Development and Initial Efficacy Testing of a Cognitive-Behavioral Intervention to Treat Adolescent Binge Eating

项目总结/摘要 暴饮暴食的情节包括吃了异常大量的食物和感觉无法控制的类型 或吃东西时吃的食物量。在青少年中，饮食失控是一种前兆， 体重过度增加和暴食症暴饮暴食也与身体和精神 健康受损和心理社会困扰。虽然超重和暴饮暴食有严重的 直接和长期后果、评估和治疗受到的关注很少， 青少年患者在成年人中，认知行为疗法（CBT）对狂欢有很强的证据基础， 饮食失调在青少年中，对于暴饮暴食没有成熟的治疗方法。 青少年因其发育阶段而具有独特的社会、认知和情感需求; 治疗方法对于满足这些独特需求至关重要。这项指导性的以患者为导向的研究 职业发展奖（K23与临床试验）建立在候选人的程序性临床- 研究兴趣在于治疗体重和饮食失调。培训目标和研究活动 该K23将在（a）治疗开发和初步疗效测试方面开发新的技能和专业知识， 行为疗法研究阶段模型所描述的，和（B）高级统计技能， 重复和二元数据。针对青少年暴食/暴饮暴食的CBT的发展将对 有助于我们理解治疗，这是减少健康损害的重要一步， 与青少年暴饮暴食和超重有关的心理社会痛苦。研究活动 与培训活动紧密结合，并由国际公认的顾问团队提供指导 学者，以促进候选人的必要技能的发展，成为一个独立的和有影响力的 儿童肥胖和饮食失调领域的研究员。 该培训计划招募了精神病学和心理学教授卡洛斯格里洛博士的指导， 耶鲁大学肥胖、体重和饮食研究项目主任，温迪·西尔弗曼博士，阿尔弗雷德·A。 梅塞尔教授在耶鲁大学儿童研究中心和心理学教授和主任耶鲁大学儿童 焦虑症研究中心计划。格里洛医生在治疗成人暴饮暴食方面的专长 西尔弗曼博士在青少年治疗方面的专业知识补充了他对疾病和肥胖的研究。在一起，他们 导师制将有助成功推行建议的研究目标及事业目标。研究 培训活动还将利用耶鲁大学的其他临床研究教育项目（例如，CTSA， 心理治疗发展中心），提供许多正式的培训活动，机会和资源。 技能（治疗开发和高级统计分析）将产生新的治疗方法和初步疗效 这些数据将用于未来对候选人整个职业生涯的效力和有效性进行测试。

PROJECT SUMMARY/ ABSTRACT Binge-eating episodes involve eating an unusually large amount of food and feeling unable to control the type or amount of food consumed while eating. Among adolescents, loss-of-control (LOC) eating is a precursor to excess weight gain and binge-eating disorder. Binge/LOC eating is also associated with physical and mental health impairments, and psychosocial distress. Although excess weight and binge/LOC eating have serious immediate and long-term consequences, assessment and treatment have received minimal attention for adolescent patients. Among adults, cognitive-behavioral therapy (CBT) has a strong evidence base for binge- eating disorder. Among adolescents, there are no well-established treatments for binge/LOC eating. Adolescents have unique social, cognitive and emotional needs because of their developmental stage; unique treatment approaches are essential to meet these unique needs. This Mentored Patient-Oriented Research Career Development Award (K23 with Clinical Trial) builds upon the candidate’s programmatic clinical- research interest in the treatment of weight and eating disorders. Training objectives and research activities for this K23 are to develop new skills and expertise in (a) treatment development and initial efficacy testing as described by the Stage Model of Behavioral Therapies Research, and (b) advanced statistical skills for repeated and dyadic data. Development of CBT for adolescent binge/LOC eating will make a significant contribution to our understanding of treatment in an important step towards reducing health impairments and psychosocial distress associated with adolescent binge/LOC eating and excess weight. Research activities are tightly integrated with training activities and mentorship from an advisory team of internationally-recognized scholars to facilitate the candidate’s development of necessary skills to become an independent and impactful investigator in the fields of childhood obesity and eating disorders. The training plan enlists the mentorship of Carlos Grilo, PhD, Professor of Psychiatry and Psychology and Director of the Yale Program for Obesity, Weight, and Eating Research, and Wendy Silverman, PhD, Alfred A. Messer Professor in the Yale Child Study Center and Professor of Psychology and Director of the Yale Child Study Center Program for Anxiety Disorders. Dr. Grilo’s expertise in the treatment of adult binge-eating disorder and obesity is complemented by Dr. Silverman’s expertise in youth treatments. Together, their mentorship will facilitate successful execution of the proposed research aims and career objectives. Research and training activities will also make use of other clinical-research educational programs at Yale (e.g., CTSA, Psychotherapy Development Center) that offer many formal training activities, opportunities, and resources. Skills (treatment development and advanced statistical analysis) will yield a new treatment and initial efficacy data for future tests of efficacy and effectiveness throughout the candidate’s career.