Effect of protein supplementation during weight loss on older adult bone health

减肥期间补充蛋白质对老年人骨骼健康的影响

• 批准号: 10534765
• 负责人: Ashley Weaver
• 金额: $ 13.3万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-15 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10534765
• 关键词: 3-Dimensional; Adipocytes; Adipose tissue; Affect; Aging; American; Ancillary Study; Animal Model; Applications Grants; Assessment tool; Attenuated; Award; Biomedical Engineering; Body Composition; Body Weight decreased; Body mass index; Bone Density; Bone Marrow; Bone structure; Carbohydrates; Classification; Clinical; Clinical Research; Clinical Trials; Complement; Conduct Clinical Trials; Consumption; Data; Development; Diagnostic; Diet; Dietary Proteins; Dual-Energy X-Ray Absorptiometry; Elderly; Elements; Engineering; Exercise; Femur; Fracture; Geriatrics; Gerontology; Hip region structure; Image; Infrastructure; Intervention; Knowledge; Lead; Measurement; Measures; Medical Imaging; Mentored Research Scientist Development Award; Mentors; Modeling; Musculoskeletal; Nutritional; Nutritional Science; Obesity; Osteoporosis; Osteoporosis prevention; Outcome; Overweight; Participant; Persons; Pharmacotherapy; Phase; Phenotype; Physical Function; Population; Protein-Restricted Diet; Proteins; Radiology Specialty; Randomized; Recommendation; Recommended Dietary Allowance; Recording of previous events; Regulation; Research; Research Personnel; Resources; Risk; Scanning; Supplementation; Techniques; Testing; Thick; Thinness; Training; Trauma; United States National Institutes of Health; Vertebral column; Weight; Woman; X-Ray Computed Tomography; adult obesity; bone; bone health; bone loss; bone mass; bone metabolism; bone preservation; bone quality; bone strength; career; design; experience; follow-up; forest; fracture risk; high risk; improved; innovation; medical schools; men; multidisciplinary; nutrition; osteoporosis with pathological fracture; osteoprotective; prevent; prognostic tool; protein intake; research and development; risk prediction; spine bone structure; tool; translational study; weight maintenance

Project Summary. Dr. Weaver seeks this K25 mentored training award to expand her bioengineering research background in medical imaging and finite element modeling of trauma towards pursuit of an independent research career focused on reducing osteoporosis and fracture in older adults. Weight loss poses an increased risk of bone loss and fracture in older adults. The proposed research will test the overall hypothesis that higher dietary protein intake during and following weight loss will attenuate bone loss in older adults with obesity. Guided by an accomplished multidisciplinary mentoring team with expertise in aging, clinical trials, bone metabolism, nutrition, and radiology, the PI will: (1) Develop knowledge of gerontology and geriatric medicine, (2) Acquire training in the design and execution of clinical trials, 3) Obtain in-depth knowledge on bone metabolism and structure, including the influence of nutrition and weight loss, and 4) Develop expertise in dual-energy computed tomography (CT) acquisition and post-processing to measure volumetric bone mineral density, cortical thickness, and bone marrow adipose tissue. Dr. Weaver's training and research will take place at Wake Forest School of Medicine which has a strong history of clinical research in aging and an exceptional radiology infrastructure. The partnership with her co-mentor at Rutgers within the Department of Nutritional Sciences will provide additional resources and expertise related to the nutritional regulation of bone metabolism. The proposed ancillary study to the ongoing clinical trial, UPLIFT: Utilizing Protein During Weight Loss to Impact Physical Function, will examine bone health over 6 months of active weight loss, followed by 12 months of weight maintenance. Musculoskeletal phenotypes will be compared in older adults with obesity randomized to either: (1) a lower protein diet for weight loss and follow-up, (2) a higher protein diet for weight loss only, or (3) a higher protein diet for weight loss and follow-up. The ancillary study expands the UPLIFT trial by adding dual-energy CT scans of the lumbar spine and proximal femur at baseline, 6 months, and 18 months to compare the influence of a higher versus lower protein intake on: vertebral and femoral trabecular volumetric bone mineral density and cortical thickness (Primary Aim), bone marrow adiposity which may alter the trabecular matrix and affect bone strength (Secondary Aim 1), and bone strength and fracture risk predicted with subject-specific finite element modeling (Secondary Aim 2). The study will test if a higher protein diet improves bone outcomes during active weight loss (evaluated at 6 months), and if maintaining higher protein intake during weight maintenance further preserves bone (evaluated at 18 months). The proposed training and research plan will launch Dr. Weaver's career as an independent investigator focused on applying bioengineering techniques to: 1) develop translational tools for fracture prediction, and 2) assess osteoprotective interventions in clinical trials—ultimately leading to improved diagnostics, prognostic tools, clinical recommendations, and therapies for preventing osteoporosis and fracture in older adults.

项目总结。韦弗博士寻求这个K25指导培训奖，以扩大她的生物工程研究

项目成果

Lumbar Spine Response of Computational Finite Element Models in Multidirectional Spaceflight Landing Conditions.

多向航天着陆条件下计算有限元模型的腰椎响应。

• DOI: 10.1115/1.4045401
• 发表时间: 2020
• 期刊: Journal of biomechanical engineering
• 作者: Ye,Xin;Jones,DerekA;Gaewsky,JamesP;Koya,Bharath;McNamara,KyleP;Saffarzadeh,Mona;Putnam,JacobB;Somers,JeffreyT;Gayzik,FScott;Stitzel,JoelD;Weaver,AshleyA
• 通讯作者: Weaver,AshleyA

Computed tomography assessment of pelvic bone density: Associations with age and pelvic fracture in motor vehicle crashes.

骨盆骨密度的计算机断层扫描评估：与年龄和机动车碰撞中骨盆骨折的关联。

• DOI: 10.1016/j.aap.2023.107291
• 发表时间: 2023
• 期刊: Accident; analysis and prevention
• 作者: Weaver,AshleyA;Ronning,IsaacN;Armstrong,William;Miller,AnnaN;Kiani,Bahram;ShaynMartin,R;Beavers,KristenM;Stitzel,JoelD
• 通讯作者: Stitzel,JoelD

Comparing rib cortical thickness measurements from computed tomography (CT) and Micro-CT.

比较计算机断层扫描 (CT) 和 Micro-CT 的肋骨皮质厚度测量结果。

• DOI: 10.1016/j.compbiomed.2019.103330
• 发表时间: 2019
• 期刊: Computers in biology and medicine
• 影响因子: 7.7
• 作者: Hostetler,ZacharyS;Stitzel,JoelD;Weaver,AshleyA
• 通讯作者: Weaver,AshleyA

Comparison of morphing techniques to develop subject-specific finite element models of vertebrae.

开发特定主题椎骨有限元模型的变形技术的比较。

• DOI: 10.1080/10255842.2022.2113994
• 发表时间: 2023
• 期刊: Computer methods in biomechanics and biomedical engineering
• 影响因子: 1.6
• 作者: Rubenstein,RafaelI;Lalwala,Mitesh;Devane,Karan;Koya,Bharath;Kiani,Bahram;Weaver,AshleyA
• 通讯作者: Weaver,AshleyA

Characterization of subcutaneous pelvic adipose tissue morphology and composition at the plane of the ASIS: A retrospective study of living subjects.

ASIS 平面皮下盆腔脂肪组织形态和成分的表征：对活体受试者的回顾性研究。

• DOI: 10.1080/15389588.2022.2133887
• 发表时间: 2022
• 期刊: Traffic injury prevention
• 影响因子: 2
• 作者: Moore,AustinM;Efobi,SamanthaM;Aira,Jazmine;Weaver,AshleyA;Lenchik,Leon;Hsu,Fang-Chi;Gayzik,FScott
• 通讯作者: Gayzik,FScott