Integrating data streams with multi-scale modeling to guide norovirus vaccine decision-making
Integrating data streams with multi-scale modeling to guide norovirus vaccine decision-making
批准号:
10413200
负责人:
Benjamin A Lopman
金额:
$34.03万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-06-01 至 2024-05-31
关键词:
AddressAffectAgeAnimal ModelBiologicalCell Culture SystemCessation of lifeDataData SetData SourcesDecision MakingDependenceDevelopmentDiarrheaDiseaseDisease OutbreaksEpidemiologyEvolutionFaceFrequenciesGenotypeGoalsHandHealth PolicyHealth StatusHumanImmunityIndividualInfectionInfection ControlMathematicsMeasuresMethodsModelingNorovirusPhylogenetic AnalysisPoliciesPopulationPopulation GeneticsPublic HealthRouteSamplingSeriesStatistical ModelsStructureTimeUnited StatesUpdateVaccinationVaccine DesignVaccinesViralVirusVirus Sheddinganalytical methodauthoritydata streamsdesignfield studyhuman dataimplementation strategyinnovationinsightmathematical modelmodels and simulationmulti-scale modelingmultiple data sourcesnational surveillancetooltransmission processuser-friendlyvaccination strategyvaccine developmentvaccine distributionvaccine formulationvaccine strategyvirus geneticsvolunteer
中文摘要
项目总结
英文摘要
PROJECT SUMMARY
Noroviruses cause over 20 million diarrhea cases annually in the United States, one-fifth of all diarrhea cases
globally, and over 200,000 deaths worldwide. Norovirus vaccines are currently in development. Our goal is to
develop a comprehensive detailed, user-friendly norovirus transmission and vaccination simulator that will help
guide and inform norovirus vaccine design and implementation.
To achieve this goal, a number of specific insights and parameter estimates are required, such as: At what rate
does immunity to norovirus wane in individuals? How does prior infection (or vaccination) affect the course of
illness and the duration/quantity of viral shedding? What is the degree of cross-protecting immunity at the
genogroup, genotype and strain-level? With such results in hand, we can answer the following vaccine strategy
questions: What frequency of re-vaccination is required for control? How often will a norovirus vaccine need to
be updated to keep up with viral evolution? What are the population-level health impacts of age-targeted (or
other) vaccination strategies?
To answer these questions, we will integrate detailed data from multiple sources including volunteer infection
studies, national surveillance, and viral sequence datasets. We will fit mathematical and statistical models to
these datasets to answer the questions posed above. Our analyses will provide a thorough understanding of
the epidemiological and evolutionary dynamics of the virus. This information will be used to develop and
implement a detailed norovirus transmission and vaccination simulator. This simulator will be packaged as a
user-friendly application for vaccine designers and policy implementers to analyze and forecast possible
impacts of vaccine formulations and distribution strategies.
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DOI:
10.1098/rspb.2020.3074
发表时间:
2021-04-28
期刊:
Proceedings. Biological sciences
影响因子:
--
作者:
[Drake JM, Dahlin K, Rohani P, Handel A]
通讯作者:
Handel A
DOI:
10.1016/j.ijfoodmicro.2021.109365
发表时间:
2021-11-02
期刊:
International journal of food microbiology
影响因子:
5.4
作者:
[Sobolik JS, Newman KL, Jaykus LA, Bihn EA, Leon JS]
通讯作者:
Leon JS
DOI:
10.1016/j.epidem.2021.100488
发表时间:
2021-12
期刊:
Epidemics
影响因子:
3.8
作者:
[Jenness SM, Willebrand KS, Malik AA, Lopman BA, Omer SB]
通讯作者:
Omer SB
Genetic drift and purifying selection shape within-host influenza A virus populations during natural swine infections.
在自然猪感染期间,遗传漂变和纯化选择塑造了宿主甲型流感病毒种群。
DOI:
10.1101/2023.10.23.563581
发表时间:
2023
期刊:
bioRxiv : the preprint server for biology
影响因子:
--
作者:
[VanInsberghe,David, McBride,DillonS, DaSilva,Juliana, Stark,ThomasJ, Lau,MaxSY, Shepard,SamuelS, Barnes,JohnR, Bowman,AndrewS, Lowen,AniceC, Koelle,Katia]
通讯作者:
Koelle,Katia
Controlling risk of SARS-CoV-2 infection in essential workers of enclosed food manufacturing facilities.
控制封闭食品生产设施的重要工作人员感染 SARS-CoV-2 的风险。
DOI:
10.1101/2021.05.14.21257244
发表时间:
2021
期刊:
medRxiv : the preprint server for health sciences
影响因子:
--
作者:
[Sobolik,JuliaS, Sajewski,ElizabethT, Jaykus,Lee-Ann, Cooper,DKane, Lopman,BenA, Kraay,AliciaNm, Ryan,PBarry, Leon,JuanS]
通讯作者:
Leon,JuanS
共 14 条
COVID-19 - Global Mix / Investigation of COVID-19 Disease Parameters for Transmission Models in Low-Resource Settings
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批准号:10367612
-
项目类别:
-
资助金额:$78.58万
-
财政年份:2022
-
负责人:Benjamin A Lopman
-
依托单位:
COVID-19 - Global Mix / Investigation of COVID-19 Disease Parameters for Transmission Models in Low-Resource Settings
-
批准号:10577833
-
项目类别:
-
资助金额:$27.01万
-
财政年份:2022
-
负责人:Benjamin A Lopman
-
依托单位:
COVID Global Mix - Global Mix / Investigation of COVID-19 Disease Parameters for Transmission Models in Low-Resource Settings
-
批准号:10863617
-
项目类别:
-
资助金额:$42.9万
-
财政年份:2022
-
负责人:Benjamin A Lopman
-
依托单位:
Comprehensive Profiling of Social Mixing Patterns in Resource Poor Countries
-
批准号:10397072
-
项目类别:
-
资助金额:$52.93万
-
财政年份:2019
-
负责人:Benjamin A Lopman
-
依托单位:
Comprehensive Profiling of Social Mixing Patterns in Resource Poor Countries
-
批准号:10610730
-
项目类别:
-
资助金额:$50.45万
-
财政年份:2019
-
负责人:Benjamin A Lopman
-
依托单位:
Integrating data streams with multi-scale modeling to guide norovirus vaccine decision-making
-
批准号:10160920
-
项目类别:
-
资助金额:$34.03万
-
财政年份:2018
-
负责人:Benjamin A Lopman
-
依托单位:
Modeling ongoing SARS-CoV2 vaccination strategies in light of emerging data on immunity and viral evolution
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批准号:10398368
-
项目类别:
-
资助金额:$17.31万
-
财政年份:2018
-
负责人:Benjamin A Lopman
-
依托单位:
海外基金