SARRP with Cone Beam CT and bioluminescence imaging guidance

项目名称：采用锥束CT和生物发光成像引导的SARRP 项目摘要/摘要 拟收购Xstrahl生命科学200小动物辐射仪，小动物 辐射研究平台(SARRP)将为3D生物发光光学成像提供新的能力 肯塔基大学，以满足NIH资助的16名研究人员的需求，他们的研究项目有一个 迫切需要能够从多个角度将高共形辐射传输到 临床前小动物模型，具有模拟临床放射治疗的剂量分布的图像引导。 Xstrahl的SARRP系统能够从多个非 共面角度。此外，集成计算机断层扫描(CT)和生物发光等功能 体层摄影术(BLT)提供有关肿瘤的精确几何和生物学信息，使基本的 科学家们为了更好地模拟临床上使用的放射治疗的提供，以及监测 非侵入性放射治疗。该仪器在临床前放射治疗中提供了高精度， 这使得对肿瘤的高剂量和对有风险的器官的低剂量被证明是高局部的 控制，毒性更低，并有可能将先进的高精度新发现转化为更全面的 在临床实践中生存。该仪器平台将安装在加州大学的一个共享设施中 肯塔基州毒理学和癌症生物学系满足了对癌症生物学的强烈需求 研究人员将模拟临床放射治疗，并将支持23项现行赠款(21项由美国国立卫生研究院资助)， 所有这些都涉及到辐射的使用。重要的是，SARRP提供的新仪器能力将 更换两个老化的放射性同位素(铯)辐射器，这些辐射器的使用寿命即将结束，并且 构成安全风险。这些系统缺乏有效的定向辐射传输手段。因此，新的 该仪器将为显著增强的研究结果提供卓越的精确波束定向。这个 大学还拥有一套千伏X射线盒系统，用于辐射研究。然而，这个系统完全是 不适合现代研究发现，因为它缺乏提供倾斜光束的能力，并且 因此主要用于细胞照射。Xstrahl仪器的加入将大大增强 肯塔基大学国家癌症研究所内的癌症生物学研究-指定癌症 该中心包括大量在癌症生物学和辐射方面具有专业知识的成员 研究。拥有19个R01或同等资助金的13个主要用户和3个次要用户将组成初始用户 SARRP的基地。还将制定详细的推广计划，以吸引更多的研究人员使用这一技术 乐器。肯塔基大学已经做出了重大的机构承诺，以确保成功 在安装后使用该设备，从而确保高端癌症研究和 小动物照射的最新技术。

Project title: SARRP with Cone Beam CT and bioluminescence imaging guidance Project Summary/Abstract The proposed acquisition of the Xstrahl Life Sciences 200 Small Animal Radiation Instrument, a small animal radiation research platform (SARRP), will provide new capabilities for 3D bioluminescent optical imaging at the University of Kentucky to meet the needs of 16 NIH-funded investigators whose research programs have a critical need for instrumentation that is capable of delivering highly conformal radiation from multiple angles to preclinical small animal models with image guidance for a dose distribution mimicking clinical radiotherapy. The SARRP system from Xstrahl is able to provide precise irradiation to a small animal from multiple non- coplanar angles. In addition, features such as integrated computed tomography (CT) as well as bioluminescent tomography (BLT) provide precise geometric and biological information about the tumor, allowing basic scientists to better model delivery of radiation therapy that is used clinically, as well as to monitor the effects of radiation therapy non-invasively. The instrument offers high precision in preclinical radiation therapy treatment, which enables a higher dose to the tumor with lower dose to organs at risk with demonstrated high local control, less toxicity and the potential to translate advanced new high-precision findings to increased overall survival in clinical practice. This instrument platform to be housed in a shared use facility in the University of Kentucky’s Department of Toxicology and Cancer Biology addresses a strong need for cancer biology researchers to mimic clinical radiotherapy treatment and will support 23 active grants (21 funded by the NIH), all of which involve the use of radiation. Importantly, the new instrument capabilities offered by the SARRP will replace two aging radio-isotopic (Cesium) based irradiators that are at the end of their useful life stage and that pose a security risk. These systems lack an effective means for targeted radiation delivery. Thus, the new instrument will provide superior precision beam targeting for significantly enhanced research results. The university also has a kV x-ray boxed system for radiation research. However, this system is completely inadequate for modern research discovery, as it lacks the capability to deliver an angled beam and has therefore been used primarily for cell irradiation. The addition of this Xstrahl instrument will greatly enhance cancer biology research within the University of Kentucky’s National Cancer Institute-designated Cancer Center, which encompasses large numbers of members with expertise in cancer biology and radiation research. Thirteen major users with 19 R01 or equivalent grants and three minor users will form the initial user base for the SARRP. Detailed outreach plans will also be established to attract more researchers to use this instrument. University of Kentucky has made a significant institutional commitment to ensure the successful use of the device after its installation, thereby ensuring operational continuity of high-end cancer research and the latest technology in small animal irradiation.