EpiCenter for Emerging Infectious Disease Intelligence

EpiCenter 新发传染病情报

• 批准号: 10633155
• 负责人: Christopher M Barker
• 金额: $ 155.53万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-13 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10633155
• 关键词: Acute; Animals; Arboviruses; Area; Chiroptera; Clinic; Collaborations; Communicable Diseases; Communities; Congo; Consensus; Country; Coupled; Culicidae; Detection; Disease; Disease Outbreaks; Disease Surveillance; Disease model; Early Diagnosis; Ecosystem; Emerging Communicable Diseases; Enrollment; Ensure; Epidemiology; Ethics; Event; Evolution; Fever; Filovirus; Goals; Government; Health; Human; Immunodiagnostics; Infectious Disease Epidemiology; Infectious Diseases Research; Influenza; Institution; Intelligence; International; Investigation; Medical Entomology; Methods; Microbiology; Modeling; Monitor; National Institute of Allergy and Infectious Disease; Pathogen detection; Peripheral; Persons; Peru; Pilot Projects; Predisposition; RNA Viruses; Readiness; Recording of previous events; Research; Research Activity; Research Priority; Resources; Rest; Reverse Transcriptase Polymerase Chain Reaction; Risk; Scientist; Seasons; Security; Serology; Site; Source; Surveillance Program; System; Techniques; Technology; Testing; Time; Uganda; Urbanization; Viral; Virus; Work; Zoonoses; acute infection; cohort; cross-species transmission; deep sequencing; disease transmission; disorder risk; emerging infectious disease evolution; epidemiological model; experience; forest; global health; high risk; improved; innovation; insight; integration site; multidisciplinary; new pandemic; next generation; nonhuman primate; novel; outbreak concern; outbreak preparedness; outbreak response; pandemic potential; response; tool; transmission process; urban setting; vector; vector-borne; viral detection; viral transmission; virology; vulnerable community; zoonotic spillover

Project Summary/Abstract: The Epicenter for Emerging Infectious Disease Intelligence brings together a consortium of leading research institutions to advance an understanding of viral emergence from wildlife into humans living in forest and rapidly urbanizing ecosystems. Our work will enhance preparedness for disease emergence events in the Congo Basin and Amazon Basin forest regions and facilitate response efforts at the source of emergence. Our multidisciplinary team has internationally recognized expertise in infectious disease epidemiology, virology, human health, animal health, medical entomology, microbiology, and disease modeling. Our proposed activities integrate human, animal, and vector surveillance to enable insight into cross-species disease transmission and facilitate responsiveness to evolving needs that impact country, regional, and global emerging infectious disease risk. In our initial work, we propose to investigate the epidemiology of arboviruses and filoviruses, which include emerging viruses currently threatening global health security. We will evaluate disease transmission dynamics at the primary stage of emergence in humans, in forest communities where people are highly susceptible to virus spillover from wildlife and mosquitos. We will also investigate these viruses in the second stage of emergence, in urban centers peripherally connected to forests, where viruses have adapted to human-to-human transmission (by direct or vector-borne transmission). Targeted filoviruses and arboviruses at proposed sites in Uganda and Peru represent a range of emergence histories, from recent emergence events, to seasonal and annual re- emergence events, to introduction events where viruses have adapted to entirely new ecosystems, vectors, and vertebrate hosts. Research at these sites will advance our understanding of cross-species transmission for viruses across this spectrum of emergence. Our work will optimize best practices in acute febrile illness surveillance in high-risk communities coupled with wildlife and entomologic risk characterization studies to facilitate deployment of next generation techniques in early detection of virus emergence and monitoring of sustained transmission in at-risk communities. Our consortium has a demonstrated commitment to strengthening international capabilities for emerging infectious disease research in resource-limited countries. We are well- poised to contribute to important advances in capacity in the Amazon and Congo Basin forest region with partners in Uganda and Peru for completion of our proposed project and long-term sustainability for the greater region and across the Emerging Infectious Disease Research Center network.

项目概要/摘要： 新兴传染病情报中心汇集了一个领先的研究联盟 机构，以促进了解病毒出现从野生动物到人类生活在森林和迅速 城市化生态系统。我们的工作将加强对刚果盆地疾病突发事件的准备 和亚马逊流域森林地区，并促进在出现源头的应对工作。我们的多学科 团队拥有国际公认的传染病流行病学，病毒学，人类健康，动物 健康、医学昆虫学、微生物学和疾病建模。我们提出的活动将人类， 动物和病媒监测，以便深入了解跨物种疾病传播， 应对影响国家、区域和全球新发传染病风险的不断变化的需求。在 我们的初步工作是调查虫媒病毒和丝状病毒的流行病学，其中包括 新出现的病毒正在威胁全球卫生安全。我们将评估疾病传播动力学 在人类出现的初级阶段，在人们对病毒高度敏感的森林社区， 野生动物和蚊子的传播。我们还将调查这些病毒出现的第二阶段， 在与森林相连的城市中心，病毒已经适应了人与人之间的传播 (by直接或媒介传播）。在乌干达的拟议地点针对丝状病毒和虫媒病毒， 秘鲁代表了一系列的出现历史，从最近的出现事件，到季节性和年度性的重新出现， 出现事件，到病毒适应全新生态系统、媒介的引入事件， 脊椎动物宿主在这些地点的研究将促进我们对跨物种传播的理解， 出现的各种病毒。我们的工作将优化急性发热性疾病的最佳实践 在高风险社区进行监测，并结合野生动物和昆虫风险特征研究， 促进部署新一代技术，以便及早发现病毒出现和监测 在高危社区持续传播。我们的联合体已表明致力于加强 在资源有限的国家开展新出现的传染病研究的国际能力。我们很好- 准备为亚马逊和刚果盆地森林地区的能力取得重要进展做出贡献， 乌干达和秘鲁的合作伙伴，以完成我们的拟议项目和长期可持续性，为更大的 地区和整个新兴传染病研究中心网络。