EpiCenter for Emerging Infectious Disease Intelligence

EpiCenter 新发传染病情报

• 批准号: 10864210
• 负责人: Christopher M Barker
• 金额: $ 39.89万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-13 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10864210
• 关键词: Acute; Animals; Arboviruses; Area; Chiroptera; Clinic; Collaborations; Communicable Diseases; Communities; Congo; Consensus; Country; Coupled; Culicidae; Detection; Disease; Disease Outbreaks; Disease Surveillance; Disease model; Early Diagnosis; Ecosystem; Emerging Communicable Diseases; Enrollment; Ensure; Epidemiology; Ethics; Event; Evolution; Fever; Filovirus; Goals; Government; Health; Human; Immunodiagnostics; Infectious Disease Epidemiology; Infectious Diseases Research; Influenza; Institution; Intelligence; International; Investigation; Medical Entomology; Methods; Microbiology; Modeling; Monitor; National Institute of Allergy and Infectious Disease; Pathogen detection; Peripheral; Persons; Peru; Pilot Projects; Predisposition; RNA Viruses; Readiness; Recording of previous events; Research; Research Activity; Research Priority; Resources; Rest; Reverse Transcriptase Polymerase Chain Reaction; Risk; Scientist; Seasons; Security; Serology; Site; Source; Surveillance Program; System; Techniques; Technology; Testing; Time; Uganda; Urbanization; Viral; Virus; Work; Zoonoses; acute infection; cohort; cross-species transmission; deep sequencing; disease transmission; disorder risk; emerging infectious disease evolution; epidemiological model; experience; forest; global health; high risk; improved; innovation; insight; integration site; multidisciplinary; new pandemic; next generation; nonhuman primate; novel; outbreak concern; outbreak preparedness; outbreak response; pandemic potential; response; tool; transmission process; urban setting; vector; vector-borne; viral detection; viral transmission; virology; vulnerable community; zoonotic spillover

Project Summary/Abstract: The Epicenter for Emerging Infectious Disease Intelligence brings together a consortium of leading research institutions to advance an understanding of viral emergence from wildlife into humans living in forest and rapidly urbanizing ecosystems. Our work will enhance preparedness for disease emergence events in the Congo Basin and Amazon Basin forest regions and facilitate response efforts at the source of emergence. Our multidisciplinary team has internationally recognized expertise in infectious disease epidemiology, virology, human health, animal health, medical entomology, microbiology, and disease modeling. Our proposed activities integrate human, animal, and vector surveillance to enable insight into cross-species disease transmission and facilitate responsiveness to evolving needs that impact country, regional, and global emerging infectious disease risk. In our initial work, we propose to investigate the epidemiology of arboviruses and filoviruses, which include emerging viruses currently threatening global health security. We will evaluate disease transmission dynamics at the primary stage of emergence in humans, in forest communities where people are highly susceptible to virus spillover from wildlife and mosquitos. We will also investigate these viruses in the second stage of emergence, in urban centers peripherally connected to forests, where viruses have adapted to human-to-human transmission (by direct or vector-borne transmission). Targeted filoviruses and arboviruses at proposed sites in Uganda and Peru represent a range of emergence histories, from recent emergence events, to seasonal and annual re- emergence events, to introduction events where viruses have adapted to entirely new ecosystems, vectors, and vertebrate hosts. Research at these sites will advance our understanding of cross-species transmission for viruses across this spectrum of emergence. Our work will optimize best practices in acute febrile illness surveillance in high-risk communities coupled with wildlife and entomologic risk characterization studies to facilitate deployment of next generation techniques in early detection of virus emergence and monitoring of sustained transmission in at-risk communities. Our consortium has a demonstrated commitment to strengthening international capabilities for emerging infectious disease research in resource-limited countries. We are well- poised to contribute to important advances in capacity in the Amazon and Congo Basin forest region with partners in Uganda and Peru for completion of our proposed project and long-term sustainability for the greater region and across the Emerging Infectious Disease Research Center network.

项目摘要/摘要： 新兴传染病情报中心汇集了领先研究联盟 机构，以增进对病毒从野生动物到生活在森林中的人类的了解并迅速传播 城市化生态系统。我们的工作将加强对刚果盆地疾病出现事件的准备 和亚马逊流域森林地区，并促进在出现源头的应对工作。我们的多学科 团队在传染病流行病学、病毒学、人类健康、动物 健康、医学昆虫学、微生物学和疾病建模。我们提议的活动将人类、 动物和媒介监测，以深入了解跨物种疾病传播并促进 对影响国家、区域和全球新发传染病风险的不断变化的需求的响应。在 在我们的初步工作中，我们建议调查虫媒病毒和丝状病毒的流行病学，其中包括 当前，新出现的病毒威胁着全球健康安全。我们将评估疾病传播动态 在人类出现的初级阶段，在人们极易感染病毒的森林群落中 野生动物和蚊子的溢出。我们还将在出现的第二阶段研究这些病毒， 在与森林相连的城市中心，病毒已经适应了人与人之间的传播 （通过直接或媒介传播）。乌干达和阿布扎比拟定地点的丝状病毒和虫媒病毒的目标 秘鲁代表了一系列的出现历史，从最近的出现事件，到季节性和年度重新出现 出现事件，到病毒适应全新生态系统、媒介和的引入事件 脊椎动物宿主。这些地点的研究将增进我们对跨物种传播的理解 跨越这一范围的病毒的出现。我们的工作将优化急性发热性疾病的最佳实践 高风险社区的监测以及野生动物和昆虫学风险特征研究 促进下一代技术的部署，以早期检测病毒出现和监测 在高危社区持续传播。我们的财团明确致力于加强 资源有限国家新发传染病研究的国际能力。我们很好- 准备为亚马逊和刚果盆地森林地区的能力重大进步做出贡献 乌干达和秘鲁的合作伙伴完成我们拟议的项目并实现长期可持续发展 地区和整个新发传染病研究中心网络。

项目成果

Molecular Characterization by Multilocus Sequence Typing and Diversity Analysis of Rickettsia asembonensis in Peru.

通过多头骨序列分型和秘鲁人力苯甲状腺的多样性分析的分子表征。

• DOI: 10.1089/vbz.2021.0077
• 发表时间: 2022-03
• 期刊: Vector borne and zoonotic diseases (Larchmont, N.Y.)
• 作者: Loyola S;Torre A;Flores-Mendoza C;Kocher C;Salmon-Mulanovich G;Richards AL;Leguia M
• 通讯作者: Leguia M

Direct mosquito feedings on dengue-2 virus-infected people reveal dynamics of human infectiousness.

• DOI: 10.1371/journal.pntd.0011593
• 发表时间: 2023-09
• 期刊: PLoS neglected tropical diseases
• 影响因子: 3.8

The impact of sustained malaria control in the Loreto region of Peru: a retrospective, observational, spatially-varying interrupted time series analysis of the PAMAFRO program.

• DOI: 10.1016/j.lana.2023.100477
• 发表时间: 2023-04
• 期刊: LANCET REGIONAL HEALTH-AMERICAS
• 作者: Janko, Mark M.;Recalde-Coronel, G. Cristina;Damasceno, Camila P.;Salmon-Mulanovich, Gabriela;Barbieri, Alisson F.;Lescano, Andres G.;Zaitchik, Benjamin F.;Pan, William K.
• 通讯作者: Pan, William K.

Sylvatic Transmission of Chikungunya Virus among Nonhuman Primates in Myanmar.

基孔肯雅病毒在缅甸非人类灵长类动物中的森林传播。

• DOI: 10.3201/eid2812.220893
• 发表时间: 2022-12
• 期刊: Emerging infectious diseases
• 影响因子: 11.8

Highly pathogenic avian influenza A (H5N1) in marine mammals and seabirds in Peru.

• DOI: 10.1038/s41467-023-41182-0
• 发表时间: 2023-09-07
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Leguia, Mariana;Garcia-Glaessner, Alejandra;Munoz-Saavedra, Breno;Juarez, Diana;Barrera, Patricia;Calvo-Mac, Carlos;Jara, Javier;Silva, Walter;Ploog, Karl;Amaro, Lady;Colchao-Claux, Paulo;Johnson, Christine K.;Uhart, Marcela M.;Nelson, Martha I.;Lescano, Jesus
• 通讯作者: Lescano, Jesus