Administrative Core (AC) Core A

摘要/摘要：行政核心A 行政核心(AC)将领导和协调所有核心和项目的运作，以确保成功 在实现精准老龄网络(PAN)的战略目标方面。潘的目标是使 制定个性化的干预措施，以维持健康、福祉，并优化认知功能 增进健康，预防或减轻阿尔茨海默病(AD)和AD相关痴呆的负担 (ADRD)。 AC将由卡罗尔·巴恩斯和梅雷迪思·海领导，他们总共拥有数十年的财富 具有领导大型、复杂项目的行政经验。他们将得到PAN执行人员的协助 委员会和指导委员会，并由外部咨询委员会在确定优先事项方面提供咨询 对于中心活动和资源，促进最佳互动，解决潜在的利益冲突， 审查和更新研究界，并实施正在进行的评估计划 生产力和影响力的适当指标和标记。 AC的主要职能还包括确保稳健的数据和生物谱共享计划、会议 协调和后续行动、旅行安排、财政拨款和报告、遵守联邦和 机构赠款管理和报告要求、收集、核对和确认评价 指标。将通过制定一项多年期评价计划来评估总体进展情况 具体的里程碑，以确定需要改进的领域并发起更改。该计划将具体地 旨在评估(A)PAN的整体业绩，包括空调的有效性，以及(B) 核心和项目的生产率、有效性、利用率和机会，以及(C)积极参与 外部顾问对PAN领导层的评价。最后，AC将加强和扩大稳健， 通过促进相互富有成效的互动，开展有效的沟通、传播和外联活动 在卫生专业、科学和公民社区的成员中。 在外部咨询委员会和国家臭氧机构方案领导的投入下，项目领导、共同-- 领导、副调查人员和关键人员，审计委员会将确保PAN提供广泛的数据， 生物多样性和资源共享计划，促进独特资源的快速和深远利用 (生物样品、原始和处理数据、算法和分析方法)由PAN创建。他们还将 扩大与NIA资助的其他阿尔茨海默病中心领导层和关键人员的互动 位于四个PAN临床站点以及全国各地。此外，AC将管理 与旨在研究衰老、AD和/或ADRD的现有纵向队列的相互作用。

SUMMARY/ABSTRACT: Administrative Core A The Administrative Core (AC) will lead and coordinate operations of all Cores and Projects to assure success in achieving the strategic goals of the Precision Aging Network (PAN). PAN’s goals are to enable the development of individualized interventions to maintain health, well-being, and function to optimize cognitive healthspan and to prevent or reduce the burden of Alzheimer’s disease (AD) and AD-related dementias (ADRD). The AC will be led by Carol Barnes and Meredith Hay who have a combined several decades worth of administrative experience in directing large, complex projects. They will be assisted by the PAN Executive Committee and Steering Committee and advised by the External Advisory Committee in establishing priorities for center activities and resources, promoting optimal interactions, resolving potential conflicts of interest, reviewing and updating the research community, and implementing an ongoing evaluation plan with appropriate metrics and markers of productivity and impact. Key functions of the AC also include ensuring a robust data and biospecimen sharing plan, meeting coordination and follow-up, travel arrangements, financial allocations and reports, compliance with federal and institutional grants management and reporting requirements, collection, collation and confirmation of evaluation metrics. Overall progress will be assessed through the development of a multi-year Evaluation Plan with specific milestones to identify areas for improvement and initiate changes. The plan will be specifically designed to assess the (a) overall performance of PAN, including the effectiveness of the AC, and (b) productivity, effectiveness, utilization and opportunities of the Cores and Projects, and also (c) actively engage the external advisors in evaluation of the PAN leadership. Lastly, the AC will strengthen and expand robust, effective communication, dissemination and outreach activities by fostering mutually productive interactions among members of health professional, scientific and citizen communities. With input from the External Advisory Committee and NIA programmatic leadership, the Project Leads, co- Leads, Associate Investigators, and key personnel, the AC will ensure that PAN provides a broad-based data, biospecimen and resource sharing plan to facilitate the rapid and far-reaching use of the unique resources (biospecimens, raw and processed data, algorithms, and analytical methods) created by PAN. They will also expand interactions with the leadership and key personnel of other NIA-funded Alzheimer’s Disease Centers located at the four PAN clinical sites as well as across the country. Additionally, the AC will manage interactions with existing longitudinal cohorts designed to investigate aging, AD, and/or ADRD.