"Small Animal Radiation Research Platform (SARRP) for Yale University".

“耶鲁大学小动物辐射研究平台（SARRP）”。

• 批准号: 10416546
• 负责人: Joseph N. Contessa
• 金额: $ 60万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-15 至 2024-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10416546
• 关键词: Address; Advisory Committees; Anatomy; Animals; Antibody Therapy; Brain; Cancer Biology; Clinical; Data Analyses; Devices; Distant; Dose; Experimental Designs; Funding; Immune system; Immunotherapy; Institution; Lesion; Normal tissue morphology; Organ; Protocols documentation; Radiation; Radiation Dose Unit; Radiation Interaction; Radiation therapy; Radiosurgery; Regimen; Research; Research Personnel; Research Project Grants; Rodent Model; Science; Site; Technology; Tissues; Tumor Biology; Tumor Tissue; United States National Institutes of Health; Universities; X-Ray Computed Tomography; Yale Cancer Center; base; cone-beam computed tomography; experience; gene therapy; image guided; improved; instrument; irradiation; novel; radiation delivery; radiation effect; recruit; small molecule; treatment planning; treatment response; tumor

PROJECT SUMMARY: Investigators at our institution have used translational rodent models to examine the effects of radiation on tumors and normal tissues since 1955. Today our radiation research is largely focused on sensitizing tumors to radiation therapy by introducing novel small molecule, antibody, immunologic, or genetic therapies. However, standard orthovoltage delivery devices are unable to recapitulate clinical radiation protocols. They do not provide accuracy or homogeneity of dose delivery, targeting of discrete lesions or organs, sparing of normal tissues, or the dose-volume calculations essential for understanding tissue exposures. The small animal radiation research platform (SARRP)-200 PRO addresses these limitations and enables target-based treatment planning using an integrated cone beam CT scan (CBCT) and image guided micro-irradiation. The SARRP will be integrated in to the Yale Cancer Center Irradiator Core and its specialized use will also be overseen by the PI and an advisory committee. The instrument will support several ongoing NIH funded research projects in cancer biology, enhance experimental designs, and improve data analysis and interpretation. Examples of how the SARRP will augment ongoing research are readily available. The SARRP will improve target localization within the brain, a site investigated by many projects at Yale, as well as other anatomic sites. It will enable delivery of radiosurgery, required by several investigators that seek to reproduce clinical scenarios with high radiation dose per fraction regimens. It will also provide the ability to study the interactions of radiation with normal tissue and the immune system, and to evaluate therapeutic responses at local, regional, and distant sites following irradiation. The use of SARRP guided radiation delivery is also anticipated to recruit new users, provide educational experience with this technology for trainees, and significantly expand research in tumor biology and the radiation sciences.

项目摘要： 我们机构的研究人员已使用翻译啮齿动物模型来检查辐射对 自1955年以来的肿瘤和正常组织。今天，我们的辐射研究主要集中于使肿瘤敏感 通过引入新型的小分子，抗体，免疫学或基因疗法来放射治疗。 但是，标准的矫正装置无法概括临床辐射方案。他们 不要提供剂量输送的准确性或同质性，定位离散病变或器官的靶向 正常组织，或对了解组织暴露至关重要的剂量体积计算。小 动物辐射研究平台（SARRP）-200 PRO解决这些局限性并启用基于目标的限制 使用集成锥束CT扫描（CBCT）和图像引导的微辐照的处理计划。这 SARRP将集成到耶鲁癌症中心辐射器核心，其专业用途也将是 由PI和咨询委员会监督。该工具将支持几个正在进行的NIH资助 癌症生物学研究项目，增强实验设计并改善数据分析和 解释。 SARRP将如何增加正在进行的研究的示例很容易获得。萨尔普 将改善大脑中的目标定位，耶鲁大学许多项目以及其他项目进行了调查 解剖站点。它将实现几位寻求复制的调查人员的放射外科手术 每个分数方案的临床方案具有较高的辐射剂量。它还将提供研究的能力 辐射与正常组织和免疫系统的相互作用，并评估治疗反应 照射后的局部，区域和远处。使用SARRP引导辐射输送也是 期望招募新用户，为学员提供这项技术的教育经验，以及 显着扩大了肿瘤生物学和辐射科学的研究。