UCSF Career Development Program in Cardiopulmonary, Hematologic, and Immunologic Comorbidities of HIV (CHIC)

加州大学旧金山分校艾滋病心肺、血液和免疫合并症职业发展计划 (CHIC)

• 批准号: 10413803
• 负责人: LAURENCE HUANG
• 金额: $ 41.98万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10413803
• 关键词: Academic Training; Acquired Immunodeficiency Syndrome; Blood; California; Cardiology; Cardiopulmonary; Cardiovascular Diseases; Cardiovascular system; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communicable Diseases; Critical Care; Doctor of Philosophy; Faculty; Foundations; Funding; Goals; Grant; HIV; Heart Diseases; Hematological Disease; Hematology; Immunologics; Institutes; International; K-12 Faculty; Leadership; Lung; Lung diseases; Medicine; Mentored Clinical Scientist Development Program; Mentors; NCI Scholars Program; Peer Review; Program Development; Publications; Pulmonary Heart Disease; Records; Research; Research Institute; Research Methodology; Research Personnel; Resources; SECTM1 gene; San Francisco; Talents; Training; Translational Research; Universities; University resources; career; career development; cohort; comorbidity; experience; implementation research; innovation; interest; medical schools; next generation; programs; systems research

PROJECT SUMMARY/ABSTRACT We propose to establish an innovative, interdisciplinary K12 Career Development Program in Cardiopulmonary, Hematologic, and Immunologic Comorbidities of HIV (CHIC) at the University of California San Francisco (UCSF). The primary focus of this program will be clinical and translational (C&T) research in HIV-associated cardiopulmonary diseases both in the US and internationally but program faculty possess the content expertise to accommodate meritorious scholars interested in C&T research in HIV-associated hematologic diseases and HIV cure research. This K12 program will train exceptional MD, MD/PhD, and PhD scholars dedicated to careers in C&T research, leveraging the substantial academic training, career development, and research resources of UCSF including the UCSF Clinical & Translational Science Institute (CTSI), the UCSF AIDS Research Institute (ARI), the UCSF-Gladstone Center for AIDS Research (CFAR), the UCSF Cardiovascular Research Institute (CVRI), and the Blood Systems Research Institute (BSRI). This K12 will bring together 35 accomplished, experienced, and expert faculty researchers under a single program that will strengthen existing research collaborations and catalyze new ones. Program faculty are primarily from the following 3 Divisions: Pulmonary and Critical Care Medicine; Cardiology; and HIV, Infectious Diseases, and Global Medicine within the Department of Medicine in the School of Medicine. Faculty have demonstrated records of independent research funding, successful research collaborations, and peer-reviewed publications. In keeping with UCSF's rich tradition of collaboration, K12 faculty have existing research collaborations and co-authored publications with other program faculty, providing scholars with a vast network of mentors and co-mentors. Program faculty have a wealth of HIV clinical cohorts both in San Francisco and internationally that will serve as the foundation for the mentored C&T research experience of K12 scholars. K12 faculty are experienced and successful mentors. Faculty are also leaders of the UCSF CTSI Masters in Clinical Research (MAS) Program and KL2 K Scholars Program that will provide much of the formal didactic training in C&T research methods for the K12 scholars. Finally, K12 faculty are also Program Directors of K12 Programs in Omics of Lung Disease and Implementation Research in Heart and Lung Diseases at UCSF, Program Directors of T32 Training Grants in Lung Disease, Cardiovascular Disease, and HIV Translational Research, and Division Chiefs of Cardiology, HIV, Infectious Diseases, and Global Medicine and Experimental Medicine Divisions, providing unparalleled leadership, experience and expertise in academic training and career development as well as access to a deep and replenishing pool of exceptionally-talented scholars. Our main goal is to produce the `next generation' of researchers in HIV-associated heart, lung and blood diseases.

项目总结/摘要 我们建议建立一个创新的，跨学科的K12职业发展计划， 加州大学旧金山分校弗朗西斯科的HIV血液学和免疫学共病（CHIC） （UCSF）。该计划的主要重点将是艾滋病毒相关疾病的临床和转化（C & T）研究。 心肺疾病在美国和国际上，但程序教师拥有内容的专业知识 以容纳有兴趣在C & T在艾滋病毒相关血液病研究的优秀学者， 艾滋病治疗研究。这个K12计划将培养杰出的MD，MD/PhD和博士学者致力于职业生涯 在C & T研究中，利用大量的学术培训，职业发展和研究资源， UCSF包括UCSF临床与转化科学研究所（CTSI），UCSF艾滋病研究所 (ARI)，UCSF格莱斯顿艾滋病研究中心（CFAR），UCSF心血管研究所 （CVRI）和血液系统研究所（BSRI）。这K12将汇集35完成， 经验丰富，专家教员研究人员在一个单一的计划，将加强现有的研究 合作并促进新的合作。项目教师主要来自以下3个部门：肺 和重症监护医学;心脏病学;和艾滋病毒，传染病和全球医学 医学院医学系。教师们已经证明了独立研究的记录 资金，成功的研究合作和同行评审的出版物。加州大学旧金山分校的富人 合作的传统，K12教师有现有的研究合作和共同撰写的出版物， 其他计划的教师，为学者提供了导师和共同导师的庞大网络。课程教师有 在旧金山弗朗西斯科和国际上， 指导K12学者的C & T研究经验。K12教师是经验丰富和成功的导师。 教师也是UCSF CTSI临床研究硕士（MAS）计划和KL2 K学者的领导者 该计划将为K12学者提供C & T研究方法的正式教学培训。 最后，K12教师也是K12计划在肺部疾病组学和实施的项目总监 加州大学旧金山分校心肺疾病研究，T32培训赠款项目主任， 心血管疾病和艾滋病毒转化研究，以及心脏病学，艾滋病毒，传染病 疾病，全球医学和实验医学部门，提供无与伦比的领导， 在学术培训和职业发展方面的经验和专业知识，以及获得深入和 补充一批才华横溢的学者我们的主要目标是生产"下一代"， 艾滋病相关心脏、肺和血液疾病的研究人员。

项目成果

The Breadth of the Neutralizing Antibody Response to Original SARS-CoV-2 Infection is Linked to the Presence of Long COVID Symptoms.

中和抗体对原始 SARS-CoV-2 感染的反应范围与长期新冠肺炎症状的存在有关。

• DOI: 10.1101/2023.03.30.23287923
• 发表时间: 2023
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Buck,AmandaM;Deitchman,AmeliaN;Takahashi,Saki;Lu,Scott;Goldberg,SarahA;Hoh,Rebecca;Williams,MeghannC;Kerbleski,Marian;Deveau,Tyler-Marie;Munter,SadieE;Lombardo,James;Wrin,Terri;Petropoulos,ChristosJ;Durstenfeld,MatthewS

Association of Right Ventricular Dilation on Echocardiogram With In-Hospital Mortality Among Patients Hospitalized With COVID-19 Compared With Bacterial Pneumonia.

• DOI: 10.1016/j.echo.2022.12.019
• 发表时间: 2023-05
• 期刊: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

Coronary Assessment in Heart Failure within a Safety-Net Setting: Disparities and Outcomes.

安全网环境下心力衰竭的冠状动脉评估：差异和结果。

• DOI: 10.1101/2023.07.06.23292331
• 发表时间: 2023
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Durstenfeld,MatthewS;Thakkar,Anjali;Ma,Yifei;Zier,LucasS;Davis,JonathanD;Hsue,PriscillaY
• 通讯作者: Hsue,PriscillaY

Lung Function in Women With and Without Human Immunodeficiency Virus.

• DOI: 10.1093/cid/ciac391
• 发表时间: 2023-02-08
• 期刊: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America