Laser Scanning Vibrometer

项目摘要 严格的生物力学研究依赖于准静态、动态和粘弹性表征。虽然这件事 被研究界很好地接受，实验限制，例如需要最小限度的操作 或持续的活体环境，极大地限制了生物力学研究的范围。鉴于……的主导作用 加州大学欧文分校(UCI)在生物力学和机械生物学方面，有很大的需求 创新的生物力学测试仪器，将使NIH资助的UCI研究人员能够探索许多 该领域的悬而未决的问题超出了UCI现有设备的能力。在这项提案中，我们 展示购买Polytec PSV-500-3D QTEC激光扫描测振仪的必要性，以支持 美国国立卫生研究院资助的众多研究项目。拟议中的振动仪能够表征动态和 没有损伤的复杂生物样品和生物材料的粘弹性性能是无与伦比的。这 该提案清楚地描述了UCI目前生物力学测试设备的主要缺陷。相比之下， 对于这些仪器，所提出的测振仪的优点是广泛的，包括快速非接触 测量、高分辨率3D扫描、多比例测量功能和便携性，其中 其他。这些特征对于在复杂研究中保持高要求的实验条件至关重要， 例如培养组织的纵向特征或与手术室同时进行的测量 程序。校园里或市场上没有其他仪器可以提供拟议的可控震源 独特的功能。本提案由Kyriacos Atanasiou(PI)博士、曾傑瑞·胡博士和加布里埃拉博士准备 埃斯皮诺萨与其他五个主要用户(Naomi Chesler博士、Anna Grosberg博士、Wendy Liu博士、Joshua博士)协商 Mauney，Ronke OLabisi)和三个未成年用户(陈忠平博士，Elliot Huliot，向良忠博士)。首字母 一组用户代表了工程学和医学的许多交叉领域，包括 机械生物学、生物微电子机械系统、组织工程和生物医学成像。它是 预计对拟议的可控震源使用的兴趣只会增加，从而扩大其对电流的影响 以及加州大学洛杉矶分校未来由NIH资助的研究。

Project Summary Rigorous biomechanical research relies on quasistatic, dynamic, and viscoelastic characterization. Although this is well accepted by the research community, experimental constraints, such as a need for minimal manipulation or a sustained in vivo environment, greatly limit the scope of biomechanical studies. Given the leading role of the University of California, Irvine (UCI) in biomechanics and mechanobiology, there is a significant need for innovative biomechanical testing instrumentation that will enable NIH-funded UCI researchers to probe many of the field’s unanswered questions beyond the capabilities of UCI’s existing equipment. In this proposal, we demonstrate the need for the purchase of a Polytec PSV-500-3D QTec Laser Scanning Vibrometer to support numerous NIH-funded research projects. The proposed Vibrometer’s ability to characterize the dynamic and viscoelastic properties of complex biological samples and biomaterials without damage is unparalleled. This proposal clearly delineates the major drawbacks of UCI’s current biomechanical testing equipment. In contrast to these instruments, the proposed Vibrometer’s advantages are extensive and include rapid contactless measurements, high resolution 3D scanning, multi-scale measurement capabilities, and portability, among others. These features are critical to maintaining highly demanding experimental conditions in complex studies, such as longitudinal characterization of cultured tissues or measurements concurrent with operating room procedures. There are no other instruments on campus or on the market that provide the proposed Vibrometer’s unique features. This proposal has been prepared by Drs. Kyriacos Athanasiou (PI), Jerry Hu, and Gabriela Espinosa in consultation with five other Major Users (Drs. Naomi Chesler, Anna Grosberg, Wendy Liu, Joshua Mauney, Ronke Olabisi) and three Minor Users (Drs. Zhongping Chen, Elliot Hui, Liangzhong Xiang). The initial set of Users represent numerous areas at the intersection of engineering and medicine, including mechanobiology, bio-microelectromechanical systems, tissue engineering and biomedical imaging. It is anticipated that interest in the proposed Vibrometer’s use will only increase, thus expanding its impact on current and future NIH-funded research at UCI.