Laser Scanning Vibrometer

激光扫描测振仪

• 批准号: 10415806
• 负责人: Kyriacos A Athanasiou
• 金额: $ 60万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-15 至 2023-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10415806
• 关键词: 3-Dimensional; Area; Biocompatible Materials; Biological; Biomechanics; California; Communities; Complex; Consultations; Engineering; Environment; Equipment; Funding; Future; Lasers; Measurement; Medicine; Minor; Operating Rooms; Procedures; Property; Research; Research Personnel; Research Project Grants; Resolution; Role; Sampling; Scanning; System; Tissue Engineering; Tissues; United States National Institutes of Health; Universities; biomechanical test; biomedical imaging; in vivo; innovation; instrument; instrumentation; interest; portability; viscoelasticity

Project Summary Rigorous biomechanical research relies on quasistatic, dynamic, and viscoelastic characterization. Although this is well accepted by the research community, experimental constraints, such as a need for minimal manipulation or a sustained in vivo environment, greatly limit the scope of biomechanical studies. Given the leading role of the University of California, Irvine (UCI) in biomechanics and mechanobiology, there is a significant need for innovative biomechanical testing instrumentation that will enable NIH-funded UCI researchers to probe many of the field’s unanswered questions beyond the capabilities of UCI’s existing equipment. In this proposal, we demonstrate the need for the purchase of a Polytec PSV-500-3D QTec Laser Scanning Vibrometer to support numerous NIH-funded research projects. The proposed Vibrometer’s ability to characterize the dynamic and viscoelastic properties of complex biological samples and biomaterials without damage is unparalleled. This proposal clearly delineates the major drawbacks of UCI’s current biomechanical testing equipment. In contrast to these instruments, the proposed Vibrometer’s advantages are extensive and include rapid contactless measurements, high resolution 3D scanning, multi-scale measurement capabilities, and portability, among others. These features are critical to maintaining highly demanding experimental conditions in complex studies, such as longitudinal characterization of cultured tissues or measurements concurrent with operating room procedures. There are no other instruments on campus or on the market that provide the proposed Vibrometer’s unique features. This proposal has been prepared by Drs. Kyriacos Athanasiou (PI), Jerry Hu, and Gabriela Espinosa in consultation with five other Major Users (Drs. Naomi Chesler, Anna Grosberg, Wendy Liu, Joshua Mauney, Ronke Olabisi) and three Minor Users (Drs. Zhongping Chen, Elliot Hui, Liangzhong Xiang). The initial set of Users represent numerous areas at the intersection of engineering and medicine, including mechanobiology, bio-microelectromechanical systems, tissue engineering and biomedical imaging. It is anticipated that interest in the proposed Vibrometer’s use will only increase, thus expanding its impact on current and future NIH-funded research at UCI.

项目摘要 严格的生物力学研究依赖于准静态、动态和粘弹性表征。虽然这 被研究界广泛接受，实验限制，如需要最小的操作 或持续的体内环境，极大地限制了生物力学研究的范围。鉴于领导作用， 加州大学欧文分校（UCI）的生物力学和机械生物学，有一个显着的需要， 创新的生物力学测试仪器，将使美国国立卫生研究院资助的UCI研究人员探测许多 该领域的悬而未决的问题超出了UCI现有设备的能力。在本提案中，我们 演示购买Polytec PSV-500-3D QTec激光扫描振动计的必要性，以支持 许多NIH资助的研究项目。所提出的振动计的能力，以表征动态和 粘弹性能对复杂生物样品和生物材料无损伤是无可比拟的。这 该提案清楚地描述了UCI目前生物力学测试设备的主要缺点。相比之下 相对于这些仪器，所提出的振动计的优点是广泛的，包括快速非接触 测量、高分辨率3D扫描、多尺度测量能力和便携性， 他人这些特征对于在复杂研究中维持高要求的实验条件至关重要， 例如培养组织的纵向表征或与手术室同时进行的测量 程序.校园内或市场上没有其他仪器可以提供建议的振动计 独特的功能。本提案由Kyriacos Athanasiou（PI）、Jerry Hu和Gabriela博士编写 埃斯皮诺萨与其他五位主要用户（Naomi Chesler、安娜Grosberg、Wendy Liu、约书亚博士）进行了磋商 Mauney，Ronke Olabisi）和三名未成年用户（Zhongping Chen，Elliot Hui，Liangzhong Xiang博士）。初始 一组用户代表了工程和医学交叉的许多领域，包括 机械生物学、生物微机电系统、组织工程和生物医学成像。是 预计对拟议中的振动计的使用的兴趣只会增加，从而扩大其对当前的影响， 以及UCI未来NIH资助的研究。