Postdoctoral Training, Neurobiology of Aging and Alzheimer's Disease

博士后培训，衰老和阿尔茨海默病的神经生物学

• 批准号: 10419557
• 负责人: CAROL A. BARNES
• 金额: $ 22.92万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10419557
• 关键词: Aging; Alzheimer' s Disease; Neurobiology; post-doctoral training

Project Summary/Abstract The postdoctoral training grant entitled “The Neurobiology of Aging and Alzheimer's Disease” is submitted through the University of Arizona on behalf of the Arizona Alzheimer's Consortium. The training faculty chosen from the Consortium consist of highly interactive investigators whose scientific interests include aging, Alzheimer's disease (AD) and AD-related dementias (ADRD) and spans fly, rodent, and nonhuman primate models of aging, as well as human studies in normative and pathological conditions of aging. Six institutions within the Consortium contribute Primary Mentors (Preceptors) and Affiliate Faculty to this Training Program, including: The University of Arizona, Arizona State University, Barrow Neurological Institute, Banner Sun Health Research Institute, The Translational Genomics Research Institute, and Banner Alzheimer's Institute. Faculty have complementary strengths in brain imaging, computer science, genomics, molecular biology, basic systems, behavioral and cognitive neuroscience, experimental therapeutics, computational and statistical analyses of complex datasets and clinical neuropathological approaches. The research is aimed at promoting the scientific understanding of the aging brain, early detection of AD and ADRD and developing effective treatment and prevention therapies. Fellows benefit from a 4 person Professional Development Committee (PDC) whose purpose is to provide guidance on the creation of a collaborative experimental training plan that fosters opportunities to work, learn and produce across institutions. The primary research Mentor, in whose laboratory the Fellow is based, is chosen from the Preceptor list, as is the secondary research Mentor, but they can be from any institution amongst the consortium. The secondary Mentor plays an active role in the research undertaken by the Fellow, which goes beyond making facilities available. A tertiary Mentor is selected on the basis of experimental or pedagogical expertise, and a fourth member of the PDC is chosen from amongst the 6-person leadership team to provide an additional level of oversight. Exposure to the unique Arizona tradition of cooperation and collaboration that knows no institutional boundaries has significantly enriched the skill sets and professional development of our Fellows during the training period. In addition to multi-laboratory research exposure, another unique programmatic aspect takes the form of three workshops per year, varying from 1-3 days, in which all Fellows participate. These include statewide events that Training Faculty attend (Annual Arizona Alzheimer's Consortium Retreat), or that faculty, graduate students and postdocs attend (Alzheimer's Consortium Annual Scientific Conference), as well as broader participation in national and international professional events (e.g., Society for Neuroscience meeting). Our goal to give the Fellow the freedom to draw broadly from facilities and expertise across the Consortium has exposed our Trainees to the power of collaborative, interdisciplinary interactions that can facilitate development of strong experimental designs to test important questions, providing the foundation for productive future work.

项目摘要/摘要 博士后培训助学金《衰老与阿尔茨海默病的神经生物学》提交 通过亚利桑那大学代表亚利桑那州阿尔茨海默氏症联盟。选定的培训教员 该联盟由高度互动的研究人员组成，他们的科学兴趣包括衰老， 阿尔茨海默病(AD)和AD相关痴呆(ADRD)以及跨越苍蝇、啮齿动物和非人类灵长类动物 衰老模型，以及在正常和病理条件下衰老的人体研究。六所院校 在为本培训计划贡献主要导师(P接受者)和附属学院的联盟内， 包括：亚利桑那大学、亚利桑那州立大学、巴罗神经学研究所、Banner Sun 健康研究所、翻译基因组研究所和班纳阿尔茨海默氏症研究所。 教师在脑成像、计算机科学、基因组学、分子生物学、基础 系统、行为和认知神经科学、实验治疗学、计算和统计学 复杂数据集的分析和临床神经病理学方法。这项研究旨在促进 科学认识脑老化，及早发现AD和ADRD并制定有效措施 治疗和预防疗法。研究员受益于4人专业发展委员会 (PDC)，其目的是为创建协作实验培训计划提供指导 促进各机构之间的工作、学习和生产机会。主要研究导师，在他的 研究员所在的实验室是从P受体列表中选择的，第二研究导师也是如此，但他们 可以来自财团中的任何机构。二级导师在培训中发挥着积极作用 由研究员进行的研究，这不仅仅是提供设施。三级导师是 根据实验或教学专业知识挑选，并选出PDC的第四名成员 从6人领导团队中提供额外的监督级别。接触独一无二的 亚利桑那州没有制度界限的合作和协作的传统意义重大 在培训期间丰富了我们研究员的技能和专业发展。除了……之外 多实验室研究曝光，另一个独特的方案方面采取三个研讨会的形式 每年，从1-3天不等，所有研究员都参加。这些活动包括全州范围的活动，培训 教职员工参加(亚利桑那州阿尔茨海默氏症联盟年度务虚会)，或者教职员工、研究生和 博士后参加(阿尔茨海默病协会年度科学会议)，以及更广泛地参与 国家和国际专业活动(例如，神经科学学会会议)。我们的目标是给 研究员广泛利用整个财团的设施和专业知识的自由暴露了我们的 学员将获得协作、跨学科互动的力量，以促进强大的 测试重要问题的实验设计，为富有成效的未来工作提供基础。