Collision of Alzheimers disease and COVID-19 pandemic in the United States: risks, outcomes, disparities and treatments
Collision of Alzheimers disease and COVID-19 pandemic in the United States: risks, outcomes, disparities and treatments
批准号:
10417884
负责人:
Pamela B Davis
金额:
$234.2万
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
未结题
起止时间:
2022-05-01 至 2025-04-30
关键词:
2019-nCoVAfrican American populationAgeAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAmericanAmericasCOVID-19COVID-19 pandemicCOVID-19 riskCOVID-19 survivorsCategoriesClinical TrialsCommunicable DiseasesComplexContractsDataDatabasesDevelopmentDiagnosisDirect CostsDiseaseElectronic Health RecordElementsEtiologyEvolutionFacilities and Administrative CostsFamily CaregiverFutureHandHealth PolicyHealthcare SystemsHispanic PopulationsIncidenceInflammationInvestigationKnowledgeMass VaccinationsMethodsNatureOutcomePatientsPost-Acute Sequelae of SARS-CoV-2 InfectionPublic HealthRiskSARS-CoV-2 infectionSurvivorsTNF geneTestingTherapeuticTherapeutic EffectTimeUnited StatesUpdateVariantVirus DiseasesWomanaging populationbasedisorder preventionexperimental studygender disparityimprovedinhibitorinsightmortalityneuroinflammationneuropsychiatric sequelae of COVID-19neuropsychiatryolder patientpandemic diseasepatient populationracial disparityreal time monitoringresponse
中文摘要
项目摘要
在这个名为“阿尔茨海默病和COVID-19大流行在美国的碰撞:
风险、结果、差异和治疗”,我们建议:1)检查患有以下疾病的患者的COVID-19风险:
阿尔茨海默氏病(AD),考虑种族和性别差异,并随着时间的推移跟踪其演变; 2)检查
在COVID-19幸存者中新发AD,考虑种族和性别差异,并跟踪这些变化
时间; 3)描述COVID-19的长程神经精神性急性后遗症(Neuro-PASC),
19名AD幸存者,考虑种族和性别差异,并随着时间的推移跟踪这些变化;以及4)
研究肿瘤坏死因子(TNF)阻滞剂对总死亡率和长期生存率的治疗作用
患有AD的COVID-19幸存者的Neuro-PASC。为了回答这些问题,我们将利用一个全国性的,真实的-
8000万名患者(480万名确诊患者)的去识别电子健康记录(EHR)的时间数据库
COVID-19病例)。我们的研究将主要集中在超过1700万年龄≥ 65岁的老年患者,包括
超过100万例COVID-19病例,265,818例确诊为AD患者,22,518例同时患有AD和AD
COVID-19和AD(截至2021年5月20日)。我们的研究将建立实时分析EHR的方法,
美国数千万脆弱的老龄人口在检查传染病和他们的
与现有的疾病,如AD的相互作用,这将使我们能够更好地准备,如果另一个
流行病袭击了我们。因此,这些研究的意义超出了手头的数据。
英文摘要
PROJECT SUMMARY
In this project titled “Collision of Alzheimer’s disease and COVID-19 pandemic in the United States:
risks, outcomes, disparities and treatments”, we propose to: 1) examine COVID-19 risk in patients with
Alzheimer’s disease (AD), consider racial and gender disparity, and follow its evolution over time; 2) examine
new onset of AD in COVID-19 survivors, consider racial and gender disparity, and follow these changes over
time; 3) characterize long-haul neuropsychiatric Post-Acute Sequelae of COVID-19 (Neuro-PASC) in COVID-
19 survivors with AD, consider racial and gender disparity, and follow these changes over time; and 4)
investigate therapeutic effects of Tumor Necrosis Factor (TNF) blockers on overall mortality and long-haul
Neuro-PASC in COVID-19 survivors with AD. To answer these questions, we will utilize a US nation-wide, real-
time database of de-identified electronic health records (EHRs) of 80 million patients (4.8 million confirmed
COVID-19 cases). Our study will primarily focus on over 17 million senior patients age ³ 65 years, including
more than 1 million COVID-19 cases, 265,818 patients diagnosed with AD, and 22,518 patients with both
COVID-19 and AD (as of May 20, 2021). Our study will establish methods for real-time analysis of EHRs of
vulnerable aging population of tens of millions across the USA in examining infectious diseases and their
interaction with existing disorders such as AD, which will allow us to be better prepared should another
pandemic overtake us. The significance of these studies therefore extends beyond the data at hand.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Characterize multifaceted interactions between COVID-19 and alcohol use disorder based on real-time analysis of electronic health records of 62 million adult patients
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批准号:10687823
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项目类别:
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资助金额:$36.23万
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财政年份:2021
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负责人:Pamela B Davis
-
依托单位:
Characterize multifaceted interactions between COVID-19 and alcohol use disorder based on real-time analysis of electronic health records of 62 million adult patients
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批准号:10377762
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项目类别:
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资助金额:$36.23万
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财政年份:2021
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负责人:Pamela B Davis
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依托单位:
Characterize multifaceted interactions between COVID-19 and alcohol use disorder based on real-time analysis of electronic health records of 62 million adult patients
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批准号:10491155
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项目类别:
-
资助金额:$36.23万
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财政年份:2021
-
负责人:Pamela B Davis
-
依托单位:
CTSA INFRASTRUCTURE FOR CLINICAL TRIALS
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批准号:8366088
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项目类别:
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资助金额:$419.91万
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财政年份:2011
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负责人:Pamela B Davis
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依托单位:
CTSA INFRASTRUCTURE FOR AIDS RESEARCH
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批准号:8366086
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项目类别:
-
资助金额:$169.96万
-
财政年份:2011
-
负责人:Pamela B Davis
-
依托单位:
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCH
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批准号:8366087
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项目类别:
-
资助金额:$139.97万
-
财政年份:2011
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负责人:Pamela B Davis
-
依托单位:
CTSA INFRASTRUCTURE FOR AIDS RESEARCH
-
批准号:8366090
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项目类别:
-
资助金额:$169.96万
-
财政年份:2011
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负责人:Pamela B Davis
-
依托单位:
CASE WESTERN RESERVE UNIVERSITY/CLEVELAND CLINIC CTSA
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批准号:8366089
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项目类别:
-
资助金额:$233.28万
-
财政年份:2011
-
负责人:Pamela B Davis
-
依托单位:
CTSA INFRASTRUCTURE FOR CLINICAL TRIALS
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批准号:8173797
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项目类别:
-
资助金额:$428.07万
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财政年份:2010
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负责人:Pamela B Davis
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依托单位:
CTSA INFRASTRUCTURE FOR AIDS RESEARCH
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批准号:8173795
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项目类别:
-
资助金额:$160.53万
-
财政年份:2010
-
负责人:Pamela B Davis
-
依托单位:
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCH
-
批准号:8173796
-
项目类别:
-
资助金额:$214.03万
-
财政年份:2010
-
负责人:Pamela B Davis
-
依托单位:
CTSA INFRASTRUCTURE FOR AIDS RESEARCH
-
批准号:8173799
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项目类别:
-
资助金额:$160.53万
-
财政年份:2010
-
负责人:Pamela B Davis
-
依托单位:
CASE WESTERN RESERVE UNIVERSITY/CLEVELAND CLINIC CTSA
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批准号:8173798
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项目类别:
-
资助金额:$107.02万
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财政年份:2010
-
负责人:Pamela B Davis
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依托单位:
Case Western Researve Clinical and Translational Science Institute (UL1)
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批准号:7901706
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项目类别:
-
资助金额:$97.88万
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财政年份:2009
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负责人:Pamela B Davis
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依托单位:
Nucleolin-mediated cell entry of DNA nanoparticles
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批准号:7849651
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项目类别:
-
资助金额:$23.55万
-
财政年份:2009
-
负责人:Pamela B Davis
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依托单位:
CASE WESTERN RESERVE UNIVERSITY/CLEVELAND CLINIC CTSA (UL1): BPCA
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批准号:7961847
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项目类别:
-
资助金额:$47.8万
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财政年份:2009
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负责人:Pamela B Davis
-
依托单位:
Nucleolin-mediated cell entry of DNA nanoparticles
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批准号:7701310
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项目类别:
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资助金额:$19.63万
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财政年份:2009
-
负责人:Pamela B Davis
-
依托单位:
CASE WESTERN RESERVE UNIVERSITY/CLEVELAND CLINIC CTSA (UL1): BPCA
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批准号:7961848
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项目类别:
-
资助金额:$49.2万
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财政年份:2009
-
负责人:Pamela B Davis
-
依托单位:
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCH
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批准号:7719785
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项目类别:
-
资助金额:$210.03万
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财政年份:2008
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负责人:Pamela B Davis
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依托单位:
CASE WESTERN RESERVE UNIVERSITY/CLEVELAND CLINIC CTSA
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批准号:7719787
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项目类别:
-
资助金额:$420.04万
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财政年份:2008
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负责人:Pamela B Davis
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依托单位:
海外基金