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Training future leaders at the chemistry-biology interface

在化学-生物学界面培训未来的领导者

基本信息

批准号：
10623322
负责人：
JEREMY BASKIN
金额：
$ 42.44万
依托单位：
CORNELL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10623322
关键词：
Biology Chemistry Future Training

项目摘要

Abstract This proposal describes plans to continue a rigorous chemistry-biology interface (CBI) predoctoral training program that is student-centered and designed to provide trainees with core and cross training in chemistry and biological sciences, various abilities to push the frontier of biomedical research at the chemistry-biology interface, and the skills and awareness for diverse career paths. The program, which has been continuously funded by the NIH since 1996, also promotes interdisciplinary collaborative research across the Cornell campus. We request funds to support 10 predoctoral trainees. Each trainee will carry out his or her doctoral thesis research with one or more of 30 faculty mentors affiliated with seven participating units: Chemistry and Chemical Biology, Biological and Biomedical Sciences, Chemical and Biomolecular Engineering, Microbiology and Immunology, Biochemistry and Molecular Cell Biology, Plant Biology, and Nutritional Sciences. Participating faculty have well-funded research programs in chemistry with strong connections to biology or vice versa. Students undergo training in areas that are broadly distributed over chemistry (synthetic organic, bioorganic, bioinorganic, biophysical, natural products, X-ray crystallography, metabolomics, and proteomics) and biology (protein structure and function, enzymology, immunology, signal transduction, chemotaxis, cell biology, host/pathogen interactions, and genomics). The CBI program continues to successfully merge the cultures of chemistry and biology with effective didactic and programmatic initiatives, including the adaptation of evidence-based training strategies and mentor training. CBI trainees take a core set of rigorous courses in both chemistry and biology and undergo responsible conduct of research training as well as rigor and reproducibility training. Trainees attend seminars in their core disciplines, participate together with faculty in a CBI seminar program, and organize an annual CBI symposium that features speakers from diverse career sectors. In addition to research training, our CBI training program puts career awareness and transferable skills training front and center. We design our career awareness and transferable skills workshops to address gaps between career skills needed and skills developed in PhD training that are reported in the literature and obtained through large-scale surveys. We require a sabbatical internship (or employer site visits in special cases) to allow trainees to explore different career options first-hand. These career training activities are designed based on the eight principles of experiential learning. The CBI training activities are accessible to students who are not financially supported by the CBI program and thus have a larger impact on Cornell campus. The program continues to produce a high-caliber cohort of trainees, who are increasingly more diverse due to our continued recruitment efforts, with strong publication records and career outcomes without increasing the time to degree.

摘要

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Discovering dynamic plant enzyme complexes in yeast for novel alkaloid pathway identification from a medicinal plant kratom.

在酵母中发现动态植物酶复合物，用于从药用植物卡痛叶中鉴定新的生物碱途径。

DOI：
10.1101/2023.01.16.524293
发表时间：
2023
期刊：
bioRxiv : the preprint server for biology
影响因子：
0
作者：
Wu,Yinan;Liu,Chang;Gong,FranklinL;Li,Sijin
通讯作者：
Li,Sijin

Cardiac glycosides protect wormseed wallflower (Erysimum cheiranthoides) against some, but not all, glucosinolate-adapted herbivores.

强心苷可以保护蠕虫壁花（Erysimum cheiranthoides）免受某些但不是全部适应芥子油苷的食草动物的侵害。

DOI：
10.1101/2023.09.19.558517
发表时间：
2023
期刊：
bioRxiv : the preprint server for biology
影响因子：
0
作者：
Younkin,GordonC;Alani,MartinL;Capador,AnamaríaPáez;Fischer,HillaryD;Mirzaei,Mahdieh;Hastings,AmyP;Agrawal,AnuragA;Jander,Georg
通讯作者：
Jander,Georg

MULTI-SCULPT: Multiplex Integration via Selective, CRISPR-Mediated, Ultralong Pathway Transformation in Yeast for Plant Natural Product Synthesis.

DOI：
10.1021/acssynbio.2c00135
发表时间：
2022-07-15
期刊：
ACS SYNTHETIC BIOLOGY
影响因子：
4.7
作者：
Gong, Franklin Leyang;Han, Jianing;Li, Sijin
通讯作者：
Li, Sijin

Ribosome Stalling of N-Linked Glycoproteins in Cell-Free Extracts.

DOI：
10.1021/acssynbio.2c00311
发表时间：
2022-12-16
期刊：
ACS SYNTHETIC BIOLOGY
影响因子：
4.7
作者：
Chung, Sean S.;Bidstrup, Erik J.;Hershewe, Jasmine M.;Warfel, Katherine F.;Jewett, Michael C.;DeLisa, Matthew P.
通讯作者：
DeLisa, Matthew P.

Leveraging yeast to characterize plant biosynthetic gene clusters.