EpiCenter for Emerging Infectious Disease Intelligence

EpiCenter 新发传染病情报

基本信息

批准号：
10418755
负责人：
Christopher M Barker
金额：
$ 158.12万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-13 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10418755
关键词：
Acute Animals Arboviruses Area Chiroptera Clinic Collaborations Communicable Diseases Communities Congo Consensus Country Coupled Culicidae Detection Disease Disease Outbreaks Disease Surveillance Disease model Early Diagnosis Ecosystem Emerging Communicable Diseases Enrollment Ensure Entomology Epidemiology Ethics Event Evolution Fever Filovirus Goals Government Health Human Immunodiagnostics Infectious Disease Epidemiology Infectious Diseases Research Influenza Institution Intelligence International Investigation Medical Entomology Methods Microbiology Modeling Monitor National Institute of Allergy and Infectious Disease Pathogen detection Peripheral Persons Peru Pilot Projects RNA Viruses Readiness Recording of previous events Research Research Activity Research Priority Resources Rest Reverse Transcriptase Polymerase Chain Reaction Risk Scientist Security Serology Site Source Surveillance Program System Techniques Technology Testing Time Uganda Viral Virus Work Zoonoses acute infection base cohort cross-species transmission deep sequencing disease transmission disorder risk emerging infectious disease evolution epidemiological model experience forest global health high risk improved innovation insight multidisciplinary next generation nonhuman primate novel pandemic disease response tool transmission process urban setting vector vector-borne viral detection viral transmission virology vulnerable community zoonotic spillover

项目摘要

Project Summary/Abstract: The Epicenter for Emerging Infectious Disease Intelligence brings together a consortium of leading research institutions to advance an understanding of viral emergence from wildlife into humans living in forest and rapidly urbanizing ecosystems. Our work will enhance preparedness for disease emergence events in the Congo Basin and Amazon Basin forest regions and facilitate response efforts at the source of emergence. Our multidisciplinary team has internationally recognized expertise in infectious disease epidemiology, virology, human health, animal health, medical entomology, microbiology, and disease modeling. Our proposed activities integrate human, animal, and vector surveillance to enable insight into cross-species disease transmission and facilitate responsiveness to evolving needs that impact country, regional, and global emerging infectious disease risk. In our initial work, we propose to investigate the epidemiology of arboviruses and filoviruses, which include emerging viruses currently threatening global health security. We will evaluate disease transmission dynamics at the primary stage of emergence in humans, in forest communities where people are highly susceptible to virus spillover from wildlife and mosquitos. We will also investigate these viruses in the second stage of emergence, in urban centers peripherally connected to forests, where viruses have adapted to human-to-human transmission (by direct or vector-borne transmission). Targeted filoviruses and arboviruses at proposed sites in Uganda and Peru represent a range of emergence histories, from recent emergence events, to seasonal and annual re- emergence events, to introduction events where viruses have adapted to entirely new ecosystems, vectors, and vertebrate hosts. Research at these sites will advance our understanding of cross-species transmission for viruses across this spectrum of emergence. Our work will optimize best practices in acute febrile illness surveillance in high-risk communities coupled with wildlife and entomologic risk characterization studies to facilitate deployment of next generation techniques in early detection of virus emergence and monitoring of sustained transmission in at-risk communities. Our consortium has a demonstrated commitment to strengthening international capabilities for emerging infectious disease research in resource-limited countries. We are well- poised to contribute to important advances in capacity in the Amazon and Congo Basin forest region with partners in Uganda and Peru for completion of our proposed project and long-term sustainability for the greater region and across the Emerging Infectious Disease Research Center network.

项目摘要/摘要：新兴传染病智力的震中汇集了领先的研究联盟制度是为了促进从野生动植物进入森林中的人类的病毒出现的理解，并迅速城市化生态系统。我们的工作将增强刚果盆地疾病出现事件的准备亚马逊盆地森林地区，并促进了出现来源的反应努力。我们的多学科团队在传染病流行病学，病毒学，人类健康，动物方面具有国际认可的专业知识健康，医学昆虫学，微生物学和疾病建模。我们提议的活动将人类整合动物和矢量监视，以洞悉跨物种疾病的传播并促进对影响国家，地区和全球新兴传染病风险的不断发展的需求的响应能力。在我们最初的工作，我们建议调查Arbovires和Fileviruses的流行病学，其中包括当前威胁全球卫生安全的新兴病毒。我们将评估疾病传播动态在人类出现的主要阶段，在人们非常容易受到病毒影响的森林社区来自野生动植物和蚊子的溢出。我们还将在出现的第二阶段调查这些病毒，在城市中心与森林的外围连接，病毒已适应人类到人类传播（通过直接或矢量传播）。在乌干达和秘鲁代表着一系列出现历史，从最近的出现事件到季节性和年度重新出现事件，介绍病毒已适应全新的生态系统，向量和脊椎动物主机。这些站点的研究将提高我们对跨物种传播的理解在这种出现范围内的病毒。我们的工作将优化急性高温疾病的最佳实践高风险社区的监视以及野生动植物和昆虫学风险表征研究促进在早期发现病毒出现和监测的下一代技术高危社区的持续传播。我们的财团表现出致力于加强的承诺在资源有限的国家中，国际新兴疾病研究的国际能力。我们很好准备为亚马逊和刚果盆地森林地区的能力进步做出贡献乌干达和秘鲁的合作伙伴完成了我们提议的项目和长期可持续性的完成地区以及跨越新兴的传染病研究中心网络。