Characterize multifaceted interactions between COVID-19 and alcohol use disorder based on real-time analysis of electronic health records of 62 million adult patients

项目摘要 在疫情期间，由于社会孤立和悲伤，酒精消费量正在增加。SARS-CoV-2 它本身对中枢神经系统有很大的影响。当两个如此重要的公共卫生威胁 由于它们相互交叉，因此必须了解它们之间的相互作用和潜在的协同作用。在这个名为“表征 基于实时分析的COVID-19和酒精使用障碍之间的多方面相互作用 6200万成年患者的电子健康记录”，我们建议：1）表征对 酒精使用障碍（AUD）患者的COVID-19（“AUD → COVID-19”），考虑种族和性别 差异，并跟踪其随时间的演变; 2）描述COVID-19感染和社会流行病如何 背景影响澳元风险（“COVID-19加上大流行背景→澳元”），考虑种族和性别 差异，并随着时间的推移跟踪这些变化;和3）表征主要精神疾病的患病率， AUD和COVID-19患者的其他物质使用障碍和严重结局 （“AUD+COVID-19 →结果”），并随时间推移跟踪这些结果。我们的研究将确定潜在的 及时采取干预措施以保护患者或减轻COVID-19大流行和澳元的最坏影响的领域， 单独和组合。如果病毒变种再次激增，或者 AUD患者的疫苗犹豫性更大。如果我们有另一场大流行，它也将为此类研究提供信息 与另一种有机体，我们在这些研究中使用全国范围的数据库， 电子健康记录可以为快速、实时的分析和结果铺平道路，以告知我们的控制 措施

PROJECT SUMMARY During the pandemic, with social isolation and grief as drivers, alcohol consumption is increasing. SARS-CoV-2 itself has substantial impact on the central nervous system. When two such important public health menaces intersect, it is crucial to understand their interaction and potential synergy. In this project titled “Characterize multifaceted interactions between COVID-19 and alcohol use disorder based on real-time analysis of electronic health records of 62 million adult patients”, we propose to: 1) characterize susceptibility to COVID-19 in patients with alcohol use disorder (AUD) (“AUD → COVID-19”), consider racial and gender disparity, and follow its evolution over time; 2) characterize how COVID-19 infection and the social pandemic context impact the risk of AUD (“COVID-19 plus pandemic context → AUD”), consider racial and gender disparity, and follow these changes over time; and 3) characterize prevalence of major psychiatric disorders, other substance use disorders and severe outcomes among patients with both AUD and COVID-19 (“AUD+COVID-19 → outcomes”) and to follow these outcomes over time. Our studies will identify potential areas for timely interventions to protect patients or mitigate the worst effects of COVID-19 pandemic and AUD, singly and combined. This is especially important if there should be another surge with a virus variant, or if vaccine hesitancy is greater in those with AUD. It will also inform such studies if we have another pandemic with another organism, for the approaches we pioneer in these studies using nation-wide database of electronic health records may pave the way for rapid, real-time analytics and results to inform our control measures.