Training future leaders at the chemistry-biology interface

在化学-生物学界面培训未来的领导者

• 批准号: 10418785
• 负责人: JEREMY BASKIN
• 金额: $ 41.63万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10418785
• 关键词: Biology; Chemistry; Future; Training

Abstract This proposal describes plans to continue a rigorous chemistry-biology interface (CBI) predoctoral training program that is student-centered and designed to provide trainees with core and cross training in chemistry and biological sciences, various abilities to push the frontier of biomedical research at the chemistry-biology interface, and the skills and awareness for diverse career paths. The program, which has been continuously funded by the NIH since 1996, also promotes interdisciplinary collaborative research across the Cornell campus. We request funds to support 10 predoctoral trainees. Each trainee will carry out his or her doctoral thesis research with one or more of 30 faculty mentors affiliated with seven participating units: Chemistry and Chemical Biology, Biological and Biomedical Sciences, Chemical and Biomolecular Engineering, Microbiology and Immunology, Biochemistry and Molecular Cell Biology, Plant Biology, and Nutritional Sciences. Participating faculty have well-funded research programs in chemistry with strong connections to biology or vice versa. Students undergo training in areas that are broadly distributed over chemistry (synthetic organic, bioorganic, bioinorganic, biophysical, natural products, X-ray crystallography, metabolomics, and proteomics) and biology (protein structure and function, enzymology, immunology, signal transduction, chemotaxis, cell biology, host/pathogen interactions, and genomics). The CBI program continues to successfully merge the cultures of chemistry and biology with effective didactic and programmatic initiatives, including the adaptation of evidence-based training strategies and mentor training. CBI trainees take a core set of rigorous courses in both chemistry and biology and undergo responsible conduct of research training as well as rigor and reproducibility training. Trainees attend seminars in their core disciplines, participate together with faculty in a CBI seminar program, and organize an annual CBI symposium that features speakers from diverse career sectors. In addition to research training, our CBI training program puts career awareness and transferable skills training front and center. We design our career awareness and transferable skills workshops to address gaps between career skills needed and skills developed in PhD training that are reported in the literature and obtained through large-scale surveys. We require a sabbatical internship (or employer site visits in special cases) to allow trainees to explore different career options first-hand. These career training activities are designed based on the eight principles of experiential learning. The CBI training activities are accessible to students who are not financially supported by the CBI program and thus have a larger impact on Cornell campus. The program continues to produce a high-caliber cohort of trainees, who are increasingly more diverse due to our continued recruitment efforts, with strong publication records and career outcomes without increasing the time to degree.

摘要 这项建议描述了计划继续严格的化学生物学接口（CBI）博士前培训 一个以学生为中心的计划，旨在为学员提供化学方面的核心和交叉培训， 生物科学，在化学-生物学界面推动生物医学研究前沿的各种能力， 以及不同职业道路的技能和意识。该方案一直得到联合国的资助， 自1996年以来，NIH还在康奈尔大学校园内促进跨学科的合作研究。我们要求 资助10名博士生。每位学员将与一位博士生一起进行博士论文研究。 或更多的30名教师导师隶属于七个参与单位：化学和化学生物学，生物 化学与生物分子工程，微生物学与免疫学，生物化学 分子细胞生物学、植物生物学和营养科学。参与的教师有充足的资金 与生物学有密切联系的化学研究项目，反之亦然。学生接受培训， 广泛分布在化学领域（合成有机，生物有机，生物无机，生物物理，自然 产品、X射线晶体学、代谢组学和蛋白质组学）和生物学（蛋白质结构和功能， 酶学、免疫学、信号转导、趋化性、细胞生物学、宿主/病原体相互作用，以及 基因组学）。CBI计划继续成功地将化学和生物学的文化融合在一起， 教学和方案举措，包括调整循证培训战略和导师 训练CBI学员参加化学和生物学方面的核心严格课程， 开展研究培训以及严格性和再现性培训。学员参加研讨会， 学科，与教师一起参加CBI研讨会计划，并组织年度CBI研讨会 演讲者来自不同的职业领域。除了研究培训，我们的CBI培训计划 将职业意识和可转移技能培训放在首位。我们设计我们的职业意识， 可转移技能研讨会，以解决所需职业技能和博士培训中开发的技能之间的差距 这是在文献中报道的，并通过大规模调查获得。我们需要休假实习 (or在特殊情况下，雇主实地考察），让学员亲身探索不同的职业选择。这些 职业培训活动是根据体验式学习的八项原则设计的。CBI培训 活动是访问的学生谁不是由CBI计划的财政支持，因此有较大的 对康奈尔大学校园的影响该计划继续培养出一批高素质的学员，他们是 由于我们持续的招聘努力，我们的出版记录和职业生涯越来越多样化 不增加时间的结果。