Training future leaders at the chemistry-biology interface

在化学-生物学界面培训未来的领导者

• 批准号: 10623322
• 负责人: JEREMY BASKIN
• 金额: $ 42.44万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10623322
• 关键词: Biology; Chemistry; Future; Training

Abstract This proposal describes plans to continue a rigorous chemistry-biology interface (CBI) predoctoral training program that is student-centered and designed to provide trainees with core and cross training in chemistry and biological sciences, various abilities to push the frontier of biomedical research at the chemistry-biology interface, and the skills and awareness for diverse career paths. The program, which has been continuously funded by the NIH since 1996, also promotes interdisciplinary collaborative research across the Cornell campus. We request funds to support 10 predoctoral trainees. Each trainee will carry out his or her doctoral thesis research with one or more of 30 faculty mentors affiliated with seven participating units: Chemistry and Chemical Biology, Biological and Biomedical Sciences, Chemical and Biomolecular Engineering, Microbiology and Immunology, Biochemistry and Molecular Cell Biology, Plant Biology, and Nutritional Sciences. Participating faculty have well-funded research programs in chemistry with strong connections to biology or vice versa. Students undergo training in areas that are broadly distributed over chemistry (synthetic organic, bioorganic, bioinorganic, biophysical, natural products, X-ray crystallography, metabolomics, and proteomics) and biology (protein structure and function, enzymology, immunology, signal transduction, chemotaxis, cell biology, host/pathogen interactions, and genomics). The CBI program continues to successfully merge the cultures of chemistry and biology with effective didactic and programmatic initiatives, including the adaptation of evidence-based training strategies and mentor training. CBI trainees take a core set of rigorous courses in both chemistry and biology and undergo responsible conduct of research training as well as rigor and reproducibility training. Trainees attend seminars in their core disciplines, participate together with faculty in a CBI seminar program, and organize an annual CBI symposium that features speakers from diverse career sectors. In addition to research training, our CBI training program puts career awareness and transferable skills training front and center. We design our career awareness and transferable skills workshops to address gaps between career skills needed and skills developed in PhD training that are reported in the literature and obtained through large-scale surveys. We require a sabbatical internship (or employer site visits in special cases) to allow trainees to explore different career options first-hand. These career training activities are designed based on the eight principles of experiential learning. The CBI training activities are accessible to students who are not financially supported by the CBI program and thus have a larger impact on Cornell campus. The program continues to produce a high-caliber cohort of trainees, who are increasingly more diverse due to our continued recruitment efforts, with strong publication records and career outcomes without increasing the time to degree.

抽象的 该提案描述了继续严格的化学-生物学接口（CBI）博士前培训的计划 该计划以学生为中心，旨在为学员提供化学和化学方面的核心和交叉培训 生物科学，在化学-生物学界面推动生物医学研究前沿的各种能力， 以及多样化职业道路的技能和意识。该计划一直由 NIH 自 1996 年以来也在康奈尔大学校园内促进跨学科合作研究。我们要求 资助10名博士前培训生。每位学员将与一名博士生进行博士论文研究 7个参赛单位的30名或以上教师导师：化学与化学生物学、生物 和生物医学科学、化学和生物分子工程、微生物学和免疫学、生物化学 以及分子细胞生物学、植物生物学和营养科学。参与的教师资金雄厚 与生物学有密切联系的化学研究项目，反之亦然。学生接受培训 广泛分布于化学领域（合成有机、生物有机、生物无机、生物物理、天然 产品、X 射线晶体学、代谢组学和蛋白质组学）和生物学（蛋白质结构和功能、 酶学、免疫学、信号转导、趋化性、细胞生物学、宿主/病原体相互作用，以及 基因组学）。 CBI 项目继续成功地将化学和生物学文化与有效的 教学和计划举措，包括调整循证培训策略和导师 训练。 CBI 学员参加化学和生物学方面的一套严格的核心课程，并承担责任 进行研究培训以及严谨性和可重复性培训。学员参加核心研讨会 学科，与教师一起参加 CBI 研讨会计划，并组织年度 CBI 研讨会 演讲者来自不同的职业领域。除了研究培训之外，我们的 CBI 培训计划 将职业意识和可转移技能培训放在首位。我们设计我们的职业意识和 可转移技能研讨会，以解决所需的职业技能与博士培训中培养的技能之间的差距 文献中报道并通过大规模调查获得。我们需要休假实习 （或特殊情况下雇主实地考察）让学员亲身探索不同的职业选择。这些 职业培训活动是根据体验式学习的八项原则设计的。 CBI培训 没有 CBI 计划经济支持的学生也可以参加活动，因此有更大的机会 对康奈尔大学校园的影响该计划继续培养一批高素质的学员，他们 由于我们持续不断的招聘努力，我们的出版记录和职业生涯变得越来越多样化 在不增加达到学位时间的情况下获得结果。

项目成果

Discovering dynamic plant enzyme complexes in yeast for novel alkaloid pathway identification from a medicinal plant kratom.

在酵母中发现动态植物酶复合物，用于从药用植物卡痛叶中鉴定新的生物碱途径。

• DOI: 10.1101/2023.01.16.524293
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Wu,Yinan;Liu,Chang;Gong,FranklinL;Li,Sijin
• 通讯作者: Li,Sijin

Cardiac glycosides protect wormseed wallflower (Erysimum cheiranthoides) against some, but not all, glucosinolate-adapted herbivores.

强心苷可以保护蠕虫壁花（Erysimum cheiranthoides）免受某些但不是全部适应芥子油苷的食草动物的侵害。

• DOI: 10.1101/2023.09.19.558517
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Younkin,GordonC;Alani,MartinL;Capador,AnamaríaPáez;Fischer,HillaryD;Mirzaei,Mahdieh;Hastings,AmyP;Agrawal,AnuragA;Jander,Georg
• 通讯作者: Jander,Georg

MULTI-SCULPT: Multiplex Integration via Selective, CRISPR-Mediated, Ultralong Pathway Transformation in Yeast for Plant Natural Product Synthesis.

• DOI: 10.1021/acssynbio.2c00135
• 发表时间: 2022-07-15
• 期刊: ACS SYNTHETIC BIOLOGY
• 影响因子: 4.7
• 作者: Gong, Franklin Leyang;Han, Jianing;Li, Sijin
• 通讯作者: Li, Sijin

Ribosome Stalling of N-Linked Glycoproteins in Cell-Free Extracts.

• DOI: 10.1021/acssynbio.2c00311
• 发表时间: 2022-12-16
• 期刊: ACS SYNTHETIC BIOLOGY
• 影响因子: 4.7
• 作者: Chung, Sean S.;Bidstrup, Erik J.;Hershewe, Jasmine M.;Warfel, Katherine F.;Jewett, Michael C.;DeLisa, Matthew P.
• 通讯作者: DeLisa, Matthew P.

Leveraging yeast to characterize plant biosynthetic gene clusters.

• DOI: 10.1016/j.pbi.2022.102314
• 发表时间: 2023-02
• 期刊: CURRENT OPINION IN PLANT BIOLOGY
• 影响因子: 9.5
• 作者: Wu, Yinan;Gong, Franklin L.;Li, Sijin
• 通讯作者: Li, Sijin