XtremeCT II high-resolution peripheral quantitative computed tomography (HR-pQCT) scanner

XtremeCT II 高分辨率外周定量计算机断层扫描 (HR-pQCT) 扫描仪

• 批准号: 10420213
• 负责人: Ashley Weaver
• 金额: $ 43.75万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-15 至 2024-05-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10420213
• 关键词: Address; Adult; Advisory Committees; Aging; Applications Grants; Architecture; Biological; Bone Density; Chronic Kidney Failure; Computed Tomography Scanners; Computer Models; Development; Diabetes Mellitus; Diet; Elderly; Exercise; Fostering; Fracture; Funding; Genomics; Health; Image Analysis; Imaging Device; Incidence; Injury; Institutes; Interdisciplinary Study; Intervention; Investigation; Leadership; Life Style; Longevity; Minor; Musculoskeletal; Outcome; Peripheral; Population Heterogeneity; Proteins; Radiation; Rehabilitation therapy; Research; Resolution; Role; Skeletal Muscle; Skeleton; System; Techniques; Technology; United States National Institutes of Health; Vehicle crash; Weight; Weight maintenance regimen; Weight-Bearing state; X-Ray Computed Tomography; age related; base; biomedical imaging; bone; bone health; bone imaging; bone loss; bone strength; comorbidity; cost effectiveness; ethnic diversity; forest; fracture risk; imaging modality; imaging program; insight; instrument; medical schools; novel; skeletal; success; treatment strategy

Project Abstract In this Shared Instrument Grant application, we are requesting funds to acquire an XtremeCT II High Resolution Peripheral Quantitative Computed Tomography (HR-pQCT) scanner. HR-pQCT is a non-invasive, low radiation approach for assessing compartment-specific volumetric bone mineral density (vBMD) and bone microarchitecture in the peripheral skeleton to estimate bone strength and fracture risk. Integration of this state- of-the-art skeletal imaging modality into the repertoire of biomedical imaging tools available at Wake Forest School of Medicine (WFSM) advances the initiatives of 18 NIH-funded centers, institutes, and departments; and bolsters collaborative efforts with several of our regional partners. Specifically, acquisition of HR-pQCT technology will allow the proposed major and minor user groups to: 1) better understand the effects of lifestyle- based strategies — such as weight-bearing exercise and a high protein diet — on skeletal health among older adults losing weight; 2) expand the investigation of the role of age-related biological changes in skeletal muscle on the decline in mobility to include interactions with bone; 3) demonstrate the potential of advanced image analyses techniques to augment histostructural outcomes; 4) provide insight into the genomic architecture of bone health to aid in the development of novel treatment strategies to mitigate bone loss in aging; 5) better capture musculoskeletal comorbidities among motor vehicle crash occupants, and understand their influence on injury incidence and rehabilitation success; 6) address important gaps on the effects of weight management interventions on the growing skeleton; 7) evaluate whether bone microarchitecture varies across ethnically diverse populations; 8) augment computational modeling strategies assessing change in bone health across the lifespan to include bone microarchitecture and strength; and 9) determine the timing of and extent to which intracortical bone loss occurs among adults with diabetes mellitus and chronic kidney disease. To promote cost effectiveness, encourage optimal sharing, and foster multidisciplinary collaborations, the HR-pQCT will be housed in the Translational Imaging Program Core at WFSM, where it will be overseen by qualified leadership, operational, and advisory committees in accordance with well-organized and self-sustaining administrative and financial plans. Ultimately, the addition of a HR-pQCT system will enable WFSM to engage in more multidisciplinary collaborations, compete more successfully for external research funding, and remain at the forefront of musculoskeletal research endeavors.

项目摘要 在此共享仪器拨款申请中，我们申请资金用于购买XtremeCT II High 分辨率外周定量计算机断层扫描（HR-pQCT）扫描仪。HR-pQCT是一种非侵入性， 低辐射方法用于评估特定室体积骨矿物质密度（vBMD）和骨 外周骨骼中的微结构来估计骨强度和骨折风险。这种状态的整合- 将最先进的骨骼成像模式纳入维克森林的生物医学成像工具库 医学院（WFSM）推进18个NIH资助的中心，研究所和部门的举措; 加强与我们几个区域伙伴的协作努力。具体而言，HR-pQCT的获取 技术将使拟议的主要和次要用户群体：1）更好地了解生活方式的影响- 基于策略-如负重运动和高蛋白饮食-对老年人骨骼健康的影响 成年人减肥; 2）扩大骨骼肌中与年龄相关的生物学变化的作用的研究 包括与骨的相互作用; 3）证明高级图像的潜力 分析技术，以增加组织结构的结果; 4）提供深入了解基因组结构， 骨健康，以帮助开发新的治疗策略，以减轻衰老中的骨丢失; 5）更好地 捕获机动车碰撞乘员中的肌肉骨骼共病，并了解其对 损伤发生率和康复成功率; 6）解决体重管理效果的重要差距 对生长中的骨骼进行干预; 7）评估骨骼微结构是否因种族而异 不同人群; 8）增加计算建模策略，评估整个人群的骨健康变化 寿命，包括骨微结构和强度;和9）确定的时间和程度， 皮质内骨丢失发生在患有糖尿病和慢性肾病的成年人中。提高成本 有效性，鼓励最佳共享，并促进多学科合作，HR-pQCT将 位于WFSM的翻译成像项目核心，由合格的领导层监督， 业务委员会和咨询委员会，按照组织良好和自我维持的行政和 财务计划。最终，HR-pQCT系统的增加将使WFSM能够参与更多 多学科合作，更成功地竞争外部研究资金，并留在 肌肉骨骼研究的前沿。