Characterize multifaceted interactions between COVID-19 and alcohol use disorder based on real-time analysis of electronic health records of 62 million adult patients

项目总结 在大流行期间，由于社会孤立和悲伤是驱动因素，酒精消费正在增加。SARS-CoV-2 它本身对中枢神经系统有重大影响。当两个如此重要的公共卫生威胁 因此，了解它们之间的相互作用和潜在的协同作用是至关重要的。在这个名为“特色化”的项目中 基于新冠肺炎与酒精使用障碍多方面互动的实时分析 6,200万成人患者的电子健康记录“，我们建议：1)表征对 新冠肺炎中的酒精使用障碍患者(“澳大利亚→新冠肺炎”)，考虑种族和性别 差异，并跟踪其随时间的演变；2)表征新冠肺炎感染和社会流行病 背景影响澳元病的风险(“新冠肺炎+大流行背景→澳元”)，考虑种族和性别 差异，并随着时间的推移跟踪这些变化；以及3)主要精神疾病的流行特征， 同时患有AUD和新冠肺炎患者的其他物质使用障碍和严重后果 (“澳元新冠肺炎→结果”)并随着时间的推移跟踪这些结果。我们的研究将确定潜在的 需要及时干预以保护患者或减轻新冠肺炎大流行和澳元病最严重影响的地区， 单独和组合。如果病毒变体出现另一次激增，或者如果 在患有AUD的人中，疫苗的犹豫程度更大。如果我们有另一场大流行，它也会通知这些研究 对于我们在这些研究中首创的方法，使用了全国范围的数据库 电子健康记录可能会为快速、实时的分析和结果铺平道路，以便为我们的控制提供信息 措施。

PROJECT SUMMARY During the pandemic, with social isolation and grief as drivers, alcohol consumption is increasing. SARS-CoV-2 itself has substantial impact on the central nervous system. When two such important public health menaces intersect, it is crucial to understand their interaction and potential synergy. In this project titled “Characterize multifaceted interactions between COVID-19 and alcohol use disorder based on real-time analysis of electronic health records of 62 million adult patients”, we propose to: 1) characterize susceptibility to COVID-19 in patients with alcohol use disorder (AUD) (“AUD → COVID-19”), consider racial and gender disparity, and follow its evolution over time; 2) characterize how COVID-19 infection and the social pandemic context impact the risk of AUD (“COVID-19 plus pandemic context → AUD”), consider racial and gender disparity, and follow these changes over time; and 3) characterize prevalence of major psychiatric disorders, other substance use disorders and severe outcomes among patients with both AUD and COVID-19 (“AUD+COVID-19 → outcomes”) and to follow these outcomes over time. Our studies will identify potential areas for timely interventions to protect patients or mitigate the worst effects of COVID-19 pandemic and AUD, singly and combined. This is especially important if there should be another surge with a virus variant, or if vaccine hesitancy is greater in those with AUD. It will also inform such studies if we have another pandemic with another organism, for the approaches we pioneer in these studies using nation-wide database of electronic health records may pave the way for rapid, real-time analytics and results to inform our control measures.