Collision of Alzheimers disease and COVID-19 pandemic in the United States: risks, outcomes, disparities and treatments

项目总结 在这个名为“阿尔茨海默氏症与新冠肺炎在美国的碰撞”的项目中： 风险、结果、差异和治疗“，我们建议：1)检查慢性阻塞性肺疾病患者的新冠肺炎风险 阿尔茨海默病(AD)，考虑种族和性别差异，并跟踪其随时间的演变；2)检查 新冠肺炎幸存者中新发AD，考虑种族和性别差异，并跟踪这些变化 时间；3)新冠肺炎的远程神经精神后遗症(Neuro-PASC)的特征- 19名阿尔茨海默病幸存者，考虑种族和性别差异，并跟踪这些随时间的变化；以及4) 肿瘤坏死因子阻滞剂对总死亡率和远期疗效的研究 新冠肺炎阿尔茨海默病幸存者的神经-PASC。为了回答这些问题，我们将利用美国全国范围内真正的- 8000万名患者的未识别电子健康记录(EHR)的时间数据库(480万已确认 新冠肺炎案件)。我们的研究将主要集中在超过1700万名65岁的老年患者，包括 100多万新冠肺炎患者中，265,818名患者被诊断为AD，22,518名患者同时患有AD和AD 新冠肺炎和AD(截至2021年5月20日)。我们的研究将建立实时分析EHR的方法 美国数以千万计的脆弱老龄化人口在检查传染病及其 与AD等现有疾病的相互作用，这将使我们能够更好地为应对另一种疾病做好准备 大流行侵袭了我们。因此，这些研究的意义超越了手头的数据。

PROJECT SUMMARY In this project titled “Collision of Alzheimer’s disease and COVID-19 pandemic in the United States: risks, outcomes, disparities and treatments”, we propose to: 1) examine COVID-19 risk in patients with Alzheimer’s disease (AD), consider racial and gender disparity, and follow its evolution over time; 2) examine new onset of AD in COVID-19 survivors, consider racial and gender disparity, and follow these changes over time; 3) characterize long-haul neuropsychiatric Post-Acute Sequelae of COVID-19 (Neuro-PASC) in COVID- 19 survivors with AD, consider racial and gender disparity, and follow these changes over time; and 4) investigate therapeutic effects of Tumor Necrosis Factor (TNF) blockers on overall mortality and long-haul Neuro-PASC in COVID-19 survivors with AD. To answer these questions, we will utilize a US nation-wide, real- time database of de-identified electronic health records (EHRs) of 80 million patients (4.8 million confirmed COVID-19 cases). Our study will primarily focus on over 17 million senior patients age ³ 65 years, including more than 1 million COVID-19 cases, 265,818 patients diagnosed with AD, and 22,518 patients with both COVID-19 and AD (as of May 20, 2021). Our study will establish methods for real-time analysis of EHRs of vulnerable aging population of tens of millions across the USA in examining infectious diseases and their interaction with existing disorders such as AD, which will allow us to be better prepared should another pandemic overtake us. The significance of these studies therefore extends beyond the data at hand.