Training future leaders at the chemistry-biology interface

在化学-生物学界面培训未来的领导者

• 批准号: 10418785
• 负责人: JEREMY BASKIN
• 金额: $ 41.63万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10418785
• 关键词: Biology; Chemistry; Future; Training

Abstract This proposal describes plans to continue a rigorous chemistry-biology interface (CBI) predoctoral training program that is student-centered and designed to provide trainees with core and cross training in chemistry and biological sciences, various abilities to push the frontier of biomedical research at the chemistry-biology interface, and the skills and awareness for diverse career paths. The program, which has been continuously funded by the NIH since 1996, also promotes interdisciplinary collaborative research across the Cornell campus. We request funds to support 10 predoctoral trainees. Each trainee will carry out his or her doctoral thesis research with one or more of 30 faculty mentors affiliated with seven participating units: Chemistry and Chemical Biology, Biological and Biomedical Sciences, Chemical and Biomolecular Engineering, Microbiology and Immunology, Biochemistry and Molecular Cell Biology, Plant Biology, and Nutritional Sciences. Participating faculty have well-funded research programs in chemistry with strong connections to biology or vice versa. Students undergo training in areas that are broadly distributed over chemistry (synthetic organic, bioorganic, bioinorganic, biophysical, natural products, X-ray crystallography, metabolomics, and proteomics) and biology (protein structure and function, enzymology, immunology, signal transduction, chemotaxis, cell biology, host/pathogen interactions, and genomics). The CBI program continues to successfully merge the cultures of chemistry and biology with effective didactic and programmatic initiatives, including the adaptation of evidence-based training strategies and mentor training. CBI trainees take a core set of rigorous courses in both chemistry and biology and undergo responsible conduct of research training as well as rigor and reproducibility training. Trainees attend seminars in their core disciplines, participate together with faculty in a CBI seminar program, and organize an annual CBI symposium that features speakers from diverse career sectors. In addition to research training, our CBI training program puts career awareness and transferable skills training front and center. We design our career awareness and transferable skills workshops to address gaps between career skills needed and skills developed in PhD training that are reported in the literature and obtained through large-scale surveys. We require a sabbatical internship (or employer site visits in special cases) to allow trainees to explore different career options first-hand. These career training activities are designed based on the eight principles of experiential learning. The CBI training activities are accessible to students who are not financially supported by the CBI program and thus have a larger impact on Cornell campus. The program continues to produce a high-caliber cohort of trainees, who are increasingly more diverse due to our continued recruitment efforts, with strong publication records and career outcomes without increasing the time to degree.

摘要 本提案描述了继续进行严格的化学-生物接口(CBI)博士前培训的计划 以学生为中心的课程，旨在为学员提供核心和交叉的化学和 生物科学，在化学-生物界面上推动生物医学研究前沿的各种能力， 以及对不同职业道路的技能和意识。该项目一直由 自1996年以来，NIH还在康奈尔大学校园内促进跨学科协作研究。我们请求 资助10名博士后实习生。每一位实习生在完成博士论文研究时都要带一个 或30多名教师导师，隶属于七个参与单元：化学和化学生物学、生物 和生物医学、化学和生物分子工程、微生物学和免疫学、生物化学 以及分子细胞生物学、植物生物学和营养学。参与的教职员工有充足的资金 与生物学有很强联系的化学研究项目，反之亦然。学生接受培训 广泛分布于化学领域(合成有机、生物有机、生物无机、生物物理、天然 产品、X射线结晶学、代谢组学和蛋白质组学)和生物学(蛋白质结构和功能， 酶学、免疫学、信号转导、趋化性、细胞生物学、宿主/病原体相互作用以及 基因组学)。CBI计划继续成功地将化学和生物文化与有效的 指导性和方案倡议，包括调整循证培训战略和导师 训练。CBI学员参加了一套严格的化学和生物核心课程，并接受了负责的培训 进行研究培训以及严谨和可重复性培训。学员参加核心课程的研讨会 与教师一起参加CBI研讨会计划，并组织一年一度的CBI研讨会 其中有来自不同职业领域的演讲者。除了研究培训，我们的CBI培训计划 把职业意识和可转让技能培训放在首位和中心位置。我们设计了我们的职业意识和 可转移的技能研讨会，以解决所需的职业技能与博士培训中培养的技能之间的差距 这是文献中报道的，并通过大规模调查获得的。我们需要一个休假实习机会。 (或特殊情况下的雇主实地访问)，让学员第一手探索不同的职业选择。这些 职业培训活动是基于体验式学习的八项原则设计的。CBI培训 没有CBI计划经济支持的学生可以参加活动，因此有更大的 对康奈尔大学校园的影响。该计划继续培养一批高素质的实习生，他们是 由于我们不断的招聘努力，越来越多样化，拥有良好的出版记录和职业生涯 在不增加达到程度的时间的情况下获得结果。