Center for Advancing Multimorbidity Science: Profiling risk and symptom expression to develop customized therapies for adults with multiple chronic conditions (CAMS)

促进多发病科学中心：分析风险和症状表达，为患有多种慢性病的成人开发定制疗法 (CAMS)

• 批准号: 10416005
• 负责人: KEELA A HERR
• 金额: $ 20.1万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-13 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10416005
• 关键词: Adult; Collaborations; Common Data Element; Data Analyses; Development; Discipline of Nursing; Electronic Health Record; Ensure; Faculty; Fatigue; Fostering; Foundations; Funding; Future; Grant; Healthcare; Intervention; Measurement; Mentors; Mentorship; Methodology; Nurses; Nursing Faculty; Pain; Pilot Projects; Postdoctoral Fellow; Progress Reports; Recommendation; Records; Research; Research Personnel; Research Project Grants; Resources; Risk; SF-36; Science; Scientist; Series; Service provision; Source; Symptoms; Techniques; Testing; Training; Translating; Universities; Well in self; Writing; career; college; data harmonization; data integration; data management; data quality; data sharing; data standards; effectiveness evaluation; experience; improved; individualized medicine; member; multiple chronic conditions; novel; programs; skill acquisition; skills; skills training; success; training opportunity

The Pilot Administrative Core seeks to increase the number and quality of independent, externally funded investigators who advance the science on adults with MCC, using risk profiling to support surveillance and anticipation of symptom experience so that customized therapies can be developed and tested. It will be responsible to 1) arrange and preside over scientific merit review of pilot projects, 2) ensure that advising and oversight plans are followed, 3) evaluate the effectiveness of mentoring plans in preparing Pilot PIs for independent research careers, 4) maintain records of pilot proposal reviews and ensure completion of annual progress reports of all funded pilots, 5) guide the pilot projects in fostering future collaborations and R-series grants that will translate into therapies and interventions, 6) facilitate dissemination of pilot project findings, 7) make recommendations to the Internal Executive Committee on pilot project funding decisions and regarding the termination or corrective actions for pilot projects, and 8) along with the Integrative Analytics Core and Enrichment Program, promote training opportunities within the Center and with the College and University. The Pilot Administrative Core has four specific aims: 1. Efficiently and effectively administer the pilot project program within the Center, including the selection and implementation of meritorious pilot projects. 2. Provide strong mentorship through a mentoring team for each Pilot PI that includes guidance in grant management, research team collaboration, methodology, measurement, data management and analyses, scientific writing, grant development, survival skills training, and mentorship skill development. 3. Ensure data harmonization through the incorporation of the Common Data Elements (CDE), including the NINR demographic CDEs and at least two of the required CDEs (PROMIS-Pain, PROMIS-Fatigue, and Psychological well-being-SF-36) into the aims of each Pilot Project. 4. Coordinate advanced training in emerging analytical techniques with the Integrative Analytic Core to expand and enrich the research skills of Pilot PIs and their research teams and increase the number of nursing faculty with expertise in traditional and novel research leading to customized therapies. These functions are essential for the successful transition of Pilot PIs into independent researchers and for facilitation of data sharing and standardization to improve data quality and enable data integration from multiple studies and sources, including electronic health records. We are convinced that systematic provision of these services is needed for the successful completion of the Center's research projects.

试点行政核心旨在增加独立的、外部的 资助了研究人员，他们利用风险分析来支持MCC成人的科学研究， 监测和预测症状体验，以便开发定制的治疗方法， 测试.它将负责1）安排和主持试点项目的科学择优评审，2） 确保咨询和监督计划得到遵守，3）评估辅导计划的有效性， 为独立的研究事业准备试点PI，4）保持试点提案审查的记录， 确保完成所有受资助试点的年度进展报告，5）指导试点项目， 未来的合作和R系列赠款将转化为治疗和干预措施，6）促进 传播试点项目的调查结果，7）向内部执行委员会提出建议， 试点项目供资决定以及关于试点项目的终止或纠正行动，以及8） 沿着集成分析核心和丰富计划， 中心和学院和大学。试点行政核心有四个具体目标： 1.有效地管理中心内的试点项目，包括 选择和实施有价值的试点项目。 2.通过指导团队为每个试点PI提供强有力的指导，包括赠款指导 管理、研究团队协作、方法、测量、数据管理和 分析、科学写作、赠款开发、生存技能培训和指导技能 发展 3.通过纳入通用数据元素（CDE），确保数据统一， 包括NINR人口统计学CDE和至少两个所需的CDE（PROMIS-Pain， 承诺-疲劳和心理健康-SF-36）纳入每个试点项目的目标。 4.协调新兴分析技术的高级培训与综合分析核心， 扩大和丰富试点PI及其研究团队的研究技能， 在传统和新颖的研究，导致定制的治疗专业知识的护理学院。 这些职能对于试点PI成功过渡为独立研究人员至关重要， 促进数据共享和标准化，以提高数据质量并实现数据整合 来自多个研究和来源，包括电子健康记录。我们相信，系统 提供这些服务是成功完成中心研究项目所必需的。