PAHs: New Technologies and Emerging Health Risks

PAH：新技术和新出现的健康风险

• 批准号: 10415776
• 负责人: Robyn L Tanguay
• 金额: $ 5万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10415776
• 关键词: Address; Aromatic Hydrocarbons; Aromatic Polycyclic Hydrocarbons; Behavioral; Bioinformatics; Biological; Biological Availability; Biomedical Research; Body Composition; Cardiovascular Diseases; Chemical Exposure; Chemicals; Chemistry; Communities; Complex; Complex Mixtures; DNA Damage; Data; Data Analyses; Devices; Disease; Disease Outcome; Environment; Environmental Engineering technology; Environmental Health; Environmental Science; Exposure to; Funding; Gene Expression; Goals; Grant; Hazard Models; Health; Health Hazards; Human; In Vitro; Individual; Laboratories; Link; Location; Lung; Lung diseases; Malignant Neoplasms; Measures; Metabolic; Metabolism; Mission; Modeling; Monitor; Movement; Oregon; Outcome; Pacific Northwest; Parents; Predisposition; Property; Quality of life; Research; Research Project Grants; Research Support; Risk; Risk Assessment; Sampling; Science; Scientist; Site; Soil; Superfund; System; Techniques; Technology; Testing; Time; Tissues; To specify; Toxic effect; Toxicity Tests; Training; Translational Research; UV Radiation Exposure; Universities; Work; Zebrafish; community engagement; data management; experience; frontier; hazard; improved; in vivo; innovation; instrumentation; multidisciplinary; new technology; next generation; novel; novel strategies; oxidation; programs; remediation; respiratory; success; superfund site; three dimensional cell culture; tool; transcriptomics

SUMMARY – OVERALL CENTER The Oregon State University Superfund Research Program (SRP), in partnership with Pacific Northwest National Laboratories and other stakeholders and collaborators, seeks to develop new technologies to identify the polycyclic aromatic hydrocarbon (PAHs) mixtures found at many of the nation's Superfund sites before and after remediation. We will identify novel hazard and toxicity mechanisms for PAHs and real-world PAH mixtures. The SRP will support three biomedical research projects and two environmental science and engineering projects. We aligned these research projects with the four SRP mandates to address pressing challenges at Superfund sites. The Administrative, Community Engagement, Chemical Mixtures, Research Experience and Training, and Data Management and Analysis cores support the research projects. This proposal builds on our successes during the previous grant period. Over the next five years, we will pursue innovative, high-impact research goals. For example, we propose to (1) develop the first generalizable technology to measure the movement of PAHs to and from Superfund sites, (2) measure external exposures to PAHs for individuals near Superfund sites and determine how their exposures vary as a function of location, (3) predict the secondary transformation products of PAHs that will form during biotic and abiotic remediation at Superfund sites, (4) predict the toxicity of complex PAH mixtures using zebrafish, (5) link PAH exposure to health outcomes with the aid of a powerful human in vitro respiratory model, and (6) elucidate metabolic and physicochemical control of PAH susceptibility in toxicity systems. The cores will (1) direct the activities of the SRP and disseminate our findings to stakeholders (Administrative), (2) work with communities impacted by PAH exposure to address concerns and reduce risk (Community Engagement); (3) provide intensive multi-disciplinary training for the next generation of Environmental Health Scientists (RETCC), (4) provide data management and analysis support (DMAC), and (5) apply state-of- the-art chemistry instrumentation and approaches to measure PAHs and PAH mixtures found in environmental and biological matrices. By accomplishing these goals, we will advance the frontiers of science and also improve the quality of life for impacted communities.

摘要 – 总体中心 俄勒冈州立大学超级基金研究计划 (SRP)，与 Pacific Northwest 合作 国家实验室和其他利益相关者和合作者寻求开发新技术 识别在美国许多超级基金地点发现的多环芳烃 (PAH) 混合物 修复前和修复后。我们将确定多环芳烃和现实世界的新危害和毒性机制 多环芳烃混合物。 SRP 将支持三个生物医学研究项目和两个环境科学和 工程项目。我们将这些研究项目与四项 SRP 任务结合起来，以解决紧迫的问题 超级基金网站的挑战。行政、社区参与、化学混合物、研究 经验和培训以及数据管理和分析核心支持研究项目。这 该提案建立在我们上一个资助期间取得的成功的基础上。未来五年，我们将追求 创新、高影响力的研究目标。例如，我们建议（1）开发第一个可推广的 测量多环芳烃进出超级基金场地的移动的技术，(2) 测量外部暴露 超级基金地点附近的个人的多环芳烃，并确定他们的暴露如何随着以下因素的变化而变化： 位置，（3）预测生物和非生物过程中形成的PAHs的二次转化产物 超级基金站点的修复，(4) 使用斑马鱼预测复杂 PAH 混合物的毒性，(5) 链接 借助强大的人体体外呼吸模型，PAH 暴露对健康结果的影响，以及 (6) 阐明毒性系统中 PAH 敏感性的代谢和理化控制。核心将 (1) 指导 SRP 的活动并将我们的调查结果传播给利益相关者（行政），(2) 与 受多环芳烃暴露影响的社区解决问题并降低风险（社区参与）； (3) 为下一代环境健康科学家提供强化的多学科培训 (RETCC)，(4) 提供数据管理和分析支持 (DMAC)，以及 (5) 应用最先进的技术 测量环境和环境中发现的多环芳烃和多环芳烃混合物的化学仪器和方法 生物基质。通过实现这些目标，我们将推进科学前沿并提高 受影响社区的生活质量。