EpiCenter for Emerging Infectious Disease Intelligence

项目摘要/摘要： 新兴传染病情报中心汇集了一个领先研究联盟 机构推动对病毒从野生动物迅速进入生活在森林中的人类的了解 城市化的生态系统。我们的工作将加强刚果盆地出现疾病事件的准备工作 和亚马逊盆地林区，并促进在出现的源头作出反应的努力。我们的多学科 团队在传染病流行病学、病毒学、人类健康、动物方面拥有国际公认的专业知识 健康、医学昆虫学、微生物学和疾病模型。我们提议的活动将人类、 动物和病媒监测，以深入了解跨物种疾病传播并促进 对影响国家、地区和全球新发传染病风险的不断变化的需求的响应能力。在……里面 我们的初步工作是调查虫媒病毒和丝状病毒的流行病学，包括 目前威胁全球卫生安全的新出现病毒。我们将评估疾病传播动力学 在人类出现的初级阶段，在人们对病毒高度敏感的森林社区 野生动物和蚊子的溢出效应。我们还将在出现的第二阶段调查这些病毒， 在与森林相连的城市中心，病毒已经适应了人与人之间的传播 (通过直接或媒介传播)。乌干达拟议地点的目标丝状病毒和虫媒病毒以及 秘鲁代表了一系列的涌现历史，从最近的涌现事件到季节性和年度的重新出现。 出现事件，到引入事件，病毒已经适应了全新的生态系统、媒介和 脊椎动物的宿主。在这些地点的研究将促进我们对跨物种传播的理解 病毒横跨这一新出现的光谱。我们的工作将优化急性发热性疾病的最佳实践 结合野生动物和昆虫学风险表征研究对高危社区进行监测 促进部署下一代技术，以及早检测病毒出现和监测 在高危社区持续传播。我们的财团已证明致力于加强 资源有限国家新发传染病研究的国际能力。我们很好- 准备为亚马逊和刚果盆地林区能力的重要进展做出贡献 乌干达和秘鲁的合作伙伴完成我们提议的项目并实现更大的长期可持续性 区域和新发传染病研究中心网络。

Project Summary/Abstract: The Epicenter for Emerging Infectious Disease Intelligence brings together a consortium of leading research institutions to advance an understanding of viral emergence from wildlife into humans living in forest and rapidly urbanizing ecosystems. Our work will enhance preparedness for disease emergence events in the Congo Basin and Amazon Basin forest regions and facilitate response efforts at the source of emergence. Our multidisciplinary team has internationally recognized expertise in infectious disease epidemiology, virology, human health, animal health, medical entomology, microbiology, and disease modeling. Our proposed activities integrate human, animal, and vector surveillance to enable insight into cross-species disease transmission and facilitate responsiveness to evolving needs that impact country, regional, and global emerging infectious disease risk. In our initial work, we propose to investigate the epidemiology of arboviruses and filoviruses, which include emerging viruses currently threatening global health security. We will evaluate disease transmission dynamics at the primary stage of emergence in humans, in forest communities where people are highly susceptible to virus spillover from wildlife and mosquitos. We will also investigate these viruses in the second stage of emergence, in urban centers peripherally connected to forests, where viruses have adapted to human-to-human transmission (by direct or vector-borne transmission). Targeted filoviruses and arboviruses at proposed sites in Uganda and Peru represent a range of emergence histories, from recent emergence events, to seasonal and annual re- emergence events, to introduction events where viruses have adapted to entirely new ecosystems, vectors, and vertebrate hosts. Research at these sites will advance our understanding of cross-species transmission for viruses across this spectrum of emergence. Our work will optimize best practices in acute febrile illness surveillance in high-risk communities coupled with wildlife and entomologic risk characterization studies to facilitate deployment of next generation techniques in early detection of virus emergence and monitoring of sustained transmission in at-risk communities. Our consortium has a demonstrated commitment to strengthening international capabilities for emerging infectious disease research in resource-limited countries. We are well- poised to contribute to important advances in capacity in the Amazon and Congo Basin forest region with partners in Uganda and Peru for completion of our proposed project and long-term sustainability for the greater region and across the Emerging Infectious Disease Research Center network.