Core 001 - Virology Core

核心 001 - 病毒学核心

• 批准号: 10428298
• 负责人: Mansun Law
• 金额: $ 35.42万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10428298
• 关键词: Animals; Antibodies; Antibody Response; Antibody Specificity; Antibody titer measurement; Antigens; B-Lymphocytes; Biological Assay; Blood specimen; Cell Survival; Collection; Complex; Cost efficiency; Data; Databases; Ensure; Enzyme-Linked Immunosorbent Assay; Foundations; Freezing; Glycoproteins; Goals; Hepatitis C Antibodies; Hepatitis C Vaccine; Hepatitis C virus; Human; Immunize; Immunology procedure; International; Laws; Lead; Libraries; Liquid substance; Macaca; Methods; Monitor; Mus; Nitrogen; Peer Review; Peripheral Blood Mononuclear Cell; Plasma; Plasmablast; Primates; Procedures; Process; Program Research Project Grants; Protocols documentation; Publications; Quality Control; Reagent; Recombinants; Reproducibility; Reproducibility of Results; Research; Research Personnel; Research Project Grants; Resources; Running; Sampling; Ships; Standardization; Structure; System; Time; Vaccine Antigen; Vaccine Research; Virus; Western Blotting; Work; data quality; design; experimental study; improved; member; mutant; neutralizing antibody; programs; response; synergism; vaccine development; vaccine trial; virology

PROJECT SUMMARY Core B Virology will serve as a centralized research resources to facilitate the research objectives of this P01 program. The functions of Core B include (1) collect and develop a library of HCV research reagents and maintain their supply for the program; (2) perform standardized assays for quality-control of HCV antigens, measurement of antibody titers and virus neutralizing activities, to ensure consistent and reproducibility of experimental results; (3) processing animal samples for downstream experiments; (4) develop and document standardized research reagents and assays to accelerate HCV vaccine development. Core B Virology will improve cost efficiency, data quality and synergy of the research projects and cores of the P01 program.

项目摘要 核心B病毒学将作为集中研究资源，以促进本P01的研究目标 程序.核心B的功能包括：（1）收集和开发HCV研究试剂库， 维持其对该计划的供应;（2）进行HCV抗原质量控制的标准化测定， 抗体滴度和病毒中和活性的测量，以确保 实验结果;（3）处理动物样品用于下游实验;（4）开发和记录 标准化的研究试剂和检测方法，以加速HCV疫苗的开发。核心B病毒学将 提高成本效益，数据质量和研究项目的协同作用和P01计划的核心。