Administrative Core

行政核心

• 批准号: 10420512
• 负责人: Michael S Diamond
• 金额: $ 50.8万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-02 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10420512
• 关键词: Achievement; Administrative Coordination; Advisory Committees; Animals; Antibodies; Antigens; B-Lymphocytes; Collaborations; Communication; Contracts; Data; Data Analyses; Data Management Resources; Data Set; Databases; Development; Ensure; Evaluation; Fostering; Funding; Goals; Guidelines; Human Resources; Individual; Information Dissemination; Infrastructure; Laboratories; Leadership; Machine Learning; National Institute of Allergy and Infectious Disease; Participant; Preparation; Process; Proteins; Quality Control; Reagent; Report (document); Reporting; Research; Research Activity; Research Personnel; Research Project Grants; Resource Sharing; Resources; Series; Site; Stream; Systems Integration; T cell response; T-Lymphocyte; Teleconferences; Time; United States National Institutes of Health; Vaccine Antigen; Vaccines; base; cohesion; collaborative environment; cross immunity; cross reactivity; data exchange; data management; data repository; data sharing; data standards; design; distributed data; experience; experimental study; immunogenicity; meetings; member; organizational structure; pandemic disease; programs; universal coronavirus vaccine; vector

SUMMARY – ADMINISTRATIVE CORE A A primary goal of the Administrative Core A is to ensure an interactive environment, exchange of reagents and data, and foster a cohesive relationship among PIs of the PPG. This is a critical function, as this proposal plans an extensively intertwined series of experiments using shared resources among multiple laboratories. Core A will provide the requisite infrastructure to achieve the overall research objectives of the PPG. Effective scientific management and coordination by the Administrative Core will provide direction, oversight, and quality control for each Project and Core's research activities, and will maximize collaboration and exchange from all participating groups. Clear scientific leadership and direct communication by the Administrative Core will ensure optimal and transparent utilization of resources that promotes productive long-term relationships. The Administrative Core will promulgate data sharing, integration of projects, and communication, which will leverage the expertise of each member of the PPG to expedite discovery and achievement of the research goals. Related to this goal, Core A will implement a distributed data management infrastructure that will provide for easy submission and access of project data by all PPG investigators and the timely sharing of validated datasets to relevant public data repositories. Members of Core A also will develop a machine learning approach to identifying optimal antigens for vaccine components based on functional readouts and correlates of cross-protection. The Administrative Core will achieve several of these goals by providing a coherent stream of communication, which will begin by establishing monthly meetings between Program participants under the guidance of the Program Director, with support of the Co-Director. These meetings will be held through video teleconference and will promote data exchange, evaluation of progress and planning as it relates to the goals of the program and aims of individual projects. The Administrative Core also will foster communication and organizational structure throughout the PPG in other ways. This will include preparation of financial reports and documents for the NIH. The Administrative Core also will have particular financial and infrastructural responsibilities particularly as it relates to oversight, compliance with NIH and federal guidelines, and shared activities among PPG members.

摘要 – 行政核心 A 行政核心 A 的主要目标是确保互动环境、信息交流 试剂和数据，并在 PPG 的 PI 之间建立有凝聚力的关系。这是一个关键函数， 因为该提案计划利用共享资源进行一系列广泛交织的实验 多个实验室。核心A将提供必要的基础设施来实现整体研究 PPG 的目标。行政核心有效的科学管理和协调 为每个项目和核心的研究活动提供指导、监督和质量控制，并将 最大限度地提高所有参与团体的协作和交流。明确的科学领导和直接 行政核心的沟通将确保资源的最佳和透明利用 促进富有成效的长期关系。行政核心将颁布数据共享、 项目整合和沟通，这将利用 PPG 每位成员的专业知识 加快发现和实现研究目标。与此目标相关，Core A 将实施 分布式数据管理基础设施，可轻松提交和访问项目 所有 PPG 研究人员的数据以及将经过验证的数据集及时共享到相关公共数据 存储库。 Core A 的成员还将开发一种机器学习方法来识别最佳的 基于功能读数和交叉保护相关性的疫苗成分抗原。这 管理核心将通过提供连贯的流程来实现其中几个目标 沟通，这将从在计划参与者之间建立每月会议开始 项目主任的指导和联合主任的支持。这些会议将举行 通过视频电话会议，将促进数据交换、进展评估和规划 与计划的目标和各个项目的目标相关。行政核心还将 以其他方式促进整个 PPG 的沟通和组织结构。这将包括 为 NIH 准备财务报告和文件。行政核心还将有 特定的财务和基础设施责任，特别是与监督、合规相关的责任 遵循 NIH 和联邦指导方针，并在 PPG 成员之间共享活动。