Administrative Core

行政核心

• 批准号: 10420512
• 负责人: Michael S Diamond
• 金额: $ 50.8万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-02 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10420512
• 关键词: Achievement; Administrative Coordination; Advisory Committees; Animals; Antibodies; Antigens; B-Lymphocytes; Collaborations; Communication; Contracts; Data; Data Analyses; Data Management Resources; Data Set; Databases; Development; Ensure; Evaluation; Fostering; Funding; Goals; Guidelines; Human Resources; Individual; Information Dissemination; Infrastructure; Laboratories; Leadership; Machine Learning; National Institute of Allergy and Infectious Disease; Participant; Preparation; Process; Proteins; Quality Control; Reagent; Report (document); Reporting; Research; Research Activity; Research Personnel; Research Project Grants; Resource Sharing; Resources; Series; Site; Stream; Systems Integration; T cell response; T-Lymphocyte; Teleconferences; Time; United States National Institutes of Health; Vaccine Antigen; Vaccines; base; cohesion; collaborative environment; cross immunity; cross reactivity; data exchange; data management; data repository; data sharing; data standards; design; distributed data; experience; experimental study; immunogenicity; meetings; member; organizational structure; pandemic disease; programs; universal coronavirus vaccine; vector

SUMMARY – ADMINISTRATIVE CORE A A primary goal of the Administrative Core A is to ensure an interactive environment, exchange of reagents and data, and foster a cohesive relationship among PIs of the PPG. This is a critical function, as this proposal plans an extensively intertwined series of experiments using shared resources among multiple laboratories. Core A will provide the requisite infrastructure to achieve the overall research objectives of the PPG. Effective scientific management and coordination by the Administrative Core will provide direction, oversight, and quality control for each Project and Core's research activities, and will maximize collaboration and exchange from all participating groups. Clear scientific leadership and direct communication by the Administrative Core will ensure optimal and transparent utilization of resources that promotes productive long-term relationships. The Administrative Core will promulgate data sharing, integration of projects, and communication, which will leverage the expertise of each member of the PPG to expedite discovery and achievement of the research goals. Related to this goal, Core A will implement a distributed data management infrastructure that will provide for easy submission and access of project data by all PPG investigators and the timely sharing of validated datasets to relevant public data repositories. Members of Core A also will develop a machine learning approach to identifying optimal antigens for vaccine components based on functional readouts and correlates of cross-protection. The Administrative Core will achieve several of these goals by providing a coherent stream of communication, which will begin by establishing monthly meetings between Program participants under the guidance of the Program Director, with support of the Co-Director. These meetings will be held through video teleconference and will promote data exchange, evaluation of progress and planning as it relates to the goals of the program and aims of individual projects. The Administrative Core also will foster communication and organizational structure throughout the PPG in other ways. This will include preparation of financial reports and documents for the NIH. The Administrative Core also will have particular financial and infrastructural responsibilities particularly as it relates to oversight, compliance with NIH and federal guidelines, and shared activities among PPG members.

摘要-管理核心A 行政核心A的一个主要目标是确保一个互动的环境，交流 试剂和数据，并培养PPG的绩效指标之间的紧密联系。这是一个关键的功能， 由于该提案计划使用以下共享资源进行广泛交织的一系列实验 多个实验室。核心A将提供必要的基础设施，以实现整体研究 PPG的目标。以行政核心意志进行有效的科学管理和协调 为每个项目和核心的研究活动提供指导、监督和质量控制，并将 最大限度地提高所有参与组的协作和交流。明确科学领导和指导 行政核心的沟通将确保最佳和透明地利用资源 这促进了富有成效的长期关系。行政核心将公布数据共享， 整合项目和沟通，这将利用PPG每个成员的专业知识 以加速发现和实现研究目标。与这一目标相关的核心A将实施 分布式数据管理基础设施，可轻松提交和访问项目 所有PPG调查员提供的数据以及及时将经过验证的数据集共享给相关公共数据 储存库。核心A的成员还将开发一种机器学习方法来确定最优 基于功能读数和交叉保护相关性的疫苗组件的抗原。这个 管理核心将通过提供连贯的 沟通，这将通过建立计划参与者之间的月度会议来开始 在联合主任的支持下，由项目主任提供指导。这些会议将举行 通过视频电话会议，并将促进数据交换、进度评估和规划 与计划的目标和个别项目的目标有关。行政核心也将 通过其他方式促进整个PPG的沟通和组织结构。这将包括 为国家卫生研究院准备财务报告和文件。行政核心还将拥有 具体的财务和基础设施责任，特别是与监督、合规 符合NIH和联邦指南，并在PPG成员之间分享活动。