Integrative Analysis of Metabolic Phenotypes (IAMP) Predoctoral Training Program

项目摘要 宾夕法尼亚州立大学的“代谢表型综合分析（IAMP）博士前培训计划”将培养一个 未来一代的科学家在实验，分子和生物信息学方法应用于 整合了我们对健康和疾病中宿主代谢的理解。培训计划将建立在 建立了生物化学，生物学，分子，细胞和发育生物学的研究生课程， 营养科学、生物信息学和基因组学。该计划旨在培养未来的几代人， 实验学家在代谢，微生物学和生物物理/网络建模方面具有领先的专业知识， 解决代谢中的基本问题及其对宿主生理的影响。极其需要 为学员提供有关代谢，代谢组学和 微生物组，并训练他们使用新的和尖端的工具（例如，质谱法，核磁 共振光谱，下一代测序），以研究这些问题，在整个研究生培训 和未来的职业。拟议中的IAMP培训计划将培养一批多样化的年轻科学家， 生物化学、微生物学、营养科学、分子生物学、生物信息学和 统计数据，以解决宿主生理学中的基本问题和可能影响代谢的因素， 表型。该计划将在分子毒理学和致癌作用中心， 20多年来一直是合作者的焦点， 加上其他主要中心的额外捐款。培训计划将连接并进一步发展七个 建立研究生课程：生物化学，微生物学和分子生物学（BMMB），生物信息学和 基因组学（BG），生物学（BIOL），化学（CHEM），分子，细胞和综合生物科学（MCIBS）， 营养科学（NUTR）和病理生物学（PATAHOBIOL）。结合NIH和宾夕法尼亚州立大学的支持，IAMP 该项目计划在五年内培养至少19名博士预科生。每一位学员都将 在接受IAMP基础培训的同时，为他们两年的培训（第2年和第3年）提供支持。学员 对科学过程有足够的理解，在科学上有责任感，在前沿领域流利。 代谢组学平台和技术，利用数据集成方法的能力，以及 跨学科团队的沟通和领导能力。

PROJECT SUMMARY The Penn State `Integrative Analysis of Metabolic Phenotypes (IAMP) Predoctoral Training Program' will train a future generation of scientists in experimental, molecular, and bioinformatics approaches applied towards integrating our understanding of the host metabolism in health and disease. The training program will build upon established graduate programs in biochemistry, biology, molecular, cellular and developmental biology, nutritional science, bioinformatics and genomics. The program is designed to train future generations of experimentalists with a leading expertise in metabolism, microbiology, and biophysical/network modeling in addressing fundamental questions in metabolism and its impact on host physiology. There is a tremendous need to provide trainees with the fundamental knowledge pertaining to metabolism, metabolomics, and the microbiome and train them in the use of novel and cutting-edge tools (e.g., mass spectrometry, nuclear magnetic resonance spectroscopy, next generation sequencing) to study these issues throughout their graduate training and future careers. The proposed IAMP training program will train a diverse cohort of young scientists to have critical expertise in biochemistry, microbiology, nutritional science, molecular biology, bioinformatics and statistics to address fundamental questions in host physiology and factors that may influence the metabolic phenotype. The program will be anchored within the Center for Molecular Toxicology and Carcinogenesis, which has been a focal point for collaborators for more than 20 years and the newly formed Penn State Cancer Institute with additional contributions from other key centers. The training program will connect and further develop seven established graduate programs: Biochemistry, Microbiology and Molecular Biology (BMMB), Bioinformatics and Genomics (BG), Biology (BIOL), Chemistry (CHEM), Molecular, Cellular and Integrative Biosciences (MCIBS), Nutritional Sciences (NUTR), and Pathobiology (PATAHOBIOL). Combining NIH and Penn State support, IAMP program plans to train a minimum of 19 predoctoral students over a period of five years. Each trainee will be supported for the two years of their training (year 2 and 3) while receiving foundational training in IAMP. Trainees will gain enough understanding of the scientific process, responsible conduct in science, fluency in cutting edge metabolomic platforms and technologies, ability to utilize data integration approaches, and excellence in communication and leadership in cross disciplinary teams.