Research Education Core

研究教育部分项目摘要/摘要 在阿尔茨海默病和相关痴呆（ADRD）中，一个快速发展的领域已经获得了 对许多可能的互补疾病机制的全面见解，揭示了相关的 遗传和环境因素，神经病理学异常的连续体，代表 疾病的最早阶段和一系列临床表现。然而，在知识方面仍然存在巨大差距， 关于疾病建模，遗传学和病理生理学，当然还有治疗。哥伦比亚大学 (CU)研究教育部分（REC）将是一个全面的培训计划， 有效地培养下一代ADRD领导者，以便在ADRD研究中取得突破 通过既有的和新的研究方法。CU REC培训计划将为以下人员提供培训 研究人员包括两个不同的群体：a）那些通过传统培训进入ADRD研究的人 路径（例如，神经学家，神经心理学家，基础和翻译研究人员）， 在短期内对该领域做出贡献，以及B）来自非传统途径的研究人员（例如， 生物信息学/数据科学、工程、公共卫生和相关卫生），他们已经证明了独特的， 成熟的研究技能，如果重新定位于ADRD，可能会对ADRD产生新的重要影响 research. REC培训计划增强了CU ADRC的主要目标： 正在进行的研究工作，在ADRD在CU，并支持ADRD研究人员的多样化群体，使这些 发现。CU REC培训计划提供了一个结构化的框架，有前途的初级研究人员， 通过我们庞大的机构研究基础设施确定，可以利用建立成功的职业生涯， ADRD。通过与结构化研究项目挂钩的持续多学科导师制，有效支持 初级研究人员可以独立开发假设，批判性地评价相关文献，并构建一个 一个经过适当磨练的研究问题的复杂方法。培训将包括个性化的 为每个受训者及其当前和未来的职业发展阶段量身定制的发展计划， 基础的理解，从它启动一个成功的研究生涯。该计划将建立在 CU ADRC和神经病学系的长期实践，后者具有最高的轨道 学员成为世界上任何机构的学术神经学家的记录。总而言之， REC培训计划的目的是通过以下方式培养下一代ADRD研究人员：1）确定3-5 初级研究人员，有希望为ADRD领域做出重大贡献（目标1）; 2）绘制 来自ADRD领域以及传统ADRD研究途径之外的领域的学员，特别是那些 3）为所有学员提供个性化的发展计划， 包括多学科指导，在广泛的内部研究和教育的经验， 计划在CU，以及一个综合计划，以了解如何获得和实现持续的赠款支持 迈向下一个职业阶段（目标3）。

RESEARCH EDUCATION COMPONENT PROJECT SUMMARY/ABSTRACT In Alzheimer’s Disease and Related Dementias (ADRD), a rapidly developing field has gained comprehensive insights into a host of likely complementary disease mechanisms, shedding light on relevant genetic and environmental factors, a continuum of neuropathological abnormalities, biomarkers that represent the earliest stages of disease, and an array of clinical presentations. Yet, large gaps in knowledge remain regarding disease modeling, genetics and pathophysiology, and of course, treatment. The Columbia University (CU) Research Education Component (REC) will be a comprehensive training program to effectively and efficiently develop the next generation of ADRD leaders poised to make breakthroughs in ADRD research through both established and novel research methods. The CU REC Training Program will provide training for researchers comprising two distinct groups: a) those entering ADRD research through conventional training paths (e.g., neurologists, neuropsychologists, basic and translational researchers) with great promise to contribute to the field in the near term, and b) researchers from non-conventional paths (e.g., bioinformatics/data science, engineering, public health, and allied health) who have demonstrated unique and accomplished research skills, which if reoriented to ADRD, could make novel and important impacts on ADRD research. The REC Training Program enhances primary aims of the CU ADRC: to enable and enhance ongoing research efforts in ADRD at CU, and support a diverse group of ADRD researchers making these discoveries. The CU REC Training Program provides a structured framework that promising junior researchers, identified through our vast institutional research infrastructure, can leverage to establish successful careers in ADRD. With ongoing, multidisciplinary mentorship tied to a structured research project, effectively supported junior researchers can independently develop hypotheses, critically appraise related literature, and frame a sophisticated approach to an appropriately honed research question. Training will include an individualized development plan tailored to each trainee and his or her current and future career steps, enabling a foundational understanding from which to launch a successful research career. This program will build upon the longstanding practices of the CU ADRC and Department of Neurology, the latter having the highest track record of trainees becoming academic neurologists of any institution in the world. In sum, the overarching goal of the REC Training Program is to develop the next generation of ADRD researchers by: 1) identifying 3-5 junior investigators with promise for making significant contributions to the field of ADRD (Aim 1); 2) drawing trainees from ADRD fields as well as fields beyond traditional pathways to ADRD research, especially those from diverse backgrounds (Aim 2); and 3) providing all trainees with an individualized development plan that includes multidisciplinary mentorship, experiences within the expansive internal research and education program at CU, and an integrated plan to understand how to access and achieve sustained grant support towards next career steps (Aim 3).