Development and Initial Efficacy Testing of a Cognitive-Behavioral Intervention to Treat Adolescent Binge Eating

治疗青少年暴食的认知行为干预措施的开发和初步疗效测试

• 批准号: 10416090
• 负责人: Janet A Lydecker
• 金额: $ 19.49万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10416090
• 关键词: Adolescent; Adolescent Development; Adult; Advisory Committees; Advocate; Anxiety Disorders; Attention; Award; Behavior; Behavior Control; Behavioral Model; Behavioral inhibition; Binge Eating; Binge eating disorder; Body mass index; Child; Clinical; Clinical Research; Clinical Trials; Cognitive; Cognitive Science; Cognitive Therapy; Complement; Consult; Control Groups; Data; Decision Making; Development; Distress; Doctor of Philosophy; Eating; Eating Disorders; Effectiveness; Emotional; Evidence based treatment; Feedback; Feeling; Focus Groups; Food; Foundations; Frequencies; Funding; Future; Grant; Health; Healthy Eating; Height; Impaired health; Impulsivity; International; Intervention; Lead; Learning; Manuals; Measures; Mediator of activation protein; Mental Depression; Mental Health; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methodology; Obesity; Parents; Patients; Pattern; Persons; Pilot Projects; Positioning Attribute; Process; Protocols documentation; Psychiatry; Psychology; Psychotherapy; Randomized; Research; Research Activity; Research Personnel; Research Training; Resources; Rewards; Series; Statistical Data Interpretation; Testing; Therapeutic Studies; Thinking; Training; Training Activity; Weight; Youth; active control; adolescent patient; adult obesity; base; career; career development; cognitive development; effectiveness trial; efficacy testing; efficacy trial; evidence base; excessive weight gain; executive function; experience; food consumption; high risk; improved; individualized medicine; insight; interest; interpersonal therapy; loss of control over eating; obesity in children; physical conditioning; pilot test; professor; programs; psychosocial; research and development; secondary outcome; self esteem; skills; social; statistics; therapy design; therapy development; treatment planning

PROJECT SUMMARY/ ABSTRACT Binge-eating episodes involve eating an unusually large amount of food and feeling unable to control the type or amount of food consumed while eating. Among adolescents, loss-of-control (LOC) eating is a precursor to excess weight gain and binge-eating disorder. Binge/LOC eating is also associated with physical and mental health impairments, and psychosocial distress. Although excess weight and binge/LOC eating have serious immediate and long-term consequences, assessment and treatment have received minimal attention for adolescent patients. Among adults, cognitive-behavioral therapy (CBT) has a strong evidence base for binge- eating disorder. Among adolescents, there are no well-established treatments for binge/LOC eating. Adolescents have unique social, cognitive and emotional needs because of their developmental stage; unique treatment approaches are essential to meet these unique needs. This Mentored Patient-Oriented Research Career Development Award (K23 with Clinical Trial) builds upon the candidate’s programmatic clinical- research interest in the treatment of weight and eating disorders. Training objectives and research activities for this K23 are to develop new skills and expertise in (a) treatment development and initial efficacy testing as described by the Stage Model of Behavioral Therapies Research, and (b) advanced statistical skills for repeated and dyadic data. Development of CBT for adolescent binge/LOC eating will make a significant contribution to our understanding of treatment in an important step towards reducing health impairments and psychosocial distress associated with adolescent binge/LOC eating and excess weight. Research activities are tightly integrated with training activities and mentorship from an advisory team of internationally-recognized scholars to facilitate the candidate’s development of necessary skills to become an independent and impactful investigator in the fields of childhood obesity and eating disorders. The training plan enlists the mentorship of Carlos Grilo, PhD, Professor of Psychiatry and Psychology and Director of the Yale Program for Obesity, Weight, and Eating Research, and Wendy Silverman, PhD, Alfred A. Messer Professor in the Yale Child Study Center and Professor of Psychology and Director of the Yale Child Study Center Program for Anxiety Disorders. Dr. Grilo’s expertise in the treatment of adult binge-eating disorder and obesity is complemented by Dr. Silverman’s expertise in youth treatments. Together, their mentorship will facilitate successful execution of the proposed research aims and career objectives. Research and training activities will also make use of other clinical-research educational programs at Yale (e.g., CTSA, Psychotherapy Development Center) that offer many formal training activities, opportunities, and resources. Skills (treatment development and advanced statistical analysis) will yield a new treatment and initial efficacy data for future tests of efficacy and effectiveness throughout the candidate’s career.

项目摘要/摘要 暴饮暴食包括吃得异常多，感觉无法控制类型 或进食时所消耗的食物量。在青少年中，失控进食(LOC)是 体重超标和暴饮暴食。暴饮暴食也与身体和精神有关 健康受损和心理社会苦恼。虽然超重和暴饮暴食严重 近期和长期后果、评估和治疗受到的关注微乎其微。 青少年患者。在成年人中，认知行为疗法(CBT)对暴饮暴食有很强的证据基础。 进食障碍。在青少年中，没有公认的暴饮暴食的治疗方法。 青少年因其发展阶段而有独特的社交、认知和情感需求；独特的 治疗方法对于满足这些独特的需求是必不可少的。这指导了以患者为导向的研究 职业发展奖(K23临床试验)建立在候选人的方案临床- 对治疗体重和饮食失调的研究感兴趣。的培训目标和研究活动 K23将在(A)治疗开发和初步疗效测试方面开发新的技能和专业知识 由行为疗法研究的阶段模型描述，和(B)高级统计技能 重复和二元数据。针对青少年暴饮暴食的CBT的开发将对 有助于我们对治疗的理解，这是减少健康损害和 与青少年暴饮暴食和超重有关的心理社会苦恼。研究活动有 与培训活动和来自国际公认的顾问团队的指导紧密结合 帮助考生培养必要的技能，成为独立有影响力的人 儿童肥胖症和饮食失调领域的研究员。 培训计划征集了卡洛斯·格里洛博士的指导，他是精神病学和心理学教授， 耶鲁大学肥胖、体重和饮食研究项目主任，温迪·西尔弗曼博士，阿尔弗雷德·A。 梅塞尔，耶鲁儿童研究中心教授，心理学教授，耶鲁儿童中心主任 焦虑症研究中心项目。格里洛医生在治疗成人暴饮暴食方面的专业知识 西尔弗曼博士在青少年治疗方面的专业知识为疾病和肥胖症提供了补充。在一起，他们的 指导将有助于成功执行拟议的研究目标和职业目标。研究 培训活动还将利用耶鲁大学的其他临床研究教育计划(例如，CTSA、 心理治疗发展中心)，提供许多正式的培训活动、机会和资源。 技术(治疗发展和高级统计分析)将产生新的治疗方法和初步疗效 为未来对候选人职业生涯中的有效性和有效性进行测试的数据。