Modernization of an Integrated Specific Pathogen Free Zebrafish Core Facility

综合无特定病原体斑马鱼核心设施的现代化

• 批准号: 10796466
• 负责人: Robyn L Tanguay
• 金额: $ 752.85万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-06 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10796466
• 关键词: Area; Biomedical Research; Chemicals; Core Facility; Cryopreservation; Dedications; Economics; Ecosystem; Engineering; Ensure; Fiber Optics; Fishes; Funding; Goals; Growth; Health; Housing; Image; Individual; Laboratory Research; Life; Life Support Systems; Modeling; Modernization; Molecular Biology; Oregon; Planet Earth; Quarantine; Research; Research Personnel; Research Support; Resources; Science; Services; Speed; System; United States National Institutes of Health; Universities; Walking; Zebrafish; base; behavioral study; data exchange; design; feeding; germ free condition; medical specialties; meetings; multidisciplinary; optical fiber; programs; remote monitoring; research facility; screening; social; technological innovation

PROJECT SUMMARY The Oregon State University Sinnhuber Aquatic Research Laboratory (SARL) is seeking funds to modernize an integrated specific pathogen-free zebrafish core facility. Our NIH biomedical research base has grown exponentially over the past decade and renovation, and modernization will ensure that it remains a critical resource to support research growth for well-established NIH Centers, individual NIH-supported investigators, and other stakeholder partners. The SARL supports Oregon State University’s thematic research areas: the science of sustainable earth ecosystems, health and wellness, and economic prosperity and social progress. Completion of this project will provide modern, sustainable, specific pathogen-free zebrafish housing space, specialty research space, and efficient fish life support and husbandry systems. Our overarching goals are to 1) Renovate an existing 3,500 ft2 purpose-built aquatic facility into a highly researcher-accessible zebrafish housing facility, 2) Replace obsolete and undersized zebrafish life support system, 3) Install modern zebrafish housing enhanced by automated cleaning, feeding, and remote monitoring, 4) Build specialty zebrafish rooms to support short and long term flow-through studies, 5) Add high capacity tank washing capabilities, and 6) Provide engineering space to further seed technological innovations. This renovation will be part of an existing research building with 10,000 ft2 of renovated space that houses a fully automated zebrafish high throughput chemical screening facility, modern imaging and molecular biology rooms, a 2,300 ft2 room for zebrafish behavioral studies, dedicated quarantine rooms, walk-in cold storage rooms, high- speed fiber-optic data transmission, large researcher office spaces, and modern meeting rooms. A key design principle for the SARL is that it seeds multidisciplinary interactions by providing a full menu of services. The SARL nucleates research programs through aggressive promotion of the zebrafish model. Completing this modernization project will address bottlenecks limiting further growth of zebrafish biomedical research. This proposal is part of the long-term commitment to developing and maintaining advanced aquatic biomedical research facilities at Oregon State University, the region, and nationally.

项目总结 俄勒冈州立大学辛胡伯水生研究实验室(SARL)正在寻求资金，以 对综合的无特定病原体的斑马鱼核心设施进行现代化改造。我们的NIH生物医学研究 基地在过去十年里呈指数级增长，翻新，现代化将确保 它仍然是支持知名NIH中心研究增长的关键资源，个人 NIH支持的调查人员和其他利益相关者合作伙伴。SARL支持俄勒冈州 大学的主题研究领域：可持续地球生态系统科学、健康与健康、 经济繁荣和社会进步。该项目的竣工将提供现代化的、 可持续的、无特定病原体的斑马鱼栖息地、专业研究空间和高效鱼 生命支持和畜牧业系统。我们的首要目标是1)翻新现有的3,500英尺2 将专门建造的水上设施改造成便于研究人员使用的斑马鱼收容所，2)更换 陈旧和尺寸过小的斑马鱼生命支持系统，3)安装现代斑马鱼外壳增强 通过自动清洁、喂养和远程监控，4)建立专门的斑马鱼室以支持 短期和长期直通研究，5)增加高容量水箱清洗能力，6) 为进一步播种技术创新提供工程空间。这次翻修将是 现有的研究大楼，有10,000平方英尺的翻新空间，里面有一条全自动斑马鱼 高通量化学筛选设施，现代成像和分子生物室，2300平方英尺 斑马鱼行为研究的空间，专用检疫室，步入式冷藏室，高 高速光纤数据传输、大型研究人员办公空间和现代化会议室。一把钥匙 SARL的设计原则是，它通过提供完整的菜单来促进多学科互动 服务。SARL通过积极推广斑马鱼模型来启动研究计划。 完成这一现代化项目将解决限制斑马鱼进一步生长的瓶颈 生物医学研究。这项建议是长期致力于开发和维护 俄勒冈州立大学、该地区和全国的先进水生生物医学研究设施。