Integrative Analysis of Metabolic Phenotypes (IAMP) Predoctoral Training Program

代谢表型综合分析（IAMP）博士前培训项目

• 批准号: 10626745
• 负责人: Andrew Patterson
• 金额: $ 19.72万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10626745
• 关键词: Training Programs; metabolic phenotype; pre-doctoral

PROJECT SUMMARY The Penn State `Integrative Analysis of Metabolic Phenotypes (IAMP) Predoctoral Training Program' will train a future generation of scientists in experimental, molecular, and bioinformatics approaches applied towards integrating our understanding of the host metabolism in health and disease. The training program will build upon established graduate programs in biochemistry, biology, molecular, cellular and developmental biology, nutritional science, bioinformatics and genomics. The program is designed to train future generations of experimentalists with a leading expertise in metabolism, microbiology, and biophysical/network modeling in addressing fundamental questions in metabolism and its impact on host physiology. There is a tremendous need to provide trainees with the fundamental knowledge pertaining to metabolism, metabolomics, and the microbiome and train them in the use of novel and cutting-edge tools (e.g., mass spectrometry, nuclear magnetic resonance spectroscopy, next generation sequencing) to study these issues throughout their graduate training and future careers. The proposed IAMP training program will train a diverse cohort of young scientists to have critical expertise in biochemistry, microbiology, nutritional science, molecular biology, bioinformatics and statistics to address fundamental questions in host physiology and factors that may influence the metabolic phenotype. The program will be anchored within the Center for Molecular Toxicology and Carcinogenesis, which has been a focal point for collaborators for more than 20 years and the newly formed Penn State Cancer Institute with additional contributions from other key centers. The training program will connect and further develop seven established graduate programs: Biochemistry, Microbiology and Molecular Biology (BMMB), Bioinformatics and Genomics (BG), Biology (BIOL), Chemistry (CHEM), Molecular, Cellular and Integrative Biosciences (MCIBS), Nutritional Sciences (NUTR), and Pathobiology (PATAHOBIOL). Combining NIH and Penn State support, IAMP program plans to train a minimum of 19 predoctoral students over a period of five years. Each trainee will be supported for the two years of their training (year 2 and 3) while receiving foundational training in IAMP. Trainees will gain enough understanding of the scientific process, responsible conduct in science, fluency in cutting edge metabolomic platforms and technologies, ability to utilize data integration approaches, and excellence in communication and leadership in cross disciplinary teams.

项目总结 宾夕法尼亚州立大学“代谢表型综合分析(IAMP)博士前培训计划”将培训一名 未来一代科学家在实验、分子和生物信息学方法方面应用于 整合我们对健康和疾病中宿主新陈代谢的理解。培训计划将建立在 生物化学、生物学、分子、细胞和发育生物学的研究生课程， 营养科学、生物信息学和基因组学。该计划旨在培训未来几代 在新陈代谢、微生物学和生物物理/网络建模方面拥有领先专业知识的实验人员 阐述新陈代谢中的基本问题及其对寄主生理的影响。有一个巨大的需求 为学员提供有关新陈代谢、代谢组学和 并培训他们使用新的和尖端的工具(例如，质谱仪、核磁 共振光谱学、下一代测序)在整个研究生培训期间研究这些问题 以及未来的职业生涯。拟议的iAMP培训计划将培训一批不同的年轻科学家，使他们拥有 在生物化学、微生物学、营养科学、分子生物学、生物信息学和 解决寄主生理学的基本问题和可能影响代谢的因素的统计学 表型。该计划将在分子毒理学和癌症发生中心内进行，该中心 20多年来一直是合作者的焦点，新成立的宾夕法尼亚州立癌症研究所 来自其他关键中心的额外捐款。该培训计划将连接并进一步发展七个 已建立的研究生课程：生物化学、微生物学和分子生物学(BMMB)、生物信息学和 基因组学(BG)、生物学(Biol)、化学(CHEM)、分子、细胞和综合生物科学(MCIBS)、 营养科学(Nutr)和病理生物学(PATAHOBIOL)。结合NIH和宾夕法尼亚州立大学的支持，IAMP 该项目计划在五年内培养至少19名博士前学生。每名实习生都将 在接受iAMP基础培训的同时，为他们的两年培训(二年级和三年级)提供支持。实习生 将对科学过程有足够的了解，在科学方面负责任，在前沿领域流利 代谢平台和技术，利用数据集成方法的能力，以及在 在跨学科团队中的沟通和领导能力。

项目成果

Refined fiber inulin promotes inflammation-associated colon tumorigenesis by modulating microbial succinate production.

• DOI: 10.1002/cnr2.1863
• 发表时间: 2023-11
• 期刊: Cancer reports (Hoboken, N.J.)
• 作者: Tian S;Paudel D;Hao F;Neupane R;Castro R;Patterson AD;Tiwari AK;Prabhu KS;Singh V
• 通讯作者: Singh V

Induction of AHR Signaling in Response to the Indolimine Class of Microbial Stress Metabolites.

• DOI: 10.3390/metabo13090985
• 发表时间: 2023-08-31
• 期刊: Metabolites
• 影响因子: 4.1
• 作者: Patel D;Murray IA;Dong F;Annalora AJ;Gowda K;Coslo DM;Krzeminski J;Koo I;Hao F;Amin SG;Marcus CB;Patterson AD;Perdew GH
• 通讯作者: Perdew GH

The mitochondrion of Plasmodium falciparum is required for cellular acetyl-CoA metabolism and protein acetylation.

• DOI: 10.1073/pnas.2210929120
• 发表时间: 2023-04-25
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1

Menopausal stage differences in endothelial resistance to ischemia-reperfusion injury.

内皮抗缺血再灌注损伤的绝经阶段差异。

• DOI: 10.14814/phy2.15768
• 发表时间: 2023-09
• 期刊: Physiological reports
• 影响因子: 2.5

A Cross-Sectional Study of Dairy Cattle Metagenomes Reveals Increased Antimicrobial Resistance in Animals Farmed in a Heavy Metal Contaminated Environment.

• DOI: 10.3389/fmicb.2020.590325
• 发表时间: 2020
• 期刊: Frontiers in microbiology
• 影响因子: 5.2
• 作者: Gaeta NC;Bean E;Miles AM;de Carvalho DUOG;Alemán MAR;Carvalho JS;Gregory L;Ganda E
• 通讯作者: Ganda E