，该方法将解剖学（神经元水平的结构分析）与全球活动和连通性模式（扩散和功能性MRI）相结合，以表征OCD电路中功能异常的关键连接以及神经调节后网络变化的关键连接。我们的中心假设是，强迫症的特征是杏仁核/腹侧前额叶皮层和背前扣带回（DACC）和甲状腺皮质（OFC）之间的过度连接性，并改善了DACC/OFC/OFC和甲状腺酸和腹膜和腹膜前胸腔前叶状性。情绪和认知控制系统之间的平衡变化导致背纹状体的活动状态增强。我们还认为，活动中异常的结构基础是将情绪相关区域与参与认知控制的特定皮质区域（或节点）围绕的特定皮质区域（或节点）。此外，我们可以预测这些节点在个体之间的位置的可变性。最后，我们假设电路的调制将返回连通性概况到相对正常的水平。这些研究将为探测新型治疗靶标提供转化联系。由于该网络已与多种精神疾病有关，包括抑郁症，创伤后应激障碍，成瘾，因此所产生的数据将具有远远超出OCD的含义。