Rheumatoid factor and cryoglobulinemia in chronic viral infection

慢性病毒感染中的类风湿因子和冷球蛋白血症

基本信息

  • 批准号:
    9896553
  • 负责人:
  • 金额:
    $ 29.03万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-12-18 至 2021-11-30
  • 项目状态:
    已结题

项目摘要

Rheumatoid factor and cryoglobulinemia in chronic viral infection Mixed cryoglobulinemia (MC) is strongly associated with chronic HCV infection. MC is an immune complex-mediated medical condition and is found in 40-60% of chronic HCV patients, with 5-15% patients develop clinical symptoms ranging from purpura, arthralgia, skin ulcers, peripheral neuropathy, glomerulonephritis and myocarditis. HCV-related MC greatly affects patients’ quality of life therefore a priority for HCV treatment. The pathogenic mechanism of MC is poorly understood, although it is suggested that HCV infection can stimulate unregulated B cell proliferation, and in some cases, the production of anti-antibody, i.e. rheumatoid factor (RF), of the IgM isotype. The HCV-induced RF in turn forms immune complexes with anti-HCV antibodies and HCV antigens that are sensitive to precipitation at temperature below 37oC which are known as cryoglobulins. However, recent studies reported that successful HCV treatment can improve symptoms of MC but cryoglobulins may still persist, indicating other non-viral antigens may be involved in the formation of cryoglobulins. In Aim 1 of this proposed study, we will identify the antigens present in cryoglobulins by a proteomic approach, both before and after successful HCV treatment, in order to decipher the composition and diversity of cryoglobulins and the mechanism of their formation. In Aim 2, we will study RF from MC patients in order to understand the diversity of antibody gene usage and their target epitopes, and whether HCV clearance may restore RF to normal level. Our goal is to develop novel experimental systems and reagents in this exploratory/developmental project that will be useful for understanding the disease mechanism of MC, and for defining the molecular properties of RF in different microbial infections and autoimmune conditions in the long term.
慢性病毒感染中的类风湿因子和冷球蛋白血症

项目成果

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Mansun Law其他文献

Mansun Law的其他文献

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{{ truncateString('Mansun Law', 18)}}的其他基金

Understanding human antibody responses to chronic viral hepatitis C
了解人类抗体对慢性丙型病毒性肝炎的反应
  • 批准号:
    10551237
  • 财政年份:
    2022
  • 资助金额:
    $ 29.03万
  • 项目类别:
Broadly Effective HCV Vaccine
广泛有效的 HCV 疫苗
  • 批准号:
    10557871
  • 财政年份:
    2022
  • 资助金额:
    $ 29.03万
  • 项目类别:
Admin Core
管理核心
  • 批准号:
    10557872
  • 财政年份:
    2022
  • 资助金额:
    $ 29.03万
  • 项目类别:
Admin Core
管理核心
  • 批准号:
    10428297
  • 财政年份:
    2022
  • 资助金额:
    $ 29.03万
  • 项目类别:
Broadly Effective HCV Vaccine
广泛有效的 HCV 疫苗
  • 批准号:
    10428296
  • 财政年份:
    2022
  • 资助金额:
    $ 29.03万
  • 项目类别:
Core 001 - Virology Core
核心 001 - 病毒学核心
  • 批准号:
    10557873
  • 财政年份:
    2022
  • 资助金额:
    $ 29.03万
  • 项目类别:
Core 001 - Virology Core
核心 001 - 病毒学核心
  • 批准号:
    10428298
  • 财政年份:
    2022
  • 资助金额:
    $ 29.03万
  • 项目类别:
Understanding human antibody responses to chronic viral hepatitis C
了解人类抗体对慢性丙型病毒性肝炎的反应
  • 批准号:
    10435356
  • 财政年份:
    2022
  • 资助金额:
    $ 29.03万
  • 项目类别:
Cooperative Center for the study of HCV antibody responses and vaccine antigens
HCV抗体反应和疫苗抗原研究合作中心
  • 批准号:
    9248879
  • 财政年份:
    2016
  • 资助金额:
    $ 29.03万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    9096639
  • 财政年份:
    2016
  • 资助金额:
    $ 29.03万
  • 项目类别:

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