Systems Immunology profiling of respiratory viral infections in vulnerable populations
易感人群呼吸道病毒感染的系统免疫学分析
基本信息
- 批准号:10420943
- 负责人:
- 金额:$ 228.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-03-29 至 2027-02-28
- 项目状态:未结题
- 来源:
- 关键词:2019-nCoVAcuteAdenovirusesAdultAffectAntibodiesAntigensAsthmaAtlasesAutoimmune DiseasesBiological AssayBiologyBloodBlood specimenCOVID-19 pandemicCellsCharacteristicsChildChildhoodChronicChronic DiseaseClinicalCoronavirusCytometryDataData AnalysesDiseaseEconomicsEpidemicEpithelialEthnic OriginEtiologyFamilyFlow CytometryFrequenciesFundingFutureGenerationsGeneticGenomicsGoalsHumanHypersensitivityImmuneImmune System DiseasesImmune responseImmunologyImmunophenotypingImmunosuppressionIndividualInfectionInflammatoryInterventionKineticsLeadMeasurementMedicalMeta-AnalysisMetapneumovirusMethodsMethylationModelingMolecularMorbidity - disease rateMucositisMucous MembraneMultiomic DataObesityOutcomePathogenesisPatientsPediatric cohortPersonsPhenotypeProteomeRaceResearchRespiratory MucosaRespiratory SystemRespiratory Tract InfectionsRespiratory syncytial virusRheumatoid ArthritisRhinovirusRiskSamplingSeveritiesSeverity of illnessSocioeconomic StatusStimulusSystemSystems BiologyTherapeuticUnited States National Institutes of HealthVaccinesViralViral Respiratory Tract InfectionVirusVirus DiseasesVulnerable Populationsatopybasebenefit sharingchronic inflammatory diseaseclinical riskcohortcomorbidityexperiencehigh dimensionalityhuman diseasein silicoinfection riskinfluenzavirusinsightmathematical modelmethylomemortalitymultidimensional datamultiple omicsnovelnovel therapeuticsparainfluenza viruspathogenpredict clinical outcomeprogramsproteogenomicsrespiratory infection virusrespiratory virusresponsesample collectionspatiotemporaltherapeutically effectivetranscriptometransmission processtreatment strategyvirus host interaction
项目摘要
SUMMARY/ABSTRACT – OVERALL
Acute respiratory viral infections (ARVI) are the most frequently occurring global illness producing significant
morbidity and mortality, particularly in vulnerable populations. Children suffer higher frequencies of ARVI and
often experience re-infections. Common chronic diseases of childhood, most notably asthma but also allergies
(atopy) and obesity, can predispose to increased severity of ARVI. Similarly, adults with chronic inflammatory
diseases or on immunosuppression suffer significant consequences from ARVI. Adults with rheumatoid arthritis
(RA) have an increased risk for infection and respiratory mucosal inflammation may contribute to autoimmune
disease severity. The goal of this research program is to understand the molecular and cellular immune
signatures of the vulnerable host response to ARVI to identify novel therapies and individuals at risk for clinical
complications. The program includes a detailed systems immunology assessment of acute and long-term
airway and adaptive systemic immune responses to naturally occurring ARVI. The first project will identify how
asthma, atopy, and obesity lead to maladaptive immune responses to ARVI in pediatric subjects. The second
project will examine host response to ARVI in adults with RA. RA is a disease provoked by environmental
stimuli like respiratory infections and RA patients have baseline immune differences. These projects are
complementary and synergistic by utilizing similar sample types and timing of sample collection, and common
clinical endpoints. The individual projects benefit from shared multi-omics approaches through a Genomics
Core for the sample processing and generation of airway host transcriptome, proteome, epithelial methylation,
and viral quantity and expression data, along with host genetics. There is also a shared Adaptive Phenotyping
Core for the generation of high dimensional cytometry data to broadly characterize immune cell phenotypes
and for detailed identification of antigen-specific cells. This will allow for direct comparisons to be made
between the adult and pediatric cohorts to identify common and divergent responses to ARVI. In the Overall,
the first Specific Aim is to determine similar and divergent host responses to ARVI considering the pediatric
allergy/asthma (Project 1) and adult RA (Project 2) cohorts. The second Specific Aim is to consider these host
responses in the context of other large publicly-funded studies of viral infection through meta-analyses. The
final Specific Aim will be to develop predictive spatiotemporal models of how mucosal and systemic immune
responses to ARVI influence clinical outcomes. Our research program will produce novel mechanistic insights
into the diversity and commonality of human immune responses to acute respiratory viruses and use cutting-
edge methods to identify potential therapies.
摘要/抽象-总体
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Matthew C. Altman其他文献
Asthma-associated variants induce IL33 differential expression through a novel regulatory region
哮喘相关变异通过新的调控区域诱导 IL33 差异表达
- DOI:
10.1101/2020.09.09.290098 - 发表时间:
2020 - 期刊:
- 影响因子:0
- 作者:
I. Aneas;D. Decker;C. Howard;Débora R. Sobreira;N. Sakabe;K. Blaine;Michelle M. Stein;C. Hrusch;L. Montefiori;J. Tena;K. Magnaye;Selene M. Clay;J. Gern;D. Jackson;Matthew C. Altman;E. Naureckas;D. Hogarth;S. White;J. Gómez;Nathan Schoetler;C. Ober;A. Sperling;Marcelo Araujo da Nóbrega - 通讯作者:
Marcelo Araujo da Nóbrega
Lipid Mediators in Aspirin-Exacerbated Respiratory Disease.
阿司匹林加剧的呼吸系统疾病中的脂质介质。
- DOI:
- 发表时间:
2016 - 期刊:
- 影响因子:2.6
- 作者:
A. Parker;Andrew G. Ayars;Matthew C. Altman;W. Henderson - 通讯作者:
W. Henderson
Genetic contributions to epigenetic-defined endotypes of allergic phenotypes in children
- DOI:
10.1016/j.ajhg.2025.05.006 - 发表时间:
2025-07-03 - 期刊:
- 影响因子:8.100
- 作者:
Emma E. Thompson;Xiaoyuan Zhong;Peter Carbonetto;Andréanne Morin;Jason Willwerscheid;Cynthia M. Visness;Leonard B. Bacharier;Meyer Kattan;George T. O’Connor;Katherine Rivera-Spoljaric;Robert A. Wood;Diane R. Gold;Gurjit K. Khurana Hershey;Christine C. Johnson;Rachel L. Miller;Christine M. Seroogy;Edward M. Zoratti;Peter J. Gergen;Albert M. Levin;Matthew C. Altman;Carole Ober - 通讯作者:
Carole Ober
Dysregulation of airway and systemic interferon responses promotes asthma exacerbations in urban children
气道和全身干扰素反应的失调促进城市儿童哮喘加重
- DOI:
10.1016/j.jaci.2024.12.1090 - 发表时间:
2025-05-01 - 期刊:
- 影响因子:11.200
- 作者:
Courtney L. Gaberino;Matthew C. Altman;Michelle A. Gill;Leonard B. Bacharier;Rebecca S. Gruchalla;George T. O’Connor;Rajesh Kumar;Gurjit K. Khurana Hershey;Meyer Kattan;Andrew H. Liu;Stephen J. Teach;Edward M. Zoratti;Patrice M. Becker;Alkis Togias;Cynthia Visness;James E. Gern;William W. Busse;Daniel J. Jackson - 通讯作者:
Daniel J. Jackson
Identification of bronchial epithelial genes associated with type 2 eosinophilic inflammation in asthma
哮喘中与2型嗜酸性粒细胞炎症相关的支气管上皮基因的鉴定
- DOI:
10.1016/j.jaci.2024.12.1089 - 发表时间:
2025-05-01 - 期刊:
- 影响因子:11.200
- 作者:
Stephane Esnault;Kimberly A. Dill-McFarland;Matthew C. Altman;Melissa A. Rosenkranz;Nizar N. Jarjour;William W. Busse - 通讯作者:
William W. Busse
Matthew C. Altman的其他文献
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{{ truncateString('Matthew C. Altman', 18)}}的其他基金
Systems Immunology profiling of respiratory viral infections in vulnerable populations
易感人群呼吸道病毒感染的系统免疫学分析
- 批准号:
10598116 - 财政年份:2022
- 资助金额:
$ 228.39万 - 项目类别:
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