Summer Environmental Health Sciences Training Program

摘要： 本提案是T35短期医学生暑期培训的竞争性续签申请 环境健康科学研究计划，已由NIEHS资助了15年。具体 目的是：1）为医疗机构提供基础和临床环境健康研究方面的实践培训 学生在一个结构化的，指导的环境; 2）提供一个互动的，教育的经验， 向医学生介绍基础，翻译和临床所需的基本技能 环境卫生科学基础研究。在研究跟踪的区别（ESTA），一个功能添加到 上一个奖项期间，加强了我们的学生作为环境健康科学的培训 专家在学术健康中心设置。这个NIEHS T35培训计划鼓励学生 在第二至第四年的医学培训中，参加持续的纵向研究经验， 使他们能够发展以研究为导向的技能，以完成临床或转化研究项目， 第三/第四年。出版经同行审查的文章，一些受训人员已经做到了这一点， 住院医师培训的强度和作为医生-科学家的第一个永久职位作为成果进行跟踪。 该计划将支持8名二年级医学生在环境健康科学研究方面的培训 与化学品暴露引起的慢性疾病有关的主题，包括糖尿病、非酒精性脂肪肝 疾病、肥胖、癌症和新陈代谢的激素调节。UofL医学院的学生在前半部分的 一年级学生从医学院和公立学校的23位导师提交的研究项目中选择 健康（兴趣排名1-5）。将被任命接受T35培训补助金的受训人员是在下列条件下选定的： 学员和导师之间的个人会议，以确保“适合”。成功地招募了 来自代表性不足的少数民族和弱势背景的学生。在为期11周的夏季 培训，学生与导师在临床或实验室环境中进行研究项目，并完成 在负责任的研究行为的培训（主题包括：再现性，制造和伪造 数据，剽窃，管理科学数据，出版实践，指导，负责任的作者， 利益冲突（Conflict of Interest）。与人类受试者一起工作的受训者完成人类受试者和IRB 在开始研究之前进行培训。在导师实验室使用脊椎动物的学员完成和 通过IACUC培训课程。所有学员将参加每周一次的“环境健康科学会议” 旨在向T35学员介绍环境健康科学的临床和转化研究。的 会议的高潮是每个学员向同行和导师介绍他/她的研究项目。学员 在医学院为期一周的研究中， 庆祝活动，包括国家认可的医生，科学家作为主旨发言人。海报比赛 获奖者有资格参加全国学生研究论坛明年春天。

Abstract: This proposal is a competing renewal application for a T35 short term medical student summer training program in environmental health science research that has been funded by NIEHS for 15 years. The Specific Aims are: 1) To provide hands-on training in basic and clinical environmental health-based research to medical students in a structured, mentored environment; 2) To provide an interactive, educational experience that introduces medical students to the fundamental skills necessary for basic, translational, and clinical Environmental Health Sciences-based research. The Distinction in Research Track (DIR), a feature added in the previous award period, enhances training for our students to function as environmental health sciences specialists in an academic health center setting. This NIEHS T35 training program encourages students to participate in the DIR for a continued longitudinal research experience in the 2nd – 4th years of medical training, allowing them to develop research-oriented skills to complete a clinical or translational research project in the third/fourth years. Publication of peer-reviewed articles, as some trainees have achieved, as well as the strength of residency training and first permanent position as physician-scientists are tracked as outcomes. The program will support training of 8 second year medical students in environmental health sciences research topics related to chemical exposure induced chronic diseases including diabetes, non-alcoholic fatty liver disease, obesity, cancer and hormonal regulation of metabolism. UofL medical students in the top half of the first year class choose from research projects submitted by 23 mentors in the Schools of Medicine and Public Health (ranking them 1-5 for interest). Trainees to be appointed to the T35 training grant are selected after in- person meetings between trainees and mentors to assure `fit'. A successful effort has been made to recruit students from underrepresented minorities and disadvantaged backgrounds. During the 11-week summer training, students work with mentors on their research project in clinical or laboratory settings and complete training in the Responsible Conduct of Research (topics include: reproducibility, fabrication and falsification of data, plagiarism, managing scientific data, publication practices, mentorship, responsible authorship, stewardship, conflict of interest). Trainees working with human subjects complete human subject and IRB training prior to beginning their research. Trainees who use vertebrate animals in mentors' labs complete and pass IACUC training courses. All trainees will attend a weekly “Environmental Health Sciences Conference” designed to introduce clinical and translational research in environmental health sciences to T35 trainees. The conference culminates with each Trainee presenting his/her research project to peers and mentors. Trainees also present the results of their research as posters with peers at a School of Medicine week-long research celebration that includes nationally recognized physician-scientists as keynote speakers. Poster contest Winners are eligible to attend the National Student Research Forum the following Spring.