"Small Animal Radiation Research Platform (SARRP) for Yale University".

项目总结： 我们机构的研究人员使用了翻译啮齿动物模型来检查辐射对 自1955年以来，肿瘤和正常组织。今天，我们的辐射研究主要集中在致敏肿瘤上。 通过引入新的小分子、抗体、免疫学或遗传疗法来进行放射治疗。 然而，标准的正压输送设备不能概括临床放射治疗方案。他们 不提供剂量传递的准确性或同质性、不连续病变或器官的靶向、 正常组织，或对了解组织暴露至关重要的剂量-体积计算。小的 动物辐射研究平台(SARRP)-200 PRO解决了这些限制，并实现了基于目标的 使用集成锥束CT扫描(CBCT)和图像引导微照射的治疗计划。这个 SARRP将被整合到耶鲁癌症中心的辐射器核心中，其专门用途也将是 由私家侦探和一个顾问委员会监督。该工具将支持几个正在进行的NIH资助的项目 癌症生物学研究项目，改进实验设计，改进数据分析和 释义。SARRP将如何加强正在进行的研究的例子随处可见。SARRP 将改善目标在大脑中的本地化，耶鲁大学的许多项目以及其他项目都在研究这个网站 解剖位置。它将使放射外科的交付成为可能，这是几名寻求复制的研究人员所需的 每部分方案辐射剂量较高的临床情景。它还将提供研究 辐射与正常组织和免疫系统的相互作用，并评估治疗反应 辐射后的本地、地区和远程地点。使用SARRP引导的辐射传递也是 预计将招募新用户，为学员提供这项技术的教育体验，以及 显著扩大肿瘤生物学和放射科学的研究。

PROJECT SUMMARY: Investigators at our institution have used translational rodent models to examine the effects of radiation on tumors and normal tissues since 1955. Today our radiation research is largely focused on sensitizing tumors to radiation therapy by introducing novel small molecule, antibody, immunologic, or genetic therapies. However, standard orthovoltage delivery devices are unable to recapitulate clinical radiation protocols. They do not provide accuracy or homogeneity of dose delivery, targeting of discrete lesions or organs, sparing of normal tissues, or the dose-volume calculations essential for understanding tissue exposures. The small animal radiation research platform (SARRP)-200 PRO addresses these limitations and enables target-based treatment planning using an integrated cone beam CT scan (CBCT) and image guided micro-irradiation. The SARRP will be integrated in to the Yale Cancer Center Irradiator Core and its specialized use will also be overseen by the PI and an advisory committee. The instrument will support several ongoing NIH funded research projects in cancer biology, enhance experimental designs, and improve data analysis and interpretation. Examples of how the SARRP will augment ongoing research are readily available. The SARRP will improve target localization within the brain, a site investigated by many projects at Yale, as well as other anatomic sites. It will enable delivery of radiosurgery, required by several investigators that seek to reproduce clinical scenarios with high radiation dose per fraction regimens. It will also provide the ability to study the interactions of radiation with normal tissue and the immune system, and to evaluate therapeutic responses at local, regional, and distant sites following irradiation. The use of SARRP guided radiation delivery is also anticipated to recruit new users, provide educational experience with this technology for trainees, and significantly expand research in tumor biology and the radiation sciences.