Postdoctoral Training, Neurobiology of Aging and Alzheimer's Disease

博士后培训，衰老和阿尔茨海默病的神经生物学

• 批准号: 10419557
• 负责人: CAROL A. BARNES
• 金额: $ 22.92万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10419557
• 关键词: Aging; Alzheimer' s Disease; Neurobiology; post-doctoral training

Project Summary/Abstract The postdoctoral training grant entitled “The Neurobiology of Aging and Alzheimer's Disease” is submitted through the University of Arizona on behalf of the Arizona Alzheimer's Consortium. The training faculty chosen from the Consortium consist of highly interactive investigators whose scientific interests include aging, Alzheimer's disease (AD) and AD-related dementias (ADRD) and spans fly, rodent, and nonhuman primate models of aging, as well as human studies in normative and pathological conditions of aging. Six institutions within the Consortium contribute Primary Mentors (Preceptors) and Affiliate Faculty to this Training Program, including: The University of Arizona, Arizona State University, Barrow Neurological Institute, Banner Sun Health Research Institute, The Translational Genomics Research Institute, and Banner Alzheimer's Institute. Faculty have complementary strengths in brain imaging, computer science, genomics, molecular biology, basic systems, behavioral and cognitive neuroscience, experimental therapeutics, computational and statistical analyses of complex datasets and clinical neuropathological approaches. The research is aimed at promoting the scientific understanding of the aging brain, early detection of AD and ADRD and developing effective treatment and prevention therapies. Fellows benefit from a 4 person Professional Development Committee (PDC) whose purpose is to provide guidance on the creation of a collaborative experimental training plan that fosters opportunities to work, learn and produce across institutions. The primary research Mentor, in whose laboratory the Fellow is based, is chosen from the Preceptor list, as is the secondary research Mentor, but they can be from any institution amongst the consortium. The secondary Mentor plays an active role in the research undertaken by the Fellow, which goes beyond making facilities available. A tertiary Mentor is selected on the basis of experimental or pedagogical expertise, and a fourth member of the PDC is chosen from amongst the 6-person leadership team to provide an additional level of oversight. Exposure to the unique Arizona tradition of cooperation and collaboration that knows no institutional boundaries has significantly enriched the skill sets and professional development of our Fellows during the training period. In addition to multi-laboratory research exposure, another unique programmatic aspect takes the form of three workshops per year, varying from 1-3 days, in which all Fellows participate. These include statewide events that Training Faculty attend (Annual Arizona Alzheimer's Consortium Retreat), or that faculty, graduate students and postdocs attend (Alzheimer's Consortium Annual Scientific Conference), as well as broader participation in national and international professional events (e.g., Society for Neuroscience meeting). Our goal to give the Fellow the freedom to draw broadly from facilities and expertise across the Consortium has exposed our Trainees to the power of collaborative, interdisciplinary interactions that can facilitate development of strong experimental designs to test important questions, providing the foundation for productive future work.

项目概要/摘要 题为“衰老与阿尔茨海默病的神经生物学”的博士后培训资助已提交 通过亚利桑那大学代表亚利桑那州阿尔茨海默病联盟。培训师资选择 该联盟由高度互动的研究人员组成，其科学兴趣包括衰老、 阿尔茨海默病 (AD) 和 AD 相关痴呆 (ADRD) 涵盖苍蝇、啮齿动物和非人灵长类动物 衰老模型，以及衰老正常和病理条件下的人类研究。六大机构 在联盟内为该培训计划贡献主要导师（导师）和附属教师， 包括：亚利桑那大学、亚利桑那州立大学、巴罗神经研究所、Banner Sun 健康研究所、转化基因组学研究所和班纳阿尔茨海默氏症研究所。 教师在脑成像、计算机科学、基因组学、分子生物学、基础科学等方面具有互补的优势。 系统、行为和认知神经科学、实验疗法、计算和统计 复杂数据集和临床神经病理学方法的分析。该研究旨在促进 对大脑老化的科学认识，及早发现 AD 和 ADRD 并开发有效的 治疗和预防疗法。研究员受益于 4 人专业发展委员会 （PDC），其目的是为制定协作实验培训计划提供指导， 促进跨机构工作、学习和生产的机会。主要研究导师，其 研究员所在的实验室是从导师名单中选出的，二级研究导师也是如此，但他们 可以来自联盟中的任何机构。二级导师在其中发挥着积极作用 该研究员进行的研究不仅仅是提供设施。三级导师是 根据实验或教学专业知识选出，并选出 PDC 的第四名成员 从 6 人领导团队中选出，以提供额外级别的监督。接触独特的 亚利桑那州不分制度界限的合作与协作传统已显着 丰富了我们的研究员在培训期间的技能和专业发展。此外 多实验室研究接触，另一个独特的计划方面采取三个研讨会的形式 每年一次，为期 1-3 天，所有研究员都参加。其中包括培训的全州范围内的活动 教职人员参加（年度亚利桑那州阿尔茨海默病协会静修会），或者教职人员、研究生和 博士后参加（阿尔茨海默氏病联盟年度科学会议），以及更广泛的参与 国家和国际专业活动（例如神经科学学会会议）。我们的目标是给予 伙伴们可以自由地从整个联盟的设施和专业知识中广泛汲取经验，这暴露了我们的 学员将了解协作、跨学科互动的力量，从而促进强大的发展 实验设计来测试重要问题，为未来富有成效的工作奠定基础。