Characterize multifaceted interactions between COVID-19 and alcohol use disorder based on real-time analysis of electronic health records of 62 million adult patients

项目概要 疫情期间，由于社会孤立和悲伤，酒精消费量不断增加。 SARS-CoV-2 本身对中枢神经系统有重大影响。当两个如此重要的公共卫生威胁 交叉，了解它们的相互作用和潜在的协同作用至关重要。在这个名为“表征 基于实时分析的 COVID-19 和酒精使用障碍之间的多方面相互作用 6200 万成年患者的电子健康记录”，我们建议：1）描述对 酒精使用障碍 (AUD) 患者中的 COVID-19（“AUD → COVID-19”），考虑种族和性别 差异，并跟踪其随时间的演变； 2) 描述 COVID-19 感染和社会流行病的特征 背景影响 AUD 的风险（“COVID-19 加上大流行背景 → AUD”），考虑种族和性别 差异，并随着时间的推移跟踪这些变化； 3) 描述主要精神疾病的患病率， AUD 和 COVID-19 患者中的其他物质使用障碍和严重后果 （“AUD COVID-19→结果”）并随着时间的推移跟踪这些结果。我们的研究将确定潜在的 及时干预以保护患者或减轻 COVID-19 大流行和 AUD 最严重影响的领域， 单独和组合。如果病毒变种再次激增，或者如果 患有 AUD 的人对疫苗的犹豫程度更大。如果我们再次发生大流行，它也将为此类研究提供信息 与另一种生物体相比，我们在这些研究中采用的方法是使用全国范围的数据库 电子健康记录可能为快速、实时分析和结果铺平道路，以告知我们的控制 措施。

PROJECT SUMMARY During the pandemic, with social isolation and grief as drivers, alcohol consumption is increasing. SARS-CoV-2 itself has substantial impact on the central nervous system. When two such important public health menaces intersect, it is crucial to understand their interaction and potential synergy. In this project titled “Characterize multifaceted interactions between COVID-19 and alcohol use disorder based on real-time analysis of electronic health records of 62 million adult patients”, we propose to: 1) characterize susceptibility to COVID-19 in patients with alcohol use disorder (AUD) (“AUD → COVID-19”), consider racial and gender disparity, and follow its evolution over time; 2) characterize how COVID-19 infection and the social pandemic context impact the risk of AUD (“COVID-19 plus pandemic context → AUD”), consider racial and gender disparity, and follow these changes over time; and 3) characterize prevalence of major psychiatric disorders, other substance use disorders and severe outcomes among patients with both AUD and COVID-19 (“AUD+COVID-19 → outcomes”) and to follow these outcomes over time. Our studies will identify potential areas for timely interventions to protect patients or mitigate the worst effects of COVID-19 pandemic and AUD, singly and combined. This is especially important if there should be another surge with a virus variant, or if vaccine hesitancy is greater in those with AUD. It will also inform such studies if we have another pandemic with another organism, for the approaches we pioneer in these studies using nation-wide database of electronic health records may pave the way for rapid, real-time analytics and results to inform our control measures.