The Development and Evaluation of Pan-Coronavirus Vaccines

泛冠状病毒疫苗的研发与评价

基本信息

  • 批准号:
    10420511
  • 负责人:
  • 金额:
    $ 799.08万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-02 至 2025-08-31
  • 项目状态:
    未结题

项目摘要

Overall Summary Given the historical outbreaks of coronaviruses, coupled with the recent emergence of SARS- CoV-2 and the destabilizing consequence of COVID-19 on global health and economy, there is an urgent and critical need to develop new vaccines capable of broad protection against existing and future Sarbecoviruses and Merbecoviruses. This P01 program project (PPG) addresses the hypothesis that a combination of evolutionarily-designed and optimized B and T cell antigens can confer broad and protective immunity against Sarbecoviruses and Merbecoviruses that currently exist or could emerge from zoonotic reservoirs. The PPG integrates the work of eleven leading laboratories with records of collaboration that have expertise in coronavirus biology, viral pathogenesis, B and T cell immunity, vaccine development, animal challenge studies, structural biology, antibody structure and function, antigen design, and evolutionary analysis of viruses. All Projects and Cores plan interactive studies with the focused goal of designing optimized B and T cell antigens for incorporation in adenoviral (ChAd) and vesicular stomatitis virus (VSV) vectors to create mucosal and systemic vaccines that protect against infection and disease caused by a range of coronaviruses of potential concern. The PPG is served by a central Animal Challenge Core that performs vaccination and infection experiments in mice and hamsters and a central Administrative Core that streamlines data management and sharing, provides computational analysis for down-selection and scientific decision-making, and facilitates communication. Our proposal and antigen design program serves as a blueprint for possible product development with ChAd vaccines, VSV-based vaccines, or even with other platforms (e.g., mRNA vaccines, nanoparticles, etc.) not directly evaluated here. By the conclusion of our PPG, we envision generating at least one and likely multiple viral- vectored vaccine platforms that induce broad spectrum immunity to multiple coronaviruses of concern including human and zoonotic Sarbecoviruses and Merbecoviruses that could emerge in the future.
总体总结 鉴于历史上曾爆发过冠状病毒,再加上最近出现的 SARS, CoV-2 和 COVID-19 对全球健康和经济造成的不稳定后果, 迫切需要开发能够广泛保护现有疫苗的新疫苗 以及未来的 Sarbecoviruses 和 Merbecoviruses。此 P01 程序项目 (PPG) 地址 假设进化设计和优化的 B 细胞和 T 细胞的组合 抗原可以赋予针对 Sarbecoviruses 的广泛和保护性免疫力 目前存在或可能从人畜共患病宿主中出现的梅贝克病毒。 PPG 整合了 11 个领先实验室的工作以及具有专业知识的合作记录 冠状病毒生物学、病毒发病机制、B 和 T 细胞免疫、疫苗开发、动物 挑战研究、结构生物学、抗体结构和功能、抗原设计以及 病毒的进化分析。所有项目和核心都计划与重点关注的互动研究 设计优化的 B 和 T 细胞抗原以掺入腺病毒 (ChAd) 和 水疱性口炎病毒 (VSV) 载体可用于制造粘膜和全身疫苗,以保护 预防由一系列潜在问题的冠状病毒引起的感染和疾病。 PPG 由执行疫苗接种和感染的中央动物挑战核心提供服务 小鼠和仓鼠实验以及简化数据的中央管理核心 管理和共享,为下选择和科学提供计算分析 决策,促进沟通。我们的提案和抗原设计方案服务于 作为 ChAd 疫苗、基于 VSV 的疫苗或 即使使用此处未直接评估的其他平台(例如 mRNA 疫苗、纳米颗粒等)也是如此。 通过我们的 PPG 的结论,我们设想产生至少一种并且可能多种病毒- 载体疫苗平台可诱导对多种冠状病毒的广谱免疫 包括人类和人畜共患的 Sarbecoviruses 和 Merbecoviruses 可能出现在 未来。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Michael S Diamond其他文献

West Nile virus: crossing the blood-brain barrier
西尼罗河病毒:穿越血脑屏障
  • DOI:
    10.1038/nm1204-1294
  • 发表时间:
    2004-12-01
  • 期刊:
  • 影响因子:
    50.000
  • 作者:
    Michael S Diamond;Robyn S Klein
  • 通讯作者:
    Robyn S Klein
MDA5 and autoimmune disease
MDA5 与自身免疫性疾病
  • DOI:
    10.1038/ng.2959
  • 发表时间:
    2014-04-28
  • 期刊:
  • 影响因子:
    29.000
  • 作者:
    Jonathan J Miner;Michael S Diamond
  • 通讯作者:
    Michael S Diamond
Zika virus vaccines and monoclonal antibodies: a priority agenda for research and development
寨卡病毒疫苗和单克隆抗体:研发的优先议程
  • DOI:
    10.1016/s1473-3099(24)00750-3
  • 发表时间:
    2025-07-01
  • 期刊:
  • 影响因子:
    31.000
  • 作者:
    Julia T Ostrowsky;Leah C Katzelnick;Nigel Bourne;Alan D T Barrett;Stephen J Thomas;Michael S Diamond;David W C Beasley;Eva Harris;Annelies Wilder-Smith;Tabitha Leighton;Angela J Mehr;Nicolina M Moua;Angela K Ulrich;Ana Cehovin;Petra C Fay;Josephine P Golding;Kristine A Moore;Michael T Osterholm;Eve M Lackritz;Kristina M Adams Waldorf;Jurai Wongsawat
  • 通讯作者:
    Jurai Wongsawat

Michael S Diamond的其他文献

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{{ truncateString('Michael S Diamond', 18)}}的其他基金

Development of Viral Vaccines against Sarbecoviruses and Merbecoviruses
Sarbecoviruses和Merbecoviruses病毒疫苗的研制
  • 批准号:
    10420516
  • 财政年份:
    2022
  • 资助金额:
    $ 799.08万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10420512
  • 财政年份:
    2022
  • 资助金额:
    $ 799.08万
  • 项目类别:
LDLRAD3 Receptor Interaction with Venezuelan Equine Encephalitis Virus
LDLRAD3 受体与委内瑞拉马脑炎病毒的相互作用
  • 批准号:
    10435558
  • 财政年份:
    2021
  • 资助金额:
    $ 799.08万
  • 项目类别:
Gut Microbiota Modulation of Chikungunya Virus Infection and Pathogenesis
基孔肯雅病毒感染和发病机制的肠道微生物群调节
  • 批准号:
    10379327
  • 财政年份:
    2021
  • 资助金额:
    $ 799.08万
  • 项目类别:
LDLRAD3 Receptor Interaction with Venezuelan Equine Encephalitis Virus
LDLRAD3 受体与委内瑞拉马脑炎病毒的相互作用
  • 批准号:
    10314344
  • 财政年份:
    2021
  • 资助金额:
    $ 799.08万
  • 项目类别:
Gut Microbiota Modulation of Chikungunya Virus Infection and Pathogenesis
基孔肯雅病毒感染和发病机制的肠道微生物群调节
  • 批准号:
    10597063
  • 财政年份:
    2021
  • 资助金额:
    $ 799.08万
  • 项目类别:
LDLRAD3 Receptor Interaction with Venezuelan Equine Encephalitis Virus
LDLRAD3 受体与委内瑞拉马脑炎病毒的相互作用
  • 批准号:
    10661719
  • 财政年份:
    2021
  • 资助金额:
    $ 799.08万
  • 项目类别:
Systemic Neurotropic virus infection effects on GI Dysmotility
全身嗜神经病毒感染对胃肠道运动障碍的影响
  • 批准号:
    10190929
  • 财政年份:
    2020
  • 资助金额:
    $ 799.08万
  • 项目类别:
Systemic Neurotropic virus infection effects on GI Dysmotility
全身嗜神经病毒感染对胃肠道运动障碍的影响
  • 批准号:
    10611909
  • 财政年份:
    2020
  • 资助金额:
    $ 799.08万
  • 项目类别:
Systemic Neurotropic virus infection effects on GI Dysmotility
全身嗜神经病毒感染对胃肠道运动障碍的影响
  • 批准号:
    10396586
  • 财政年份:
    2020
  • 资助金额:
    $ 799.08万
  • 项目类别:

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