IVIS Spectrum CT imager for the Medical College of Wisconsin

威斯康星医学院的 IVIS Spectrum CT 成像仪

• 批准号: 10415248
• 负责人: AMIT JOSHI
• 金额: $ 59.87万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10415248
• 关键词: 3-Dimensional; Administrator; Advisory Committees; Anesthesia procedures; Animals; Bioluminescence; Biomedical Research; Businesses; Cancer Center; Clinical Sciences; Computer software; Contracts; Diffuse; Disease; Fluorescence; Funding; Human Resources; Image; Imaging Device; Infrastructure; Institutes; Institution; Investments; Ions; Maintenance; Medical Imaging; Minor; Mus; Optics; Pathogenesis; Research Personnel; Research Project Grants; Resolution; Resource Sharing; Rodent; Rodent Model; Schedule; Source; System; Three-Dimensional Imaging; Time; Translational Research; United States National Institutes of Health; Wisconsin; X-Ray Computed Tomography; animal imaging; biomedical imaging; charge coupled device camera; cherenkov imaging; detector; experience; imager; imaging modality; imaging platform; in vivo; in vivo imaging system; instrument; instrumentation; low dose computed tomography; medical schools; microCT; multimodality; operation; programs; reconstruction; serial imaging; tomography; treatment response

SUMMARY ABSTRACT We request funds to purchase a new IVIS Spectrum-CT instrument equipped with a thermoelectrically-cooled CCD camera, integrated optical and micro-CT sources and detectors, and 3D diffuse tomographic reconstruction software. The system includes bioluminescent and fluorescent phantom mouse software and a rodent anesthesia system. This instrument will be installed in the Biomedical Imaging Shared Resource (BISR) facility at the Medical College of Wisconsin (MCW). Since its creation in 2004, the BISR has supported the biomedical research programs of a diverse group of NIH-funded investigators at MCW and its partner institutions in the Clinical and Translational Science Institute (CTSI) of Southeastern Wisconsin. Consistent with its record of major investments in medical and biomedical imaging instrumentation and facilities, MCW has committed substantial matching funds to purchase the maintenance contract and provide technical support for the instrument. The IVIS Spectrum-CT provides 2D and 3D quantitative bioluminescence and multispectral fluorescence with low dose computed tomography (CT), spectral unmixing, and Cerenkov imaging currently unavailable in the obsolete optical and micro-CT instruments existing at MCW. Access to the requested fully integrated optical and micro-CT imaging platform will markedly benefit the research projects of eight federally funded (NIH, DOD) Major User investigators and four Minor User investigators as described in this application. These projects will benefit from the requested instrumentation thanks to increased resolution and sensitivity; spatial co-registration across imaging modalities; and the repeatable, non-invasive and minimally-ionizing examination that enables longitudinal imaging to track disease pathogenesis and treatment responses in rodent models. When installed, this instrument will be the only multimodal 3D imaging instrument for in vivo small animal imaging in Milwaukee and southeastern Wisconsin. The BISR is already equipped with the infrastructure and manned by the support staff required for installation and expert operation of the IVIS Spectrum-CT. The new instrument will be maintained by personnel experienced in operating and maintaining in vivo rodent imaging instrumentation, small animal anesthesia, and managing a multi-user recharge facility. Instrument time will be allocated using the existing BISR scheduling system implemented in iLabs. A standing local advisory committee will provide oversight. BISR financial operations are managed by the senior business administrator in the MCW Cancer Center. Acquisition of the IVIS Spectrum-CT instrument requested in this application will have a profound impact on NIH-funded biomedical research programs at MCW and its partner CTSI institutions.

摘要摘要 我们请求资金购买一台新的IVIS Spectrum-CT仪器，配备热电制冷 Ccd相机、集成光学和微型CT源和探测器以及三维漫反射层析重建 软件。该系统包括生物发光和荧光幻影老鼠软件和一只啮齿动物 麻醉系统。该仪器将安装在生物医学成像共享资源(BISR)设施中 在威斯康星医学院(MCW)。自2004年成立以来，BISR一直支持生物医学 美国国立卫生研究院资助的一批研究人员在妇幼保健院及其合作机构的研究计划 威斯康星州东南部的临床和翻译科学研究所(CTSI)。与它的主要记录一致 在医疗和生物医学成像仪器和设施方面的投资，MCW已投入大量资金 配套资金购买维修合同，为仪器提供技术支持。静脉注射用药系统 SPECTRUM-CT以低剂量提供2D和3D定量生物发光和多光谱荧光 计算机断层扫描(CT)、光谱分解和切伦科夫成像目前无法在过时 MCW现有的光学和微型CT仪器。 获得所要求的全集成光学和显微CT成像平台将显著有利于研究 八个联邦资助的(NIH，DOD)主要用户调查员和四个次要用户调查员的项目 在本申请中描述的。这些项目将受益于所要求的工具，这要归功于增加了 分辨率和灵敏度；跨成像模式的空间共配准；以及可重复的、非侵入性和 最低限度的电离检查，使纵向成像能够跟踪疾病的发病机制和治疗 在啮齿动物模型中的反应。安装后，该仪器将成为唯一的多模式3D成像仪器 用于密尔沃基和威斯康星州东南部的活体小动物成像。 BISR已经配备了基础设施，并配备了安装所需的支持人员 IVIS Spectrum-CT的专家操作。新仪器将由有经验的人员进行维护 在操作和维护体内啮齿动物成像仪器、小动物麻醉以及管理 多用户充值设施。仪器时间将使用现有的BISR调度系统进行分配 在iLabs中实施。一个常设的地方咨询委员会将提供监督。BISR财务运营是 由MCW癌症中心的高级业务管理员管理。IVIS频谱-CT的获取 申请中要求的仪器将对美国国立卫生研究院资助的生物医学研究产生深远影响 MCW及其合作伙伴CTSI机构的课程。