Lung Function in Women With and Without Human Immunodeficiency Virus.
Lung Function in Women With and Without Human Immunodeficiency Virus.
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DOI：
10.1093/cid/ciac391
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发表时间：
2023-02-08
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
先前的研究发现，人类免疫缺陷病毒（HIV）感染与肺功能受损和慢性肺病风险增加有关，但很少有大量妇女参与。在这项研究中，我们调查了艾滋病毒感染是否与女性肺功能的差异有关。这是一项对妇女跨部门艾滋病毒研究参与者的横断面分析，该研究是一项种族和民族多样化的多中心队列研究，研究对象是感染和不感染艾滋病毒的妇女。2018-2019年，邀请了9个临床中心的参与者进行肺量测定。还在选定的部位测量了一氧化碳单次呼吸弥散量（DLCO）。主要结局为支气管扩张剂后1秒用力呼气量（FEV 1）和DLCO。在调整混杂暴露后，采用多变量回归模型分析HIV感染与肺功能结局的相关性。1489名女性（1062名感染艾滋病毒，427名未感染艾滋病毒）的FEV 1测量值和671名女性（463名感染艾滋病毒，208名未感染艾滋病毒）的DLCO测量值符合质量和重现性标准。感染和未感染HIV的女性之间FEV 1无显著差异。HIV感染女性的DLCO测量值较低（校正差异为-0.73 mL/min/mm Hg; 95%置信区间为-1.33至-0.14）。在HIV感染女性中，较低的最低CD 4+细胞计数和丙型肝炎病毒感染与较低的DLCO测量值相关。艾滋病毒与女性呼吸气体交换受损有关。在感染艾滋病毒的女性中，较低的CD 4+细胞计数和丙型肝炎感染与呼吸气体交换减少有关。在这个多中心队列中，有和没有人类免疫缺陷病毒（HIV）的妇女，HIV感染与呼吸气体交换受损。在HIV感染者中，较低的最低CD 4+细胞计数和丙型肝炎感染也与呼吸气体交换减少有关。
Prior studies have found that human immunodeficiency virus (HIV) infection is associated with impaired lung function and increased risk of chronic lung disease, but few have included large numbers of women. In this study, we investigate whether HIV infection is associated with differences in lung function in women. This was a cross-sectional analysis of participants in the Women’s Interagency HIV Study, a racially and ethnically diverse multicenter cohort of women with and without HIV. In 2018–2019, participants at 9 clinical sites were invited to perform spirometry. Single-breath diffusing capacity for carbon monoxide (DLCO) was also measured at selected sites. The primary outcomes were the post-bronchodilator forced expiratory volume in 1 second (FEV1) and DLCO. Multivariable regression modeling was used to analyze the association of HIV infection and lung function outcomes after adjustment for confounding exposures. FEV1 measurements from 1489 women (1062 with HIV, 427 without HIV) and DLCO measurements from 671 women (463 with HIV, 208 without HIV) met standards for quality and reproducibility. There was no significant difference in FEV1 between women with and without HIV. Women with HIV had lower DLCO measurements (adjusted difference, –0.73 mL/min/mm Hg; 95% confidence interval, −1.33 to −.14). Among women with HIV, lower nadir CD4 + cell counts and hepatitis C virus infection were associated with lower DLCO measurements. HIV was associated with impaired respiratory gas exchange in women. Among women with HIV, lower nadir CD4 + cell counts and hepatitis C infection were associated with decreased respiratory gas exchange. In this multicenter cohort of women with and without human immunodeficiency virus (HIV), HIV infection was associated with impaired respiratory gas exchange. Among participants with HIV, lower nadir CD4 + cell counts and hepatitis C infection were also associated with decreased respiratory gas exchange.
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围绝经期时，女性吸烟者的慢性阻塞性肺部疾病的风险增加了：一种系统的综述和荟萃分析。
影响因子：
5.8
作者：
Gan, WQ;Man, SP;Postma, DS;Camp, P;Sin, DD
通讯作者：
Sin, DD
DOI：
10.1097/qad.0000000000002846
发表时间：
2021-06-01
期刊：
AIDS (London, England)
影响因子：
--
作者：
Jan AK;Moore JV;Wang RJ;Mcging M;Farr CK;Moisi D;Hartman-Filson M;Kerruish R;Jeon D;Lewis E;Crothers K;Lederman MM;Hunt PW;Huang L
通讯作者：
Huang L
影响因子：
9.6
作者：
Crothers, Kristina;Butt, Adeel A.;Justice, Amy C.
通讯作者：
Justice, Amy C.
影响因子：
105.7
作者：
FLETCHER, C;PETO, R
通讯作者：
PETO, R
影响因子：
4.5
作者：
Erturk, A.;Tokgonul, A. N.;Bozkaya, H.
通讯作者：
Bozkaya, H.