Core 001 - Virology Core
Core 001 - Virology Core
批准号:
10428298
负责人:
Mansun Law
金额:
$35.42万
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
未结题
起止时间:
2022-02-01 至 2027-01-31
关键词:
AnimalsAntibodiesAntibody ResponseAntibody SpecificityAntibody titer measurementAntigensB-LymphocytesBiological AssayBlood specimenCell SurvivalCollectionComplexCost efficiencyDataDatabasesEnsureEnzyme-Linked Immunosorbent AssayFoundationsFreezingGlycoproteinsGoalsHepatitis C AntibodiesHepatitis C VaccineHepatitis C virusHumanImmunizeImmunology procedureInternationalLawsLeadLibrariesLiquid substanceMacacaMethodsMonitorMusNitrogenPeer ReviewPeripheral Blood Mononuclear CellPlasmaPlasmablastPrimatesProceduresProcessProgram Research Project GrantsProtocols documentationPublicationsQuality ControlReagentRecombinantsReproducibilityReproducibility of ResultsResearchResearch PersonnelResearch Project GrantsResourcesRunningSamplingShipsStandardizationStructureSystemTimeVaccine AntigenVaccine ResearchVirusWestern BlottingWorkdata qualitydesignexperimental studyimprovedmembermutantneutralizing antibodyprogramsresponsesynergismvaccine developmentvaccine trialvirology
中文摘要
项目摘要
核心B病毒学将作为集中研究资源,以促进本P01的研究目标
程序.核心B的功能包括:(1)收集和开发HCV研究试剂库,
维持其对该计划的供应;(2)进行HCV抗原质量控制的标准化测定,
抗体滴度和病毒中和活性的测量,以确保
实验结果;(3)处理动物样品用于下游实验;(4)开发和记录
标准化的研究试剂和检测方法,以加速HCV疫苗的开发。核心B病毒学将
提高成本效益,数据质量和研究项目的协同作用和P01计划的核心。
英文摘要
PROJECT SUMMARY
Core B Virology will serve as a centralized research resources to facilitate the research objectives of this P01
program. The functions of Core B include (1) collect and develop a library of HCV research reagents and
maintain their supply for the program; (2) perform standardized assays for quality-control of HCV antigens,
measurement of antibody titers and virus neutralizing activities, to ensure consistent and reproducibility of
experimental results; (3) processing animal samples for downstream experiments; (4) develop and document
standardized research reagents and assays to accelerate HCV vaccine development. Core B Virology will
improve cost efficiency, data quality and synergy of the research projects and cores of the P01 program.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Understanding human antibody responses to chronic viral hepatitis C
-
批准号:10551237
-
项目类别:
-
资助金额:$62.18万
-
财政年份:2022
-
负责人:Mansun Law
-
依托单位:
Broadly Effective HCV Vaccine
-
批准号:10557871
-
项目类别:
-
资助金额:$208.35万
-
财政年份:2022
-
负责人:Mansun Law
-
依托单位:
Admin Core
-
批准号:10557872
-
项目类别:
-
资助金额:$11.66万
-
财政年份:2022
-
负责人:Mansun Law
-
依托单位:
Admin Core
-
批准号:10428297
-
项目类别:
-
资助金额:$8.61万
-
财政年份:2022
-
负责人:Mansun Law
-
依托单位:
Broadly Effective HCV Vaccine
-
批准号:10428296
-
项目类别:
-
资助金额:$210.29万
-
财政年份:2022
-
负责人:Mansun Law
-
依托单位:
Understanding human antibody responses to chronic viral hepatitis C
-
批准号:10435356
-
项目类别:
-
资助金额:$62.18万
-
财政年份:2022
-
负责人:Mansun Law
-
依托单位:
Core 001 - Virology Core
-
批准号:10557873
-
项目类别:
-
资助金额:$34.73万
-
财政年份:2022
-
负责人:Mansun Law
-
依托单位:
Rheumatoid factor and cryoglobulinemia in chronic viral infection
-
批准号:9896553
-
项目类别:
-
资助金额:$29.03万
-
财政年份:2019
-
负责人:Mansun Law
-
依托单位:
Cooperative Center for the study of HCV antibody responses and vaccine antigens
-
批准号:9248879
-
项目类别:
-
资助金额:$91.87万
-
财政年份:2016
-
负责人:Mansun Law
-
依托单位:
Administrative Core
-
批准号:9096639
-
项目类别:
-
资助金额:$27.86万
-
财政年份:2016
-
负责人:Mansun Law
-
依托单位:
Structure and function of Hepacivirus envelope glycoprotein
-
批准号:9084122
-
项目类别:
-
资助金额:$62.56万
-
财政年份:2016
-
负责人:Mansun Law
-
依托单位:
Cooperative Center for the study of HCV antibody responses and vaccine antigens
-
批准号:9903195
-
项目类别:
-
资助金额:$88.83万
-
财政年份:2016
-
负责人:Mansun Law
-
依托单位:
Antibody responses to HCV vaccine antigens in infection and vaccination
-
批准号:9096640
-
项目类别:
-
资助金额:$39.0万
-
财政年份:2016
-
负责人:Mansun Law
-
依托单位:
Dissecting virus neutralizing determinants to guide HCV vaccine development
-
批准号:9212766
-
项目类别:
-
资助金额:$45.71万
-
财政年份:2014
-
负责人:Mansun Law
-
依托单位:
Dissecting virus neutralizing determinants to guide HCV vaccine development
-
批准号:9017908
-
项目类别:
-
资助金额:$45.0万
-
财政年份:2014
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负责人:Mansun Law
-
依托单位:
Dissecting virus neutralizing determinants to guide HCV vaccine development
-
批准号:8728397
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项目类别:
-
资助金额:$79.27万
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财政年份:2013
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负责人:Mansun Law
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依托单位:
Hepatitis C virus E2 glycoprotein
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批准号:7570115
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项目类别:
-
资助金额:$28.49万
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财政年份:2009
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负责人:Mansun Law
-
依托单位:
Hepatitis C virus E2 glycoprotein
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批准号:7847617
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项目类别:
-
资助金额:$23.74万
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财政年份:2009
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负责人:Mansun Law
-
依托单位:
Discovery of potent human antibodies for prevention of (recurrent) HCV infection
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批准号:7904000
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项目类别:
-
资助金额:$46.9万
-
财政年份:2008
-
负责人:Mansun Law
-
依托单位:
Understanding human neutralizing antibodies to hepatitis C virus
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批准号:8663827
-
项目类别:
-
资助金额:$54.84万
-
财政年份:2008
-
负责人:Mansun Law
-
依托单位:
海外基金