Integrating data streams with multi-scale modeling to guide norovirus vaccine decision-making
将数据流与多尺度建模相结合,指导诺如病毒疫苗决策
基本信息
- 批准号:10413200
- 负责人:
- 金额:$ 34.03万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-06-01 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAgeAnimal ModelBiologicalCell Culture SystemCessation of lifeDataData SetData SourcesDecision MakingDependenceDevelopmentDiarrheaDiseaseDisease OutbreaksEpidemiologyEvolutionFaceFrequenciesGenotypeGoalsHandHealth PolicyHealth StatusHumanImmunityIndividualInfectionInfection ControlMathematicsMeasuresMethodsModelingNorovirusPhylogenetic AnalysisPoliciesPopulationPopulation GeneticsPublic HealthRouteSamplingSeriesStatistical ModelsStructureTimeUnited StatesUpdateVaccinationVaccine DesignVaccinesViralVirusVirus Sheddinganalytical methodauthoritydata streamsdesignfield studyhuman dataimplementation strategyinnovationinsightmathematical modelmodels and simulationmulti-scale modelingmultiple data sourcesnational surveillancetooltransmission processuser-friendlyvaccination strategyvaccine developmentvaccine distributionvaccine formulationvaccine strategyvirus geneticsvolunteer
项目摘要
PROJECT SUMMARY
Noroviruses cause over 20 million diarrhea cases annually in the United States, one-fifth of all diarrhea cases
globally, and over 200,000 deaths worldwide. Norovirus vaccines are currently in development. Our goal is to
develop a comprehensive detailed, user-friendly norovirus transmission and vaccination simulator that will help
guide and inform norovirus vaccine design and implementation.
To achieve this goal, a number of specific insights and parameter estimates are required, such as: At what rate
does immunity to norovirus wane in individuals? How does prior infection (or vaccination) affect the course of
illness and the duration/quantity of viral shedding? What is the degree of cross-protecting immunity at the
genogroup, genotype and strain-level? With such results in hand, we can answer the following vaccine strategy
questions: What frequency of re-vaccination is required for control? How often will a norovirus vaccine need to
be updated to keep up with viral evolution? What are the population-level health impacts of age-targeted (or
other) vaccination strategies?
To answer these questions, we will integrate detailed data from multiple sources including volunteer infection
studies, national surveillance, and viral sequence datasets. We will fit mathematical and statistical models to
these datasets to answer the questions posed above. Our analyses will provide a thorough understanding of
the epidemiological and evolutionary dynamics of the virus. This information will be used to develop and
implement a detailed norovirus transmission and vaccination simulator. This simulator will be packaged as a
user-friendly application for vaccine designers and policy implementers to analyze and forecast possible
impacts of vaccine formulations and distribution strategies.
项目摘要
在美国,诺如病毒每年导致超过2000万例腹泻病例,占所有腹泻病例的五分之一
全球范围内,超过200,000人死亡。诺如病毒疫苗目前正在开发中。我们的目标是
开发一个全面详细、用户友好的诺如病毒传播和疫苗接种模拟器,
指导并告知诺如病毒疫苗的设计和实施。
为了实现这一目标,需要一些具体的见解和参数估计,例如:
个体对诺如病毒的免疫力是否减弱?既往感染(或疫苗接种)如何影响
疾病和病毒脱落的持续时间/数量?交叉保护免疫力的程度是什么
基因组、基因型和菌株水平?有了这样的结果在手,我们可以回答以下疫苗策略
问题:需要多长时间进行一次复种?诺如病毒疫苗需要多久接种一次
更新以跟上病毒的进化吗针对年龄的(或
疫苗接种策略?
为了回答这些问题,我们将整合包括志愿者感染在内的多个来源的详细数据
研究、国家监测和病毒序列数据集。我们将拟合数学和统计模型,
这些数据集来回答上述问题。我们的分析将提供对以下内容的透彻了解
病毒的流行病学和进化动力学。这些信息将用于开发和
实施详细的诺如病毒传播和疫苗接种模拟程序。该模拟器将打包为
方便疫苗设计者和政策执行者分析和预测可能的
疫苗配方和分配战略的影响。
项目成果
期刊论文数量(29)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Five approaches to the suppression of SARS-CoV-2 without intensive social distancing.
- DOI:10.1098/rspb.2020.3074
- 发表时间:2021-04-28
- 期刊:
- 影响因子:0
- 作者:Drake JM;Dahlin K;Rohani P;Handel A
- 通讯作者:Handel A
Norovirus transmission mitigation strategies during simulated produce harvest and packing.
- DOI:10.1016/j.ijfoodmicro.2021.109365
- 发表时间:2021-11-02
- 期刊:
- 影响因子:5.4
- 作者:Sobolik JS;Newman KL;Jaykus LA;Bihn EA;Leon JS
- 通讯作者:Leon JS
Dynamic network strategies for SARS-CoV-2 control on a cruise ship.
- DOI:10.1016/j.epidem.2021.100488
- 发表时间:2021-12
- 期刊:
- 影响因子:3.8
- 作者:Jenness SM;Willebrand KS;Malik AA;Lopman BA;Omer SB
- 通讯作者:Omer SB
Genetic drift and purifying selection shape within-host influenza A virus populations during natural swine infections.
在自然猪感染期间,遗传漂变和纯化选择塑造了宿主甲型流感病毒种群。
- DOI:10.1101/2023.10.23.563581
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:VanInsberghe,David;McBride,DillonS;DaSilva,Juliana;Stark,ThomasJ;Lau,MaxSY;Shepard,SamuelS;Barnes,JohnR;Bowman,AndrewS;Lowen,AniceC;Koelle,Katia
- 通讯作者:Koelle,Katia
Controlling risk of SARS-CoV-2 infection in essential workers of enclosed food manufacturing facilities.
控制封闭食品生产设施的重要工作人员感染 SARS-CoV-2 的风险。
- DOI:10.1101/2021.05.14.21257244
- 发表时间:2021
- 期刊:
- 影响因子:0
- 作者:Sobolik,JuliaS;Sajewski,ElizabethT;Jaykus,Lee-Ann;Cooper,DKane;Lopman,BenA;Kraay,AliciaNm;Ryan,PBarry;Leon,JuanS
- 通讯作者:Leon,JuanS
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Benjamin A Lopman其他文献
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{{ truncateString('Benjamin A Lopman', 18)}}的其他基金
COVID-19 - Global Mix / Investigation of COVID-19 Disease Parameters for Transmission Models in Low-Resource Settings
COVID-19 - 全球混合/资源匮乏环境中传播模型的 COVID-19 疾病参数调查
- 批准号:
10367612 - 财政年份:2022
- 资助金额:
$ 34.03万 - 项目类别:
COVID-19 - Global Mix / Investigation of COVID-19 Disease Parameters for Transmission Models in Low-Resource Settings
COVID-19 - 全球混合/资源匮乏环境中传播模型的 COVID-19 疾病参数调查
- 批准号:
10577833 - 财政年份:2022
- 资助金额:
$ 34.03万 - 项目类别:
COVID Global Mix - Global Mix / Investigation of COVID-19 Disease Parameters for Transmission Models in Low-Resource Settings
COVID Global Mix - 全球混合/资源匮乏环境中传播模型的 COVID-19 疾病参数调查
- 批准号:
10863617 - 财政年份:2022
- 资助金额:
$ 34.03万 - 项目类别:
Comprehensive Profiling of Social Mixing Patterns in Resource Poor Countries
资源匮乏国家社会混合模式的综合分析
- 批准号:
10397072 - 财政年份:2019
- 资助金额:
$ 34.03万 - 项目类别:
Comprehensive Profiling of Social Mixing Patterns in Resource Poor Countries
资源匮乏国家社会混合模式的综合分析
- 批准号:
10610730 - 财政年份:2019
- 资助金额:
$ 34.03万 - 项目类别:
Integrating data streams with multi-scale modeling to guide norovirus vaccine decision-making
将数据流与多尺度建模相结合,指导诺如病毒疫苗决策
- 批准号:
10160920 - 财政年份:2018
- 资助金额:
$ 34.03万 - 项目类别:
Modeling ongoing SARS-CoV2 vaccination strategies in light of emerging data on immunity and viral evolution
根据免疫和病毒进化的新数据对正在进行的 SARS-CoV2 疫苗接种策略进行建模
- 批准号:
10398368 - 财政年份:2018
- 资助金额:
$ 34.03万 - 项目类别:
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