Administrative Core

行政核心

• 批准号: 10420512
• 负责人: Michael S Diamond
• 金额: $ 50.8万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-02 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10420512
• 关键词: Achievement; Administrative Coordination; Advisory Committees; Animals; Antibodies; Antigens; B-Lymphocytes; Collaborations; Communication; Contracts; Data; Data Analyses; Data Management Resources; Data Set; Databases; Development; Ensure; Evaluation; Fostering; Funding; Goals; Guidelines; Human Resources; Individual; Information Dissemination; Infrastructure; Laboratories; Leadership; Machine Learning; National Institute of Allergy and Infectious Disease; Participant; Preparation; Process; Proteins; Quality Control; Reagent; Report (document); Reporting; Research; Research Activity; Research Personnel; Research Project Grants; Resource Sharing; Resources; Series; Site; Stream; Systems Integration; T cell response; T-Lymphocyte; Teleconferences; Time; United States National Institutes of Health; Vaccine Antigen; Vaccines; base; cohesion; collaborative environment; cross immunity; cross reactivity; data exchange; data management; data repository; data sharing; data standards; design; distributed data; experience; experimental study; immunogenicity; meetings; member; organizational structure; pandemic disease; programs; universal coronavirus vaccine; vector

SUMMARY – ADMINISTRATIVE CORE A A primary goal of the Administrative Core A is to ensure an interactive environment, exchange of reagents and data, and foster a cohesive relationship among PIs of the PPG. This is a critical function, as this proposal plans an extensively intertwined series of experiments using shared resources among multiple laboratories. Core A will provide the requisite infrastructure to achieve the overall research objectives of the PPG. Effective scientific management and coordination by the Administrative Core will provide direction, oversight, and quality control for each Project and Core's research activities, and will maximize collaboration and exchange from all participating groups. Clear scientific leadership and direct communication by the Administrative Core will ensure optimal and transparent utilization of resources that promotes productive long-term relationships. The Administrative Core will promulgate data sharing, integration of projects, and communication, which will leverage the expertise of each member of the PPG to expedite discovery and achievement of the research goals. Related to this goal, Core A will implement a distributed data management infrastructure that will provide for easy submission and access of project data by all PPG investigators and the timely sharing of validated datasets to relevant public data repositories. Members of Core A also will develop a machine learning approach to identifying optimal antigens for vaccine components based on functional readouts and correlates of cross-protection. The Administrative Core will achieve several of these goals by providing a coherent stream of communication, which will begin by establishing monthly meetings between Program participants under the guidance of the Program Director, with support of the Co-Director. These meetings will be held through video teleconference and will promote data exchange, evaluation of progress and planning as it relates to the goals of the program and aims of individual projects. The Administrative Core also will foster communication and organizational structure throughout the PPG in other ways. This will include preparation of financial reports and documents for the NIH. The Administrative Core also will have particular financial and infrastructural responsibilities particularly as it relates to oversight, compliance with NIH and federal guidelines, and shared activities among PPG members.

摘要 - 行政核心A 行政核心A的主要目标是确保交互环境，交换 试剂和数据，并在PPG的PI之间建立了凝聚力的关系。这是一个关键功能， 由于该提案计划使用共享资源在 多个实验室。核心A将提供必要的基础设施来实现总体研究 PPG的目标。行政核心的有效科学管理和协调将 为每个项目和Core的研究活动提供指导，监督和质量控制，并将 最大化所有参与小组的协作和交流。明确的科学领导和直接 行政核心的交流将确保资源的最佳和透明利用 这促进了产品的长期关系。行政核心将颁布数据共享， 项目和沟通的整合，这将利用PPG每个成员的专业知识 加快研究目标的发现和实现。与这个目标有关，核心A将实施 一个分布式数据管理基础架构，可以轻松提交和访问项目 所有PPG调查人员的数据以及及时共享已验证的数据集与相关公共数据 存储库。核心A的成员还将开发一种机器学习方法来识别最佳 疫苗成分的抗原基于功能读数和交叉保护的相关性。这 行政核心将通过提供连贯的流来实现这些目标中的几个 沟通，这将首先建立计划参与者之间的月度会议 计划主任的指导，在联合导演的支持下。这些会议将举行 通过视频电话会议，并将促进数据交换，评估进度和计划 与计划的目标和各个项目的目标有关。行政核心也将 以其他方式促进整个PPG的沟通和组织结构。这将包括 准备NIH的财务报告和文件。行政核心也将有 特定的财务和基础设施责任，特别是与监督，合规性有关 使用NIH和联邦准则，以及PPG成员之间的共同活动。